Recombinant Rat Il3 protein, His & GST-tagged
Cat.No. : | Il3-643R |
Product Overview : | Recombinant Rat Il3 aa. (Ile27~Cys166 (Accession # P04823)) fused with N-terminal His & GST tag was produced in E. coli cells. |
- Specification
- Gene Information
- Related Products
Source : | E. coli |
Species : | Rat |
Tag : | His & GST |
Form : | Freeze-dried powder |
Molecular Mass : | Predicted Molecular Mass: 45.8kDa |
Protein length : | Ile27~Cys166 (Accession # P04823) |
Endotoxin : | <1.0EU per 1µg (determined by the LAL method) |
Purity : | >90% |
Characteristic : | The isoelectric point is 7.8. |
Applications : | SDS-PAGE; WB; ELISA; IP; CoIP; Purification; Amine Reactive Labeling. |
Stability : | The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. |
Storage buffer : | Supplied as lyophilized form in 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5% trehalose, and preservative |
Reconstitution : | Reconstitute in sterile ddH2O. |
Gene Name : | Il3 interleukin 3 [ Rattus norvegicus (Norway rat) ] |
Official Symbol : | Il3 |
Synonyms : | IL-3; MCGF; P-cell-stimulating factor; hematopoietic growth factor; mast cell growth factor; multipotential colony-stimulating factor; interleukin-3 |
Gene ID : | 24495 |
mRNA Refseq : | NM_031513.1 |
Protein Refseq : | NP_113701.1 |
UniProt ID : | P04823 |
Products Types
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◆ Lysates | ||
IL3-607HCL | Recombinant Human IL3 cell lysate | +Inquiry |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (16)
Ask a questionIn vitro, IL-3 can induce differentiation and proliferation of myeloid lineage cells and is distinguished from GM-CSF by the relative increase in production of platelets, basophils, and mast cells.
Although effective, IL-3 appears to present no therapeutic advantages compared to G-CSF and GM-CSF, and in direct comparison studies, IL-3 led to a considerably higher rate of adverse events than either of the other cytokines.
mice deficient in both bc and IL-3 show the same phenotype as the bc-deficient mice, conclusively demonstrating that, for the most part, the GM-CSF/IL3/IL5 family is not essential for steady-state production of myeloid cells
Unlike in humans, murine IL-3 has a second b chain receptor, bcIL3, which bears 91% homology to the bc chain.
Knockout mice were also reported with surprisingly limited phenotypes. Despite the ability of the three cytokines to stimulate hematopoiesis, mice functionally deficient in all three cytokinesdisplay normal circulating levels of granulocytes, monocytes, and basophils.
non-hematopoietic (e.g., epithelial cells, and fibroblasts) cell subsets can also produce il-3.
Such as allergic inflammation and parasitic infestation.
IL-3 can regulate the survival of basophil granulocytes and cytokine production through autocrine, so as to achieve the purpose of treating allergic diseases.
Bhlhe40
E.g., lymphocytes,epithelial cells, and fibroblasts
Yes, there are some completed clinical trials on IL3 results, but the specific results need to refer to the relevant research papers.
This protein can promote stem cell proliferation and differentiation during hematopoietic process, thus increasing the production of different types of blood cells.
In general, the IL3 has relatively few side effects, but some unpleasant symptoms such as fever, headache and nausea may occur.
IL3 can regulate the body's immune response and the function of immune cells, and plays an important role in immune regulation.
IL3 generally have good solubility and stability, making them easier to handle during drug preparation and storage.
The study of IL3 is ongoing, including its application in the development of therapeutic drugs, as well as in combination therapy with other immune molecules.
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Write a reviewI've used many brands, but this one is one of my favorites.
The performance is very stable and the price is very reasonable. I would definitely buy this product again.
I have recommended this brand to my colleagues and friends, and they all praise this product.
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