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Recombinant Cynomolgus/Rhesus macaque B2M protein, His-tagged

Cat.No. : B2M-488R
Product Overview : Recombinant Cynomolgus/Rhesus macaque B2M protein (Ile21-Met119), fused to His tag at C-terminus, was expressed in human 293 cells (HEK293).In the region Ile21-Met119, the AA sequence of Cynomolgus and Rhesus macaque B2M are homologus.
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Description : β2 microglobulin is also known as Beta-2-microglobulin (B2M), is a component of MHC class I molecules which belongs to the beta-2-microglobulin family. B2M is present on all nucleated cells (excludes red blood cells). B2M associates not only with the alpha chain of MHC class I molecules, but also with class I-like molecules such as CD1 and Qa. An additional function of B2M is association with the HFE protein, together regulating the expression of hepcidin in the liver which targets the iron transporter ferroportin on the cytoplasmic membrane of enterocytes and macrophages for degradation resulting in decreased iron uptake from food and iron release from recycled red blood cells respectively. Loss of this function causes iron excess and hemochromatosis. Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP).
Source : HEK293
Species : Cynomolgus/Rhesus macaque
Tag : His
Form : Lyophilized from 0.22 um filtered solution in PBS, pH7.4, 10% trehalose.
Molecular Mass : The protein has a calculated MW of 12.6 kDa. The protein migrates as 14 kDa under reducing (R) condition (SDS-PAGE).
Protein length : 99
Endotoxin : Less than 1.0 EU per ug by the LAL method.
Purity : >95% as determined by SDS-PAGE.
Storage : For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 centigrade to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : B2M
Official Symbol : B2M
Synonyms : B2M; beta-2-microglobulin; beta-2-microglobin; beta chain of MHC class I molecules
Gene ID : 712428
mRNA Refseq : NM_001047137.1
Protein Refseq : NP_001040602.1
UniProt ID : Q6V7J5

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What is the normal reference range for B2M? 11/19/2019

The normal reference range for B2M varies depending on age, gender, weight, individual differences, and other factors. In general, the normal reference range is between 0~3.0mg/L.

Why is B2M reduced? 11/16/2019

Causes of reduced B2M include liver and kidney failure, tuberculosis, HIV infection, rheumatoid arthritis, systemic lupus erythematosus and other diseases.

In which diseases does B2M play a role in the diagnosis and treatment? 09/20/2019

B2M plays an important role in the diagnosis and prognosis assessment of malignancies such as lymphoma and multiple myeloma. Elevated B2M levels can also indicate worsening or recurrence of certain autoimmune diseases, such as systemic lupus erythematosus.

What are the physiological functions of B2M? 07/29/2019

It has a variety of physiological functions in the immune system, including inducing immune response, participating in lymphocyte proliferation and differentiation, regulating immune tolerance, and participating in tumor immune surveillance.

What are the causes of elevated B2M? 06/05/2019

The levels can be affected by a variety of factors, such as cancer, inflammation, autoimmune diseases, infections, medications, etc.

How is B2M related to disease? 04/30/2019

This is associated with many diseases, including lymphoma, normal stress hydrocephalus, HIV infection, rheumatoid arthritis, nephrotic syndrome, cirrhosis, systemic lupus erythematosus, etc.

Customer Reviews (3)

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Reviews
10/08/2022

    To meet the needs of biological activity experiments

    01/25/2022

      High purity, no impurities.

      09/10/2020

        The expression level is high, which can meet the daily experimental needs.

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