Active Recombinant Rat Dyrk1a protein, GST-tagged

• Cat.No.: DYRK1A-1990R
• Product Overview: Recombinant Rat Dyrk1a fused with GST tag at N-terminal was expressed in E. coli.

Specification

• Description: DYRK1 A or dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A is a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family which contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. DYRK1A participates in various cellular processes. DYRK1A is a highly conserved gene located in the so-called Down Syndrome critical region (DSCR) on part of chromosome 21 that is responsible for the majority of phenotypic features in Down syndrome (1). DYRK1A plays a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. DYRK1A is also contributing to early onset of Alzheimer disease.
• Source: E. coli
• Species: Rat
• Tag: GST
• Form: 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Bio-activity: 1200 nmol/min/mg
• Molecular Mass: ~100 kDa
• Purity: >70%
• Applications: Kinase Assay, Western Blot
• Stability: 1 year at -70 centigrade from the date of shipment
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: Dyrk1a dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A [ Rattus norvegicus ]
• Official Symbol: Dyrk1a
• Synonyms: DYRK1A; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A; dual specificity tyrosine-phosphorylation-regulated kinase 1A; MNBH; RP86; protein kinase minibrain homolog; Dual Specificity Yak1-related kinase; Dyrk; PSK47
• Gene ID: 25255
• mRNA Refseq: NM_012791
• Protein Refseq: NP_036923
• UniProt ID: Q63470
• Chromosome Location: 11q11
• Pathway: Hedgehog Signaling Pathway, organism-specific biosystem
• Function: ATP binding; non-membrane spanning protein tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein self-association; protein self-association; protein serine/threonine kinase activity; protein tyrosine kinase activity