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Recombinant Rat Apoa5 protein, His-tagged

Cat.No. : Apoa5-2089R
Product Overview : Recombinant Rat Apoa5 aa. (Gln169~Gly367 (Accession # Q9QUH3)) fused with N-terminal His tag was produced in E. coli cells.
  • Specification
  • Gene Information
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Source : E. coli
Species : Rat
Tag : His
Form : Freeze-dried powder
Molecular Mass : 27kDa as determined by SDS-PAGE reducing conditions.
Protein length : Gln169~Gly367 (Accession # Q9QUH3)
Endotoxin : <1.0EU per 1ug (determined by the LAL method)
Purity : >95%
Characteristic : The isoelectric point is 6.2.
Applications : SDS-PAGE; WB; ELISA; IP.
Stability : The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Storage Buffer : Supplied as lyophilized form in 20mM Tris, 500mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5% trehalose, and preservative.
Reconstitution : Reconstitute in ddH2O.
Gene Name : Apoa5 apolipoprotein A5 [ Rattus norvegicus (Norway rat) ]
Official Symbol : Apoa5
Synonyms : KIR2DL3; killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3; p58; NKAT; GL183; NKAT2; CD158b; NKAT2A; killer cell immunoglobulin-like receptor 2DL3; NKAT2B; CD158B2; KIR-K7b; KIR-K7c; KIR2DS5; KIRCL23; KIR-023GB; CD158 antigen-like family member B2; NKAT-2; killer cell immunoglobulin-like receptor two domains long cytoplasmic tail 3; killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5; killer inhibitory receptor cl 2-3; natural killer associated transcript 2; natural killer cell inhibitory receptor KIR2DL3; p58 NK receptor CL-6; p58 natural killer cell receptor clone CL-6; p58.2 MHC class-I specific NK receptor
Gene ID : 140638
mRNA Refseq : NM_001277264.1
Protein Refseq : NP_001264193.1
UniProt ID : Q9QUH3

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (28)

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Is APOA5 protein involved in any other physiological processes apart from lipid metabolism? 10/20/2022

While the primary role of APOA5 protein is in lipid metabolism, emerging research suggests its involvement in other physiological processes. It has been implicated in inflammation, insulin sensitivity, and energy metabolism, although the mechanisms and extent of these associations are still being explored.

How does APOA5 protein interact with other lipoproteins in the body? 05/11/2022

APOA5 protein primarily interacts with chylomicrons and very-low-density lipoproteins (VLDL) in the bloodstream. It helps in the formation and clearance of these lipoproteins, which transport lipids, including triglycerides, throughout the body.

Is there a link between APOA5 protein and obesity? 02/15/2022

Yes, APOA5 protein has been linked to obesity. Certain APOA5 gene variants have been associated with higher triglyceride levels and an increased risk of obesity.

How is APOA5 protein linked to cardiovascular health? 11/17/2021

APOA5 protein plays a crucial role in the regulation of triglyceride levels, which are an important risk factor for cardiovascular disease. Variants in the APOA5 gene that lead to lower APOA5 protein levels or function have been associated with increased triglyceride levels and an increased risk of cardiovascular disease.

What are the ongoing research areas in APOA5 protein studies? 11/13/2021

Ongoing research in APOA5 protein studies is focused on understanding the exact mechanisms by which APOA5 influences lipid metabolism, exploring the associations between APOA5 gene variants and various diseases, and investigating potential therapeutic strategies targeting APOA5 for the management of lipid-related disorders.

Is there a recommended diet or lifestyle changes for individuals with APOA5 gene variations? 08/01/2021

For individuals with APOA5 gene variations associated with increased triglyceride levels, a healthy lifestyle is generally recommended. This includes adopting a balanced diet that is low in saturated fat and high in fruits, vegetables, whole grains, and lean protein. Regular physical activity, weight management, and avoiding excessive alcohol consumption are also important factors in managing triglyceride levels.

