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Recombinant Rhesus macaque TFPI protein, His-tagged

Cat.No. : TFPI-4683R
Product Overview : Recombinant Rhesus macaque TFPI protein (Asp29-Lys282), fused to His tag at C-terminus, was expressed in human 293 cells (HEK293).
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Description : Tissue factor pathway inhibitor (TFPI) is also known as Extrinsic pathway inhibitor (EPI), Lipoprotein - associated coagulation inhibitor (LACI), is a plasma proteinase inhibitor synthesized by vascular endothelial cells and part of it is associated with glycosaminoglycans of these cells. TFPI is a single-chain polypeptide which can reversibly inhibit Factor Xa (Xa) and Thrombin (Factor IIa). TFPI is a secreted protein with a N­terminal acidic region, three Kunitz (K) domains separated with by two linker regions, and a C­terminal basic region. The first K domain inhibits coagulation factor VIIa complexed to tissue factor (TF); The second K domain inhibits factor Xa; The third K domain binds to heparin; The C­terminal basic region may have several functions. For example, it plays an important role in binding of TFPI to cell surfaces.
Source : HEK293
Species : Rhesus macaque
Tag : His
Form : Lyophilized from 0.22 um filtered solution in PBS, pH7.4, 10% trehalose.
Molecular Mass : The protein has a calculated MW of 31.1 kDa. The protein migrates as 41-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Protein length : 254
Endotoxin : Less than 1.0 EU per ug by the LAL method.
Purity : >95% as determined by SDS-PAGE.
Storage : For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 centigrade to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : TFPI
Official Symbol : TFPI
Synonyms : EPI; LACI
Gene ID : 613026
mRNA Refseq : NM_001195022.1
Protein Refseq : NP_001181951.1
UniProt ID : I0FUM5

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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In which medical scenarios is monitoring TFPI protein particularly crucial? 06/20/2022

Monitoring TFPI levels is crucial in patients with a history of thrombotic events, individuals at high risk of clotting disorders, and those undergoing anticoagulant therapy.

Can TFPI protein be explored in the context of preventing complications in surgery or other medical procedures? 01/23/2022

Research suggests that manipulating TFPI levels might be explored to reduce thrombotic complications in surgical and medical settings, potentially improving patient outcomes.

Are there any challenges or risks associated with manipulating TFPI levels for therapeutic purposes? 07/27/2019

Manipulating TFPI levels may pose challenges, as it could potentially lead to bleeding disorders. Balancing the anticoagulant effects with the risk of bleeding is a critical consideration.

How does TFPI contribute to the regulation of inflammation in addition to its anticoagulant properties? 03/11/2017

TFPI has anti-inflammatory effects by inhibiting the activation of immune cells and downregulating inflammatory mediators. This dual role makes it a potential therapeutic target in conditions involving both coagulation and inflammation.

In what ways can TFPI protein be a target for drug development in the pharmaceutical industry? 04/22/2016

Pharmaceutical research can explore the development of drugs that either enhance or mimic the activity of TFPI, providing new avenues for anticoagulant therapies.

Customer Reviews (3)

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Reviews
03/04/2022

    This property is particularly beneficial for long-term trials or experiments with extended durations, ensuring consistent performance throughout the entire study period.

    05/31/2020

      Its purity and consistency have been extensively validated, minimizing any potential variability that could affect trial outcomes.

      07/22/2016

        Their extensive technical expertise and assistance are invaluable in overcoming any challenges that may arise during the experimental process.

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