Address: 45-16 Ramsey Road Shirley, NY 11967, USA    USA: 1-631-559-9269   Fax: 1-631-938-8127
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GPCR

G protein-coupled receptors (GPCRs), also known as seven-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein-linked receptors (GPLR), comprise a large protein family of transmembrane receptors that sense molecules outside the cell and activate inside signal transduction pathways and, ultimately, cellular responses. G protein-coupled receptors are found only in eukaryotes, including yeast, choanoflagellates, and animals. The ligands that bind and activate these receptors include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters, and vary in size from small molecules to peptides to large proteins. G protein-coupled receptors are involved in many diseases, and are also the target of approximately 40% of all modern medicinal drugs. There are two principal signal transduction pathways involving the G protein-coupled receptors: the cAMP signal pathway and the Phosphatidylinositol signal pathway.

  • 45-16 Ramsey Road, Shirley, NY 11967, USA
    TEL: 1-631-559-9269
    FAX: 1-631-938-8127
    EMAIL: info@creative-biomart.com

    St John's Innovation Centre, Cowley Road, Cambridge CB4 0WS, UK
    TEL: 44-207-048-3343

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