Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Rat AK1 Protein

Cat.No. : AK1-582R
Product Overview : Recombinant Rat AK1 full length or partial length protein was expressed.
  • Specification
  • Gene Information
  • Related Products
Source : Mammalian Cells
Species : Rat
Tag : His
Form : Liquid or lyophilized powder
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method.
Purity : >80%
Notes : This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
Storage : Store it at +4 ºC for short term. For long term storage, store it at -20 ºC~-80 ºC.
Storage Buffer : PBS buffer
Gene Name : Ak1 adenylate kinase 1 [ Rattus norvegicus ]
Official Symbol : AK1
Gene ID : 24183
mRNA Refseq : NM_024349.2
Protein Refseq : NP_077325.2
MIM :
UniProt ID : P39069

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (25)

Ask a question
Is AK1 protein involved in any other cellular processes besides energy metabolism? 11/22/2022

Besides its role in energy metabolism, AK1 protein has also been implicated in cell cycle regulation, DNA damage repair, regulation of protein-protein interactions, and modulation of cellular signaling pathways.

Is there any clinical significance of AK1 protein outside of adenylate kinase deficiency? 10/31/2022

While adenylate kinase deficiency is the primary clinical consequence associated with AK1 protein mutations, altered AK1 expression or activity has been observed in some pathological conditions, including cancer, neurodegenerative disorders, and cardiovascular diseases.

Is AK1 protein specific to any particular tissue or organ? 10/28/2022

AK1 protein is ubiquitously expressed across different tissues and organs in the body.

Are there any disorders associated with mutations in AK1 protein? 03/28/2022

Yes, mutations in the AK1 gene can lead to a rare genetic disorder known as hemolytic anemia due to adenylate kinase deficiency. This condition is characterized by the destruction of red blood cells.

Can AK1 protein be targeted for therapeutic purposes? 01/08/2022

While specific therapeutic agents targeting AK1 protein are not currently available, there is ongoing research to explore its potential as a therapeutic target. Manipulating AK1 activity, expression, or regulation may hold promise for the treatment of certain diseases, particularly those where altered metabolism plays a role.

Where is AK1 protein primarily located in the cell? 11/30/2021

AK1 protein is predominantly found in the cytoplasm and the cytoskeleton of cells.

Are there any AK1 protein isoforms or splice variants? 06/22/2021

Yes, alternative splicing of the AK1 gene can give rise to different isoforms of AK1 protein. These isoforms might have variations in their enzymatic activity, subcellular localization, or interaction with other proteins. Further studies are needed to fully understand the functional significance of AK1 protein isoforms.

Are there any drugs that indirectly affect AK1 protein activity? 09/18/2020

Some drugs may indirectly affect AK1 protein activity by altering cellular metabolism or energy levels. Drugs that target cellular respiration or ATP production, such as certain chemotherapeutic agents or metabolic modulators, may have an impact on AK1 protein activity, although it may not be their primary target.

Does AK1 protein have any known interactions with other proteins? 09/04/2020

Yes, AK1 protein has been reported to interact with a variety of other proteins involved in cellular processes, including cytoskeletal proteins, enzymes involved in ATP synthesis, and proteins involved in cell signaling pathways.

What are the future directions of AK1 protein research? 06/24/2020

Future research on AK1 protein aims to elucidate its exact physiological roles in different tissues and organs. Additionally, understanding the underlying mechanisms of AK1-related disorders may lead to the development of targeted therapies.

Is AK1 protein involved in any neurological disorders? 03/25/2020

There is evidence to suggest that AK1 protein may play a role in neurodegenerative disorders. Studies have shown altered AK1 expression and activity in the brains of individuals with Alzheimer's disease and Parkinson's disease. However, the exact mechanisms and implications are still being investigated.

Are there any therapeutic implications of AK1 protein? 03/18/2020

Currently, there are no specific therapeutics targeting AK1 protein. However, further research on AK1 and its dysregulation may offer potential avenues for intervention in disorders related to adenylate metabolism.

Are there any animal models or cell lines used to study AK1 protein? 11/23/2019

Yes, animal models and cell lines are commonly used to study AK1 protein. Mouse models with AK1 gene knockout or overexpression have been generated to investigate its role in various physiological and pathological conditions. Additionally, cell lines derived from different tissues can be used to examine AK1 protein function and regulation in vitro.

