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Recombinant Rat Ctf1 protein

Cat.No. : Ctf1-1174R
Product Overview : Recombinant Rat Ctf1 protein was expressed in Escherichia coli.
  • Specification
  • Gene Information
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Description : Cardiotrophin­1 (CT­1) is a member of the cytokine family which also includes IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), and ciliary neurotrophic factor (CNTF). CT-1 is a pleiotropic cytokine which is expressed in various tissues including the adult heart, skeletal muscle, ovary, colon, prostate and fetal lung. Studies showed CT-1 which induces cardiac myocyte hypertrophy in vitro can bind to and activate the ILST/gp130 receptor. Rat CT­1 encodes a 203 amino acid (a.a.) residue protein that lacks a hydrophobic signal peptide and it shares 94% a.a. and 79% a.a. sequence identity with human and murine CT-1.
Source : E.coli
Species : Rat
Form : Lyophilized from a 0.2μm filtered concentrated solution in 30 % Acetonitrile, 0.1 % TFA.
Bio-activity : Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human TF-1 cells is less than 0.5 ng/ml, corresponding to a specific activity of > 2.0 × 10⁶ IU/mg.
Molecular Mass : Approximately 21.4 kDa, a single non-glycosylated polypeptide chain containing 203 amino acids.
Protein length : 203
AA Sequence : MSQREGSLEDHQTDSSFSFLPHLEA KIRQTHNLARLLTKYADQLLEEYVQ QQGEPFGLPGFSPPRLPLAGLSGPA PSHAGLPVSERLRQDAAALSALPAL LDAVRRRQAELNPRAPRLLRSLEDA ARQVRALGAAVETVLAALGAAARGP VPEPVATSALFTSNSAAGVFSAKVL GLHVCGLYGEWVSRTEGDLGQLVPG GVA
Endotoxin : Less than 1 EU/μg of rRtCT-1 as determined by LAL method.
Purity : >95% by SDS-PAGE and HPLC analysis.
Storage : Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Reconstitution : We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in 4mM HCl to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤-20 centigrade. Further dilutions should be made in appropriate buffered solutions.
Gene Name : Ctf1
Official Symbol : Ctf1
Synonyms : CTF1; cardiotrophin 1; cardiotrophin-1; CT-1;
Gene ID : 29201
mRNA Refseq : NM_017129
Protein Refseq : NP_058825
UniProt ID : Q63086

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does CTF1 contribute to metabolic regulation, particularly in obesity and diabetes? 10/22/2022

CTF1 plays a role in metabolic regulation, impacting processes related to obesity and diabetes.

What are the effects of CTF1 on neuronal survival and regeneration in neurodegenerative diseases? 05/20/2022

CTF1 supports neuronal survival and regeneration, offering potential benefits in neurodegenerative conditions.

How does CTF1 influence cardiac hypertrophy and heart failure progression? 04/22/2022

CTF1 promotes cardiac hypertrophy and can contribute to heart failure progression by influencing heart muscle cell growth.

How do alterations in CTF1 expression affect tissue repair and regeneration after injury? 05/16/2021

Changes in CTF1 expression are important for tissue repair and regeneration, particularly following injury.

What role does CTF1 play in the regulation of muscle regeneration and muscle wasting diseases? 08/05/2020

CTF1 aids in muscle regeneration and can be involved in the pathology of muscle wasting diseases.

How does CTF1 interact with the JAK/STAT signaling pathway in different cell types? 08/25/2019

CTF1 activates the JAK/STAT signaling pathway, affecting cell growth, differentiation, and survival.

What is the impact of CTF1 in inflammatory responses and autoimmune diseases? 08/14/2019

CTF1 influences inflammatory and immune responses, potentially impacting autoimmune disease mechanisms.

Customer Reviews (3)

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Reviews
08/19/2022

    Swift protein characterization services; key for our research projects.

    09/28/2019

      Expertise in protein engineering; invaluable for our lab's needs.

      08/31/2019

        High-quality protein-protein interaction assays; essential for our experiments.

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