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Recombinant Rat Hif1a protein, His-tagged

Cat.No. : Hif1a-7720R
Product Overview : Recombinant Rat Hif1a aa. (Ser641~Asn810 (Accession # O35800)) fused with N-terminal His tag was produced in E. coli cells.
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  • Gene Information
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Source : E. coli
Species : Rat
Tag : His
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 20.2kDa
Protein length : Ser641~Asn810 (Accession # O35800)
Endotoxin : <1.0EU per 1µg (determined by the LAL method)
Purity : >95%
Characteristic : The isoelectric point is 8.6.
Applications : SDS-PAGE; WB; ELISA; IP.
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Storage buffer : Supplied as lyophilized form in PBS, pH7.4, containing 5% sucrose, 0.01% sarcosyl.
Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4.
Gene Name : Hif1a hypoxia inducible factor 1 alpha subunit [ Rattus norvegicus (Norway rat) ]
Official Symbol : Hif1a
Synonyms : MOP1; hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); hypoxia-inducible factor 1 alpha; hypoxia-inducible factor 1-alpha
Gene ID : 29560
mRNA Refseq : NM_024359.1
Protein Refseq : NP_077335.1
UniProt ID : O35800

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does HIF1A contribute to metabolic reprogramming in cells? 09/01/2022

HIF1A shifts cellular metabolism from oxidative phosphorylation to glycolysis, conserving oxygen but producing less energy.

How does HIF1A influence immune responses under hypoxic conditions? 07/10/2021

HIF1A modulates immune cell function, influencing responses like inflammation and immune cell migration in hypoxic tissues.

What role does HIF1A play in angiogenesis? 04/28/2021

HIF1A upregulates the expression of angiogenic factors, promoting blood vessel formation to improve oxygen supply.

In what way is HIF1A implicated in cancer progression? 09/14/2020

In cancer, HIF1A promotes tumor growth, survival, and metastasis under low oxygen conditions.

What is the primary function of HIF1A in response to hypoxia? 08/27/2018

HIF1A activates the transcription of genes involved in oxygen delivery and metabolic adaptation to hypoxia.

How is HIF1A regulated at the post-translational level? 06/17/2018

Under normoxic conditions, HIF1A is rapidly degraded, but under hypoxia, it stabilizes, translocates to the nucleus, and activates target genes.

What therapeutic strategies are being developed to target HIF1A in diseases? 02/13/2018

Therapeutic strategies targeting HIF1A aim to inhibit its activity in cancer or enhance it in conditions like ischemic heart disease.

Customer Reviews (3)

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Reviews
03/19/2022

    Reliable product, satisfied customer.

    03/28/2021

      Good value for money.

      11/07/2018

        Product exceeded expectations.

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