Are there any known inhibitors or activators of AK1 protein? 06/10/2019

Some small-molecule inhibitors of AK1 protein have been developed for research purposes, but they are not currently used in clinical settings. There is limited information on activators of AK1 protein.

How is AK1 protein studied in the laboratory? 05/25/2019

AK1 protein is often studied through techniques such as protein purification, enzyme activity assays, gene knockout or overexpression experiments, immunofluorescence microscopy, and biochemical analyses to investigate its function, regulation, and potential therapeutic implications.

Can AK1 protein be used as a diagnostic marker? 03/18/2019

While AK1 protein is not commonly used as a diagnostic marker, its deficiency can be detected through genetic testing for the diagnosis of hemolytic anemia due to adenylate kinase deficiency.

Is there any role of AK1 protein in immune system function? 01/18/2019

While AK1 protein's role in immune system function is not well-characterized, some studies have suggested its involvement in T-cell activation and proliferation. However, further research is needed to clarify the specific mechanisms and implications in immune function.

Can AK1 protein have an impact on fertility or reproductive health? 12/31/2018

While there is limited research on AK1 protein's role in fertility and reproductive health, some studies have suggested its involvement in sperm motility and function. Further investigations are needed to fully understand the potential impact of AK1 protein on reproductive processes.

Can AK1 protein interact with other proteins? 04/25/2017

Yes, AK1 protein can interact with various other proteins to form protein complexes or participate in cellular pathways. For example, it has been reported to physically interact with certain chaperones, signaling molecules, and other enzymes involved in nucleotide metabolism. These interactions can regulate AK1 protein activity and influence its cellular functions.

Is there any research on the potential therapeutic targeting of AK1 protein? 02/05/2017

While there are currently no specific therapeutic agents targeting AK1 protein, some studies have explored its potential as a target in certain diseases, such as cancer. Manipulating AK1 activity or expression may have implications for the treatment of certain malignancies.

Can AK1 protein be used as a prognostic marker in any diseases? 11/21/2016

Currently, there is limited evidence to suggest using AK1 protein as a prognostic marker. However, further research is needed to explore its potential value as a prognostic indicator in specific diseases.

Are there any diseases associated with mutations in the AK1 gene? 08/05/2016

Yes, mutations in the AK1 gene have been linked to adenylate kinase deficiency, an autosomal recessive disorder characterized by hemolytic anemia and muscle weakness. It is a rare condition, and patients often present with symptoms such as fatigue, exercise intolerance, and elevated levels of certain molecules in the blood.

How is AK1 protein regulated in the cell? 07/23/2016

The activity of AK1 protein is regulated by various factors, including the concentrations of its substrates and products (AMP, ADP, and ATP), pH levels, and changes in cellular redox status.

How is AK1 protein linked to energy metabolism? 01/20/2016

AK1 protein plays a role in maintaining proper energy metabolism by regulating adenylate pools in the cell. It contributes to the production of ATP, the energy currency of the cell.

Is AK1 protein ubiquitously expressed in all tissues? 03/25/2015

AK1 protein is expressed in a wide range of tissues, but its expression levels can vary. It is highly expressed in tissues with high energy demands, such as skeletal muscle, heart, and brain. However, it is also found in other tissues, albeit at lower levels. This widespread expression reflects the importance of AK1 protein in nucleotide metabolism and energy homeostasis throughout the body.

Customer Reviews (4)

Write a review
Reviews
04/17/2021

    AK1 protein boasts an exemplary caliber, rendering it a remarkable choice that impeccably aligns with my experimental prerequisites.

    03/29/2019

      the manufacturer's commitment to excellence extends beyond the mere production of the AK1 protein.

      07/30/2018

        Their exceptional technical support team stands ready to tackle any obstacles or queries I may encounter during my experimental journey.

        02/17/2015

          Its exceptional quality and consistency instill confidence in attaining accurate and reproducible results

          Ask a Question for All AK1 Products

          Required fields are marked with *

          My Review for All AK1 Products

          Required fields are marked with *

          0

          Inquiry Basket

          cartIcon
          logo

          FOLLOW US

          Terms and Conditions        Privacy Policy

          Copyright © 2024 Creative BioMart. All Rights Reserved.

          Contact Us

          • /

          Stay Updated on the Latest Bioscience Trends