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ACAN

  • Official Full Name

    aggrecan

  • Overview

    This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene. [provided by RefSeq, Jul 2008]
  • Synonyms

    ACAN; aggrecan; AGC1; SEDK; AGCAN; CSPG1; MSK16; CSPGCP; aggrecan core protein; large aggregating proteoglycan; cartilage-specific proteoglycan core protein; chondroitin sulfate proteoglycan core protein 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cattle
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • His|S
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ACAN-102H Active Recombinant Human ACAN, His-tagged Mammalian cells N/A
Human ACAN-671H Active Recombinant Human ACAN Protein, His-tagged Mammalian cells His Val20-Gly675
Human AGC-3238H Recombinant Human AGC, His-tagged, S tagged E.coli His/S 2415
Human ACAN-2888H Recombinant Human Aggrecan, Interglobular Domain, His-tagged E.coli His
Human ACAN-140H Recombinant Human ACAN Protein, GST-Tagged Wheat Germ GST
Human ACAN-420H Recombinant Human ACAN Protein, GST-tagged Wheat Germ GST
Human ACAN-35HCL Recombinant Human ACAN cell lysate N/A
Human ACAN-29H Recombinant Human ACAN Protein, His-tagged E.coli N-His Ala2162-Pro2316
Human ACAN-2409H-B Recombinant Human ACAN Protein Pre-coupled Magnetic Beads HEK293
Human ACAN-0453H Recombinant Human ACAN Protein (Met1-Gly676), C-His-tagged Mammalian cells C-His Met1-Gly676
Human ACAN-912HF Recombinant Full Length Human ACAN Protein, GST-tagged In Vitro Cell Free System GST 721 amino acids
Human ACAN-2409H Recombinant Human ACAN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Acan-1956M Recombinant Mouse Acan protein, His-tagged E.coli His Pro34~Glu147 (Accession # Q61282)
Mouse ACAN-1167M Recombinant Mouse ACAN Protein Mammalian Cell His
Mouse ACAN-241M-B Recombinant Mouse ACAN Protein Pre-coupled Magnetic Beads HEK293
Mouse ACAN-241M Recombinant Mouse ACAN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Acan-3239R Recombinant Rat Acan, His-tagged E.Coli or Yeast His 2162
Rat ACAN-441R Recombinant Rat ACAN Protein Mammalian Cell His
Rat Acan-1957R Recombinant Rat Acan protein, His-tagged E.coli His Pro34~Glu147 (Accession # P07897)
Rat ACAN-96R Recombinant Rat ACAN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ACAN-96R-B Recombinant Rat ACAN Protein Pre-coupled Magnetic Beads HEK293
Cattle ACAN-1955C Recombinant Cattle ACAN protein, His & T7-tagged E.coli His/T7 Glu2066~Arg2316 (Accession # P13608)
Chicken ACAN-6514C Recombinant Chicken ACAN Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ACAN Related Articles
  • ACAN Related Research Area

ACAN involved in several pathways and played different roles in them. We selected most pathways ACAN participated on our site, such as Defective B4GALT1 causes B4GALT1-CDG (CDG-2d), Defective CHST6 causes MCDC1, Defective ST3GAL3 causes MCT12 and EIEE15, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACAN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)ACAN;FMOD;PRELP;KERA;OGN
Defective CHST6 causes MCDC1OGN;FMOD;ACAN;PRELP;KERA
Defective ST3GAL3 causes MCT12 and EIEE15OGN;KERA;ACAN;PRELP;FMOD
Degradation of the extracellular matrixMMP13;CAPNS1;CTSLL;ADAM8A;MMP12;TLDC2;LOC100686744;TIMP2B;CTSL2
DiseaseTLR10;PDCD6IP;DOCK2;HMGA1;CCDC59;NMT1;ELL;AP1S1;OPN1LW
Diseases associated with glycosaminoglycan metabolismPRELP;KERA;OGN;FMOD;ACAN
Diseases of glycosylationPRELP;KERA;OGN;ACAN;FMOD
ECM proteoglycansCOMP;MATN1;ACAN;PTPRS;ITGB3A;COL9A3;BGNB;MATN3B;SPARC

ACAN has several biochemical functions, for example, carbohydrate binding, extracellular matrix structural constituent, hyaluronic acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACAN itself. We selected most functions ACAN had, and list some proteins which have the same functions with ACAN. You can find most of the proteins on our site.

Function Related Protein
carbohydrate bindingMBL1;ACAN;CD209B;GRIFIN;CD34;GFPT1;Pla2r1;DGCR2;PYGB
extracellular matrix structural constituentLUM;COMP;TINAGL1;COL5A3B;CHI3L1;COL4A4;COL27A1B;LAMA4;MATN1
hyaluronic acid bindingBCAN;HAPLN2;VCANB;ACAN;HAPLN3;HAPLN1;TNFAIP6;HAPLN1A;KIAA1199
metal ion bindingNT5DC1;EXTL3;GTF2E1;ZNF547;ZFP593;NOS2B;ZNF786;SMYD4;PAPD7
protein bindingMYO10;POLD1;MRPL45;SERPINB5;PDCL;BEND5;EZR;SOCS1;TEN1

ACAN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACAN here. Most of them are supplied by our site. Hope this information will be useful for your research of ACAN.

