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Recombinant Rat Pfn1 protein, His-tagged

Cat.No. : Pfn1-56R
Product Overview : Recombinant rat Pfn1, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
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  • Gene Information
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Description : Pfn1 also known as Profilin-1 is a ubiquitous actin monomer-binding protein belonging to the profilin family. This protein significantly enhances skin wound healing in-vitro and in-vivo that may be mediated by purinergic receptors. It is also active in endothelial cell migration and vessel sprouting. It is thought to regulate actin polymerization in response to extracellular signals.
Source : E. coli
Species : Rat
Tag : His
Form : Liquid. In Phosphate Buffered Saline(pH 7.4) containing 10% glycerol 1mM DTT
Molecular Mass : 17.5 kDa (164aa) confirmed by MALDI-TOF
AA Sequence : MGSSHHHHHH SSGLVPRGSH MGSHMAGWNA YIDSLMADGT CQDAAIVGYK DSPSVWAAVP GKTFVSITPA EVGVLVGKDR SSFFVNGLTL GGQKCSVIRD SLLQDGEFTM DLRTKSTGGA PTFNVTVTMT AKTLVLLMGK EGVHGGLINK KCYEMASHLR RSQY
Purity : >95% by SDS - PAGE
Storage : Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles.
Concentration : 1mg/ml (determined by Absorbance at 280nm)
Gene Name : Pfn1 profilin 1 [ Rattus norvegicus ]
Official Symbol : Pfn1
Synonyms : PFN1; profilin 1; profilin-1; profilin I;
Gene ID : 64303
mRNA Refseq : NM_022511
Protein Refseq : NP_071956
MIM :
UniProt ID :
Pathway : Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; G13 Signaling Pathway, organism-specific biosystem; Regulation of Actin Cytoskeleton, organism-specific biosystem; Regulation of actin cytoskeleton, organism-specific biosystem; Regulation of actin cytoskeleton, conserved biosystem; Salmonella infection, organism-specific biosystem;
Function : Rho GTPase binding; Rho GTPase binding; actin binding; actin binding; phosphatidylinositol-4,5-bisphosphate binding; proline-rich region binding; proline-rich region binding; protein binding; receptor binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Is PFN1 protein involved in any other cellular processes apart from cell motility? 11/09/2021

Yes, PFN1 is involved in processes such as endocytosis, cytokinesis, and cell signaling, highlighting its importance in various cellular functions.

Are there ongoing clinical trials targeting PFN1 for cancer treatment? 09/30/2020

Research on targeting PFN1 in cancer therapy is ongoing, and there are clinical trials exploring potential drugs that could inhibit PFN1 activity to impede cancer cell metastasis.

How does PFN1 protein contribute to cancer progression? 05/30/2020

PFN1 has been found to promote cancer cell migration and invasion, suggesting its role in cancer metastasis, making it a potential target for cancer therapy.

Can PFN1 protein be targeted for drug development? 12/22/2019

Yes, researchers are exploring the potential of developing drugs that target PFN1 to modulate its activity, especially in the context of cancer metastasis and neurodegenerative disorders.

How does PFN1 protein affect cell motility and migration? 05/03/2016

PFN1 regulates cell motility and migration by controlling the dynamics of actin filaments, essential components of the cell's cytoskeleton involved in cell movement.

Customer Reviews (3)

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Reviews
08/26/2021

    The manufacturer ensures that the protein is produced with utmost purity and integrity, minimizing the risk of experimental artifacts or compromised results.

    06/22/2021

      Their excellent technical support, commitment to scientific collaboration, and efficient supply chain management greatly contribute to the success and productivity of my research.

      11/09/2020

        One of the key advantages of using PFN1 protein in trials is its high quality.

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