Are there any ongoing clinical trials or therapeutic interventions targeting APOA5? 07/27/2021

Ongoing clinical trials and therapeutic interventions targeting APOA5 are limited, but several studies are exploring potential approaches. Some studies are investigating the use of gene therapy or gene editing techniques to modify APOA5 expression or function. Additionally, there are trials exploring the effects of drugs targeting other aspects of lipid metabolism, which may indirectly impact APOA5.

Can APOA5 gene variations affect cholesterol levels in addition to triglyceride levels? 11/05/2020

APOA5 gene variations primarily affect triglyceride levels, but they can also have some impact on cholesterol metabolism. Certain APOA5 variants have been associated with alterations in LDL cholesterol (bad cholesterol) and HDL cholesterol (good cholesterol) levels. However, the effects on cholesterol are generally less pronounced compared to their effects on triglycerides.

How prevalent are APOA5 gene variations in the general population? 11/04/2020

The prevalence of APOA5 gene variations varies across different populations. Some variants, such as the minor allele of rs662799, are relatively common, while others may be less prevalent. The exact frequency of APOA5 gene variations in the general population depends on various factors, including genetic ancestry and geographic location.

Are there any known therapeutic interventions targeting APOA5 protein? 07/28/2020

Currently, there are no specific therapeutic interventions targeting APOA5 protein available for clinical use. However, ongoing research is exploring the potential of modulating APOA5 levels or function as a therapeutic strategy for treating lipid-related disorders.

Can APOA5 protein levels be measured in clinical settings? 05/28/2020

Yes, APOA5 protein levels can be measured in clinical settings using specific laboratory techniques. These measurements are often used in research studies to understand the role of APOA5 protein in lipid metabolism and its association with various diseases.

Are there any known genetic or environmental factors that can amplify the effect of APOA5 gene variations? 05/06/2020

Studies have reported interactions between genetic variations in the APOA5 gene and factors like obesity, insulin resistance, and alcohol consumption, which can amplify the effect of APOA5 gene variations on triglyceride levels and the risk of cardiovascular diseases.

Is there any evidence to suggest that modifying APOA5 expression or function can lead to new therapeutic strategies for cardiovascular diseases? 04/17/2020

The modulation of APOA5 expression or function holds promise as a potential therapeutic strategy for cardiovascular diseases. Preclinical studies and limited clinical trials have shown that manipulating APOA5 levels or activity can have beneficial effects on lipid profiles and atherosclerosis development. However, further research is needed to fully establish the safety and efficacy of such interventions before they can be widely implemented.

Are there any known side effects or risks associated with modulating APOA5 expression or function? 04/06/2020

Modulating APOA5 expression or function is still a developing area of research, and the potential side effects or risks are not yet fully understood. Gene therapy or gene editing approaches could have off-target effects or unintended consequences. Therefore, further research and careful considerations are needed to ensure the safety and efficacy of such interventions.

Are there any known genetic variants or mutations in the APOA5 gene? 10/30/2019

Yes, there are known genetic variants in the APOA5 gene. Some of these variants, such as the T-1131C and C56G variants, have been associated with alterations in APOA5 protein levels and triglyceride metabolism.

Are there any lifestyle or dietary interventions specifically recommended for individuals with APOA5 gene variations and high triglyceride levels? 10/28/2019

For individuals with APOA5 gene variations and high triglyceride levels, lifestyle and dietary interventions are generally recommended. This may include following a low-fat, low-sugar diet, reducing alcohol consumption, engaging in regular physical activity, maintaining a healthy weight, and managing other risk factors such as hypertension and diabetes. However, it is essential to consult with a healthcare professional for personalized advice tailored to an individual's specific situation.

Can genetic testing be done to detect variations in the APOA5 gene? 10/26/2019

Yes, genetic testing can be done to detect variations in the APOA5 gene. Various methods, such as DNA sequencing or genotyping, can identify specific variations or mutations in the gene. This information can help assess an individual's risk for certain lipid disorders and cardiovascular diseases.

Can variations in the APOA5 gene influence the risk of pancreatitis? 10/17/2019

Yes, certain genetic variants in the APOA5 gene have been associated with an increased risk of pancreatitis, a condition characterized by inflammation of the pancreas. Elevated triglyceride levels, influenced by APOA5 variants, may contribute to the development of pancreatitis.