PCOLCE

Li, J; Xie, ZG; et al. Calcitonin treatment is associated with less severe osteoarthritis and reduced toll-like receptor levels in a rat model. JOURNAL OF ORTHOPAEDIC SCIENCE 19:1019-1027(2014).
Zanotti, S; Canalis, E; et al. Interleukin 6 mediates selected effects of Notch in chondrocytes. OSTEOARTHRITIS AND CARTILAGE 21:1766-1773(2013).
  • Q&As
  • Reviews

Q&As (10)

Ask a question
What are some challenges in studying ACAN protein and osteoarthritis? 11/15/2022

One major challenge is the complex nature of the disease, which involves multiple factors and pathways. Additionally, the high heterogeneity of cartilage tissue and the difficulty in obtaining samples pose challenges for experimental studies. Another challenge is the limited understanding of the molecular mechanisms underlying the degradation and synthesis of ACAN protein and its interactions with other matrix molecules and cell surface receptors.

What are the benefits of highly purified recombinant protein? 09/16/2022

A high purity level of recombinant protein is desirable as it ensures the protein's integrity and reduces the risk of impurities or contaminants that may affect its function.

What is the function of ACAN protein in cartilage? 09/05/2022

ACAN protein is a major component of the extracellular matrix of cartilage and plays a critical role in maintaining its structural integrity. ACAN protein helps to maintain the hydration and swelling properties of cartilage by binding to water molecules through its GAG chains. It also interacts with other matrix molecules and cell surface receptors, which contributes to the mechanical properties of cartilage.

What is the structure of ACAN protein? 08/03/2022

ACAN protein is a large proteoglycan consisting of a core protein and long chains of glycosaminoglycans (GAGs), primarily chondroitin sulfate and keratan sulfate. The core protein is composed of several domains, including a signal peptide, a globular domain, and multiple tandem repeats of a hyaluronan-binding domain (HABD).

How to determine the purity level of recombinant ACAN protein? 08/01/2022

The purity level of recombinant protein is typically determined through a combination of different techniques, such as SDS-PAGE, HPLC, and mass spectrometry. The purity level of the protein can vary depending on the production method and the quality control measures in place.

What applications is recombinant ACAN protein suitable for? 03/14/2022

Recombinant ACAN protein is suitable for a variety of applications, including biochemical assays, biophysical studies, and structural biology. The protein can also be used in cell culture experiments and in vitro assays to study its interaction with other proteins and molecules. Additionally, recombinant ACAN protein may have potential applications in tissue engineering and regenerative medicine, where it can be used to create biomaterials for cartilage repair and regeneration.

What is the endotoxin level of recombinant ACAN protein, and how is it tested? 11/11/2021

The endotoxin level of recombinant protein is typically tested using the Limulus amebocyte lysate (LAL) assay. Endotoxins are a type of bacterial cell wall component that can contaminate protein samples, and their presence can affect the function of the protein. A low endotoxin level is desirable for recombinant ACAN protein as it ensures the protein's purity and reduces the risk of contamination. You can select specific recombinant protein endotoxin levels in the inquiry form.

What is the recommended concentration of recombinant ACAN protein for use in cell culture experiments? 08/02/2021

The recommended concentration of recombinant ACAN protein for use in cell culture experiments may vary depending on the specific experimental conditions and cell type used. Typically, a concentration range of 10-100 μg/mL is used.

What are some potential therapeutic strategies targeting ACAN protein for osteoarthritis? 12/12/2020

One potential therapeutic strategy is to use molecules that inhibit the degradation of ACAN protein, such as aggrecanase inhibitors. Another approach is to enhance the synthesis of ACAN protein or its GAG chains, which could be achieved by gene therapy or the use of growth factors. Additionally, tissue engineering approaches that aim to regenerate cartilage by using ACAN protein and other matrix molecules have also been explored.

How does ACAN protein contribute to the development of osteoarthritis? 10/07/2020

During the development of osteoarthritis, ACAN protein is degraded by various enzymes, including matrix metalloproteinases and aggrecanases. This degradation results in a loss of cartilage integrity, decreased hydration and swelling properties, and altered mechanical properties of cartilage, which contribute to the development of osteoarthritis.

Customer Reviews (3)

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Reviews
08/12/2022

    The technical support team at Creative BioMart went above and beyond to customize the ACAN protein to my specific requirements. Their expertise and professionalism were greatly appreciated.

    06/13/2020

      I was thrilled to find the recombinant ACAN protein on sale at such an affordable price.

      02/14/2020

        I highly recommend Creative BioMart to anyone in need of recombinant proteins. Their products are top-notch and their customer service is exceptional.

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