Recombinant Rhesus macaque TFPI protein, His-tagged
Cat.No. : | TFPI-4683R |
Product Overview : | Recombinant Rhesus macaque TFPI protein (Asp29-Lys282), fused to His tag at C-terminus, was expressed in human 293 cells (HEK293). |
- Specification
- Gene Information
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Description : | Tissue factor pathway inhibitor (TFPI) is also known as Extrinsic pathway inhibitor (EPI), Lipoprotein - associated coagulation inhibitor (LACI), is a plasma proteinase inhibitor synthesized by vascular endothelial cells and part of it is associated with glycosaminoglycans of these cells. TFPI is a single-chain polypeptide which can reversibly inhibit Factor Xa (Xa) and Thrombin (Factor IIa). TFPI is a secreted protein with a Nterminal acidic region, three Kunitz (K) domains separated with by two linker regions, and a Cterminal basic region. The first K domain inhibits coagulation factor VIIa complexed to tissue factor (TF); The second K domain inhibits factor Xa; The third K domain binds to heparin; The Cterminal basic region may have several functions. For example, it plays an important role in binding of TFPI to cell surfaces. |
Source : | HEK293 |
Species : | Rhesus macaque |
Tag : | His |
Form : | Lyophilized from 0.22 um filtered solution in PBS, pH7.4, 10% trehalose. |
Molecular Mass : | The protein has a calculated MW of 31.1 kDa. The protein migrates as 41-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Protein length : | 254 |
Endotoxin : | Less than 1.0 EU per ug by the LAL method. |
Purity : | >95% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 centigrade to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | TFPI |
Official Symbol : | TFPI |
Synonyms : | EPI; LACI |
Gene ID : | 613026 |
mRNA Refseq : | NM_001195022.1 |
Protein Refseq : | NP_001181951.1 |
UniProt ID : | I0FUM5 |
Products Types
◆ Recombinant Protein | ||
TFPI-752H | Recombinant Human TFPI Protein | +Inquiry |
Tfpi-981M | Active Recombinant Mouse Tfpi protein(Met1-Lys289), His-tagged | +Inquiry |
TFPI-1246H | Recombinant Human TFPI Protein, His-tagged | +Inquiry |
TFPI-707H | Recombinant Human TFPI Protein, MYC/DDK-tagged | +Inquiry |
TFPI-753R | Recombinant Rhesus macaque TFPI Protein | +Inquiry |
◆ Lysates | ||
TFPI-2843MCL | Recombinant Mouse TFPI cell lysate | +Inquiry |
TFPI-2746HCL | Recombinant Human TFPI cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionMonitoring TFPI levels is crucial in patients with a history of thrombotic events, individuals at high risk of clotting disorders, and those undergoing anticoagulant therapy.
Research suggests that manipulating TFPI levels might be explored to reduce thrombotic complications in surgical and medical settings, potentially improving patient outcomes.
Manipulating TFPI levels may pose challenges, as it could potentially lead to bleeding disorders. Balancing the anticoagulant effects with the risk of bleeding is a critical consideration.
TFPI has anti-inflammatory effects by inhibiting the activation of immune cells and downregulating inflammatory mediators. This dual role makes it a potential therapeutic target in conditions involving both coagulation and inflammation.
Pharmaceutical research can explore the development of drugs that either enhance or mimic the activity of TFPI, providing new avenues for anticoagulant therapies.
Customer Reviews (3)
Write a reviewThis property is particularly beneficial for long-term trials or experiments with extended durations, ensuring consistent performance throughout the entire study period.
Its purity and consistency have been extensively validated, minimizing any potential variability that could affect trial outcomes.
Their extensive technical expertise and assistance are invaluable in overcoming any challenges that may arise during the experimental process.
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