Background
This gene encodes a 42.3 kD subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size;from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in a diverse array of;cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle;formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like ACTR1A, is an actin-related;protein. These two proteins, which are of equal length and share 90% amino acid identity, are present in a constant;ratio of approximately 1:15 in the dynactin complex.