Recombinant Streptococcus pneumoniae PLY Protein, His/sumo tagged
| Cat.No. : | PLY-25S |
| Product Overview : | Recombinant Streptococcus pneumoniae PLY Protein with His/sumo tag was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
| Description : | A cholesterol-dependent toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol is required for binding to host membranes, membrane insertion and pore formation; cholesterol binding is mediated by a Thr-Leu pair in the C-terminus. Can be reversibly inactivated by oxidation. |
| Source : | E. coli |
| Species : | Streptococcus pneumoniae |
| Tag : | His/sumo |
| Molecular Mass : | The protein has a calculated MW of 65.7 kDa. |
| AA Sequence : | MAHHHHHHMSDSEVNQEAKPEVKPE VKPETHINLKVSDGSSEIFFKIKKT TPLRRLMEAFAKRQGKEMDSLRFLY DGIRIQADQTPEDLDMEDNDIIEAH REQIGGGSEFRTANKAVNDFILAMN YDKKKLLTHQGESIENRFIKEGNQL PDEFVVIERKKRSLSTNTSDISVTA TNDSRLYPGALLVVDETLLENNPTL LAVDRAPMTYSIDLPGLASSDSFLQ VEDPSNSSVRGAVNDLLAKWHQDYG QVNNVPARMQYEKITAHSMEQLKVK FGSDFEKTGNSLDIDFNSVHSGEKQ IQIVNFKQIYYTVSVDAVKNPGDVF QDTVTVEDLKQRGISAERPLVYISS VAYGRQVYLKLETTSKSDEVEAAFE ALIKGVKVAPQTEWKQILDNTEVKA VILGGDPSSGARVVTGKVDMVEDLI QEGSRFTADHPGLPISYTTSFLRDN VVATFQNSTDYVETKVTAYRNGDLL LDHSGAYVAQYYITWNELSYDHQGK EVLTPKAWDRNGQDLTAHFTTSIPL KGNVRNLSVKIRECTGLAWEWWRTV YEKTDLPLVRKRTISIWGTTLYPQV EDKVEND |
| Purity : | > 90% by SDS-PAGE |
| Storage : | Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Concentration : | 0.6 mg/mL |
| Storage Buffer : | 20 mM Tris-HCl, 0.5M NaCl, pH 8.0, 10% glycerol |
| Gene Name : | ply cholesterol-dependent cytolysin pneumolysin [ Streptococcus pneumoniae ] |
| Official Symbol : | ply |
| Synonyms : | ply cholesterol-dependent cytolysin pneumolysin [ Streptococcus pneumoniae ] |
| Gene ID : | 66806991 |
| Protein Refseq : | WP_001284359 |
| UniProt ID : | P11990 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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