ACIN1

Official Full Name

apoptotic chromatin condensation inducer 1

Background

Apoptosis is defined by several morphologic nuclear changes, including chromatin condensation and nuclear fragmentation. This gene encodes a nuclear protein that induces apoptotic chromatin condensation after activation by caspase-3, without inducing DNA fragmentation. This protein has also been shown to be a component of a splicing-dependent multiprotein exon junction complex (EJC) that is deposited at splice junctions on mRNAs, as a consequence of pre-mRNA splicing. It may thus be involved in mRNA metabolism associated with splicing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Synonyms

ACIN1; apoptotic chromatin condensation inducer 1; ACINUS, apoptotic chromatin condensation inducer in the nucleus; apoptotic chromatin condensation inducer in the nucleus; fSAP152; functional spliceosome associated protein 152; KIAA0670; ACIN 1; ACINUS; ACN; DKFZp667N107; OTTHUMP00000164548; OTTHUMP00000164549; OTTHUMP00000164550; OTTHUMP00000164551; OTTHUMP00000246163; OTTHUMP00000246164; functional spliceosome-associated protein 152