Recombinant Rat Pfn1 protein, His-tagged
Cat.No. : | Pfn1-56R |
Product Overview : | Recombinant rat Pfn1, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
- Specification
- Gene Information
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Description : | Pfn1 also known as Profilin-1 is a ubiquitous actin monomer-binding protein belonging to the profilin family. This protein significantly enhances skin wound healing in-vitro and in-vivo that may be mediated by purinergic receptors. It is also active in endothelial cell migration and vessel sprouting. It is thought to regulate actin polymerization in response to extracellular signals. |
Source : | E. coli |
Species : | Rat |
Tag : | His |
Form : | Liquid. In Phosphate Buffered Saline(pH 7.4) containing 10% glycerol 1mM DTT |
Molecular Mass : | 17.5 kDa (164aa) confirmed by MALDI-TOF |
AA Sequence : | MGSSHHHHHH SSGLVPRGSH MGSHMAGWNA YIDSLMADGT CQDAAIVGYK DSPSVWAAVP GKTFVSITPA EVGVLVGKDR SSFFVNGLTL GGQKCSVIRD SLLQDGEFTM DLRTKSTGGA PTFNVTVTMT AKTLVLLMGK EGVHGGLINK KCYEMASHLR RSQY |
Purity : | >95% by SDS - PAGE |
Storage : | Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles. |
Concentration : | 1mg/ml (determined by Absorbance at 280nm) |
Gene Name : | Pfn1 profilin 1 [ Rattus norvegicus ] |
Official Symbol : | Pfn1 |
Synonyms : | PFN1; profilin 1; profilin-1; profilin I; |
Gene ID : | 64303 |
mRNA Refseq : | NM_022511 |
Protein Refseq : | NP_071956 |
MIM : | |
UniProt ID : | |
Pathway : | Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; G13 Signaling Pathway, organism-specific biosystem; Regulation of Actin Cytoskeleton, organism-specific biosystem; Regulation of actin cytoskeleton, organism-specific biosystem; Regulation of actin cytoskeleton, conserved biosystem; Salmonella infection, organism-specific biosystem; |
Function : | Rho GTPase binding; Rho GTPase binding; actin binding; actin binding; phosphatidylinositol-4,5-bisphosphate binding; proline-rich region binding; proline-rich region binding; protein binding; receptor binding; |
Products Types
◆ Recombinant Protein | ||
PFN1-527C | Recombinant Cynomolgus Monkey PFN1 Protein, His (Fc)-Avi-tagged | +Inquiry |
PFN1-1655H | Recombinant Human PFN1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Pfn1-4812M | Recombinant Mouse Pfn1 Protein, Myc/DDK-tagged | +Inquiry |
PFN1-6655M | Recombinant Mouse PFN1 Protein, His (Fc)-Avi-tagged | +Inquiry |
PFN1-01H | Recombinant Human PFN1 Protein (mutant C71G) | +Inquiry |
◆ Lysates | ||
PFN1-3269HCL | Recombinant Human PFN1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYes, PFN1 is involved in processes such as endocytosis, cytokinesis, and cell signaling, highlighting its importance in various cellular functions.
Research on targeting PFN1 in cancer therapy is ongoing, and there are clinical trials exploring potential drugs that could inhibit PFN1 activity to impede cancer cell metastasis.
PFN1 has been found to promote cancer cell migration and invasion, suggesting its role in cancer metastasis, making it a potential target for cancer therapy.
Yes, researchers are exploring the potential of developing drugs that target PFN1 to modulate its activity, especially in the context of cancer metastasis and neurodegenerative disorders.
PFN1 regulates cell motility and migration by controlling the dynamics of actin filaments, essential components of the cell's cytoskeleton involved in cell movement.
Customer Reviews (3)
Write a reviewThe manufacturer ensures that the protein is produced with utmost purity and integrity, minimizing the risk of experimental artifacts or compromised results.
Their excellent technical support, commitment to scientific collaboration, and efficient supply chain management greatly contribute to the success and productivity of my research.
One of the key advantages of using PFN1 protein in trials is its high quality.
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