Recombinant Rat Ctf1 protein
Cat.No. : | Ctf1-1174R |
Product Overview : | Recombinant Rat Ctf1 protein was expressed in Escherichia coli. |
- Specification
- Gene Information
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Description : | Cardiotrophin1 (CT1) is a member of the cytokine family which also includes IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), and ciliary neurotrophic factor (CNTF). CT-1 is a pleiotropic cytokine which is expressed in various tissues including the adult heart, skeletal muscle, ovary, colon, prostate and fetal lung. Studies showed CT-1 which induces cardiac myocyte hypertrophy in vitro can bind to and activate the ILST/gp130 receptor. Rat CT1 encodes a 203 amino acid (a.a.) residue protein that lacks a hydrophobic signal peptide and it shares 94% a.a. and 79% a.a. sequence identity with human and murine CT-1. |
Source : | E.coli |
Species : | Rat |
Form : | Lyophilized from a 0.2μm filtered concentrated solution in 30 % Acetonitrile, 0.1 % TFA. |
Bio-activity : | Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human TF-1 cells is less than 0.5 ng/ml, corresponding to a specific activity of > 2.0 × 10⁶ IU/mg. |
Molecular Mass : | Approximately 21.4 kDa, a single non-glycosylated polypeptide chain containing 203 amino acids. |
Protein length : | 203 |
AA Sequence : | MSQREGSLEDHQTDSSFSFLPHLEA KIRQTHNLARLLTKYADQLLEEYVQ QQGEPFGLPGFSPPRLPLAGLSGPA PSHAGLPVSERLRQDAAALSALPAL LDAVRRRQAELNPRAPRLLRSLEDA ARQVRALGAAVETVLAALGAAARGP VPEPVATSALFTSNSAAGVFSAKVL GLHVCGLYGEWVSRTEGDLGQLVPG GVA |
Endotoxin : | Less than 1 EU/μg of rRtCT-1 as determined by LAL method. |
Purity : | >95% by SDS-PAGE and HPLC analysis. |
Storage : | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution. |
Reconstitution : | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in 4mM HCl to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤-20 centigrade. Further dilutions should be made in appropriate buffered solutions. |
Gene Name : | Ctf1 |
Official Symbol : | Ctf1 |
Synonyms : | CTF1; cardiotrophin 1; cardiotrophin-1; CT-1; |
Gene ID : | 29201 |
mRNA Refseq : | NM_017129 |
Protein Refseq : | NP_058825 |
UniProt ID : | Q63086 |
Products Types
◆ Recombinant Protein | ||
CTF1-1312R | Recombinant Rat CTF1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Ctf1-191C | Active Recombinant Mouse Ctf1 Protein (202 aa) | +Inquiry |
CTF1-238H | Active Recombinant Human CTF1 protein(Ser2-Ala201) | +Inquiry |
Ctf1-1286M | Recombinant Mouse Ctf1 Protein, His-tagged | +Inquiry |
CTF1-2067H | Recombinant Human CTF1 Protein, GST-tagged | +Inquiry |
◆ Lysates | ||
CTF1-001HCL | Recombinant Human CTF1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionCTF1 plays a role in metabolic regulation, impacting processes related to obesity and diabetes.
CTF1 supports neuronal survival and regeneration, offering potential benefits in neurodegenerative conditions.
CTF1 promotes cardiac hypertrophy and can contribute to heart failure progression by influencing heart muscle cell growth.
Changes in CTF1 expression are important for tissue repair and regeneration, particularly following injury.
CTF1 aids in muscle regeneration and can be involved in the pathology of muscle wasting diseases.
CTF1 activates the JAK/STAT signaling pathway, affecting cell growth, differentiation, and survival.
CTF1 influences inflammatory and immune responses, potentially impacting autoimmune disease mechanisms.
Customer Reviews (3)
Write a reviewSwift protein characterization services; key for our research projects.
Expertise in protein engineering; invaluable for our lab's needs.
High-quality protein-protein interaction assays; essential for our experiments.
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