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Recombinant Rat Hspd1 protein, His-tagged

Cat.No. : Hspd1-243R
Product Overview : Recombinant Rat Hspd1 fused with His tag was expressed in E. coli.
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  • Gene Information
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Description : HSPD1, also known as HSP60, is a member of the chaperonin family. HSPD1 may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. It may also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. HSPD1 gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Several pseudogenes have been associated with this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13.Defects in HSPD1 are a cause of spastic paraplegia autosomal dominant type 13 (SPG13). Spastic paraplegia is a degenerative spinal cord disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Defects in HSPD1 are the cause of leukodystrophy hypomyelinating type 4 (HLD4); also called mitochondrial HSP60 chaperonopathy or MitCHAP-60 disease. HLD4 is a severe autosomal recessive hypomyelinating leukodystrophy. HSPD1 is cinically characterized by infantile-onset rotary nystagmus, progressive spastic paraplegia, neurologic regression, motor impairment, profound mental retardation. Death usually occurrs within the first two decades of life.
Source : E. coli
Species : Rat
Tag : His
Form : Lyophilized from sterile PBS, pH 7.4
Purity : > 95 % as determined by SDS-PAGE
Storage : Store at -70 centigrade. Avoid repeated freeze/thaw cycles.
Gene Name : Hspd1 heat shock protein 1 (chaperonin) [ Rattus norvegicus ]
Official Symbol : Hspd1
Synonyms : HSPD1; heat shock protein 1 (chaperonin); 60 kDa heat shock protein, mitochondrial; CPN60; HSP-60; HSP-65; chaperonin 60; 60 kDa chaperonin; heat shock 60kDa protein 1; heat shock protein 60 (liver); mitochondrial matrix protein P1; heat shock 60kD protein 1 (chaperonin); Hsp60; Hspd1-30p;
Gene ID : 63868
mRNA Refseq : NM_022229
Protein Refseq : NP_071565
UniProt ID : P63039
Chromosome Location : 9q31
Pathway : Legionellosis, organism-specific biosystem; Legionellosis, conserved biosystem; RNA degradation, organism-specific biosystem; RNA degradation, conserved biosystem; SIDS Susceptibility Pathways, organism-specific biosystem; Tuberculosis, organism-specific biosystem; Tuberculosis, conserved biosystem;
Function : ATP binding; cell surface binding; chaperone binding; insulin binding; lipopolysaccharide binding; misfolded protein binding; nucleotide binding; p53 binding; protease binding; protein binding; protein complex binding; protein heterodimerization activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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