What are the implications of APOA5 protein research for personalized medicine? 10/16/2019

APOA5 protein research provides insights into the genetic and molecular factors contributing to lipid metabolism and cardiovascular diseases. Understanding an individual's APOA5 gene variants and their impact on triglyceride regulation may contribute to personalized treatment plans, risk assessment, and preventive strategies tailored to an individual's genetic profile.

Can lifestyle factors influence the expression or function of APOA5 protein? 05/07/2019

Yes, lifestyle factors such as diet and exercise can influence the expression and function of APOA5 protein. Certain dietary components, like omega-3 fatty acids, have been shown to upregulate APOA5 expression, while a high-fat diet or sedentary lifestyle may downregulate it.

Can variations in the APOA5 gene affect other lipid parameters besides triglycerides? 10/08/2018

Yes, variations in the APOA5 gene can influence other lipid parameters. Some studies have shown associations between APOA5 gene variants and levels of high-density lipoprotein (HDL) cholesterol and low-density lipoprotein (LDL) cholesterol, although the relationships are not as strong as those with triglycerides.

Can APOA5 gene variations be inherited from parents? 09/21/2018

Yes, APOA5 gene variations can be inherited from parents. They can be passed down through family generations, contributing to a higher risk of developing certain lipid disorders or cardiovascular diseases. However, it is important to note that genetic variations alone do not determine disease risk and can interact with other genetic and environmental factors.

Are there any known interactions between medications and APOA5 protein? 04/20/2018

Some studies suggest that certain medications, such as statins (cholesterol-lowering drugs) and fibrates (used to treat high triglyceride levels), may affect APOA5 protein levels. However, more research is needed to fully understand these interactions and their implications.

Can variations in the APOA5 gene impact response to lipid-lowering therapies? 12/04/2017

Yes, variations in the APOA5 gene can influence an individual's response to lipid-lowering therapies. Some studies have shown that certain APOA5 gene variants may affect the efficacy of medications like fibrates in reducing triglyceride levels.

Is there ongoing research into the role of APOA5 in other diseases or disorders? 10/11/2017

While the primary focus of APOA5 research has been on its involvement in lipid metabolism and cardiovascular diseases, there is also ongoing research into its potential role in other diseases and disorders. This includes conditions such as obesity, diabetes, and neurodegenerative diseases. Studies are exploring the complex interactions between APOA5 and various physiological processes to further understand its diverse functions.

Can APOA5 protein be used as a biomarker for cardiovascular risk assessment? 02/14/2017

While APOA5 protein levels have been studied as a potential biomarker for cardiovascular risk assessment, its clinical utility as a standalone biomarker is not yet well-established. It may have more value when combined with other lipid markers and risk factors for a comprehensive assessment.

Are there any known disorders or diseases associated with mutations or changes in the APOA5 gene? 07/20/2016

Yes, mutations or changes in the APOA5 gene have been associated with certain lipid disorders and cardiovascular diseases. These include hypertriglyceridemia (high triglyceride levels), familial combined hyperlipidemia, metabolic syndrome, and an increased risk of coronary artery disease.

How does APOA5 protein influence triglyceride metabolism? 03/27/2016

APOA5 protein interacts with enzymes involved in triglyceride metabolism, such as lipoprotein lipase (LPL), and affects their activity. It modulates the breakdown of triglycerides in circulating lipoproteins, influencing the levels of triglycerides in the blood.

Customer Reviews (4)

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Reviews
01/24/2023

    The manufacturer of APOA5 protein has consistently provided outstanding technical support that has surpassed my expectations.

    05/15/2021

      This protein demonstrates remarkable purity, stability, and specificity, ensuring utmost accuracy and reproducibility in my research endeavors.

      07/23/2020

        I am delighted to express my complete satisfaction with the quality of APOA5 protein, as it precisely suits my experimental requirements.

        11/24/2018

          Their dedication to customer satisfaction has been instrumental in overcoming obstacles and achieving successful results in my experiments.

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