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Recombinant Rat Npy protein, His & GST-tagged

Cat.No. : Npy-7870R
Product Overview : Recombinant Rat Npy aa. (Pro31~Trp98) fused with N-terminal His & GST tag was produced in E. coli cells.
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  • Gene Information
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Description : This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. Studies in the rat model of depression (Flinders Sensitive Line) show that this gene is downregulated in the hippocampus and the prefrontal cortex compared to the control ((Flinders Resistant Line). Alternatively spliced transcript variants of this gene have been described, but the function of all the variants is not known.
Source : E. coli
Species : Rat
Tag : His & GST
Form : Freeze-dried powder
Molecular Mass : 38kDa as determined by SDS-PAGE reducing conditions.
Protein length : Pro31~Trp98
Endotoxin : <1.0EU per 1µg (determined by the LAL method)
Purity : >92%
Characteristic : The isoelectric point is 6.4.
Applications : SDS-PAGE; WB; ELISA; IP; CoIP; Purification; Amine Reactive Labeling.
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Concentration : 200μg/mL
Storage buffer : PBS, pH7.4, containing 1mM DTT, 5% trehalose, 0.01% sarcosyl and Proclin300
Reconstitution : Reconstitute in PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
Gene Name : Npy neuropeptide Y [ Rattus norvegicus (Norway rat) ]
Official Symbol : Npy
Synonyms : NPY02; RATNPY; RATNPY02; pro-neuropeptide Y
Gene ID : 24604
mRNA Refseq : NM_012614.2
Protein Refseq : NP_036746.1
UniProt ID : P07808

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any NPY-based therapies for depression? 04/30/2021

While there are currently no NPY-based therapies approved for depression, research is exploring the potential of targeting NPY pathways for novel antidepressant treatments.

How does NPY protein relate to epilepsy? 06/26/2020

NPY has been shown to have anticonvulsant properties and may play a role in regulating seizure activity in the brain.

Can NPY protein be used in the treatment of epilepsy? 03/24/2020

Research suggests that NPY-based therapies may have potential in the treatment of epilepsy, although more studies are needed.

How does NPY protein affect anxiety? 05/25/2018

NPY has been found to have an anxiolytic effect, meaning it can reduce anxiety and stress levels in the brain.

Are there any other neurological disorders that NPY protein may be relevant to? 05/16/2016

NPY has also been implicated in neurodegenerative disorders, such as Alzheimer's disease, and is being studied for its potential neuroprotective effects.

Customer Reviews (3)

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Reviews
10/24/2020

    This aspect is crucial in maintaining the scientific rigor of my studies and strengthens the validity of my research findings.

    09/27/2020

      the manufacturer's commitment to continuous improvement and innovation is evident in their constant efforts to enhance the NPY protein.

      01/02/2016

        Its high purity and integrity ensure reliable and reproducible results, minimizing any potential variability in my experimental outcomes.

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