Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at BIO-Europe Spring|March 18–20, 2024|Booth #34

Ache

  • Official Full Name

    acetylcholinesterase (Yt blood group)

  • Overview

    Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally.
  • Synonyms

    ACHE; acetylcholinesterase (Yt blood group); YT; ACEE; ARACHE; N-ACHE;

  • Recombinant Proteins
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Cell & Tissue Lysates
  • Assay Kits
  • Bovine
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • Human Cell
  • Human Erythrocyte
  • In Vitro Cell Free System
  • Mamanlian cells
  • Mammalian Cell
  • Trichoplusia Ni Larval
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ACHE-105H Active Recombinant Human ACHE protein, His-tagged HEK293 His Glu 32 - Leu 614
Human ACHE-156H Recombinant Human ACHE Protein, GST-Tagged Wheat Germ GST
Human ACHE-130H Recombinant Human ACHE Mammalian Cell His
Human ACHE-106H Recombinant Human ACHE protein, MYC/DDK-tagged HEK293 Myc/DDK
Human ACHE-9289H Recombinant Human ACHE, GST-tagged E.coli GST 1-351a.a.
Human ACHE-101H Recombinant Human ACHE, His-tagged E.coli His 1-351aa
Human ACHE-09H Recombinant Human ACHE, His-tagged Trichoplusia Ni Larval His
Human ACHE-0578H Recombinant Human ACHE Protein (Phe377-Thr574), N-His-tagged E.coli N-His Phe377-Thr574
Human ACHE-04H Active Recombinant Human ACHE Protein, His-tagged HEK293 His 32-614aa
Human ACHE-1175H Recombinant Human ACHE Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ACHE-8345H Native Human ACHE Human Erythrocyte N/A
Human ACHE-0577H Recombinant Human ACHE Protein (Full Length), N-His-tagged E.coli N-His Full Length
Human ACHE-3333HFL Recombinant Full Length Human ACHE protein, Flag-tagged Mamanlian cells Flag
Human ACHE-778HF Recombinant Full Length Human ACHE Protein, GST-tagged In Vitro Cell Free System GST 640 amino acids
Human ACHE-2415H Recombinant Human ACHE Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ACHE-2415H-B Recombinant Human ACHE Protein Pre-coupled Magnetic Beads HEK293
Mouse Ache-07M Recombinant Mouse Ache, His-tagged Trichoplusia Ni Larval His
Mouse Ache-774M Active Recombinant Mouse Ache protein, His-tagged HEK293 His Glu 32 - Leu 614
Mouse Ache-08M Recombinant Mouse Ache Trichoplusia Ni Larval N/A
Mouse AchE-3060M Recombinant Mouse AchE, His-tagged E.coli His 614
Mouse ACHE-2163MCL Recombinant Mouse ACHE cell lysate Human Cell N/A
Mouse Ache-511M Recombinant Mouse Ache Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat Ache-6972R Recombinant Rat Ache protein, His-tagged E.coli His Gly366~Gly554 (Accession # P37136)
Rat Ache-6971R Recombinant Rat Ache protein, His-tagged E.coli His Gly157~Pro332 (Accession # P37136)
Rat ACHE-450R Recombinant Rat ACHE Protein Mammalian Cell His
Rat ACHE-106R-B Recombinant Rat ACHE Protein Pre-coupled Magnetic Beads HEK293
Rat ACHE-106R Recombinant Rat ACHE Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Bovine ACHE-3059B Recombinant Bovine ACHE, gst-tagged E.Coli or Yeast GST 613
Bovine ACHE-2476B Recombinant Bovine ACHE protein, GST-tagged E.coli GST 31-613aa
Rhesus Macaque ACHE-208R Recombinant Rhesus monkey ACHE Protein, His-tagged Mammalian Cell His
Rhesus Macaque ACHE-36R-B Recombinant Rhesus Macaque ACHE Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque ACHE-36R Recombinant Rhesus Macaque ACHE Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish ACHE-9352Z Recombinant Zebrafish ACHE Mammalian Cell His
Chicken ACHE-6969C Recombinant Chicken ACHE Mammalian Cell His
Kit-0035 Acetylcholinesterase Fluorometric Detection Kit N/A
Kit-0034 Acetylcholinesterase Red Fluorescence Assay Kit N/A
Kit-0031 Acetylcholinesterase Activity Colorimetric Assay Kit N/A
Kit-0032 Acetylcholinesterase Assay Kit N/A
Kit-0033 Acetylcholinesterase Green Fluorescence Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Ache Related Articles

Ache involved in several pathways and played different roles in them. We selected most pathways Ache participated on our site, such as Glycerophospholipid metabolism, Cholinergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ache were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Glycerophospholipid metabolismAGPAT5;PPAP2C;GPAM;CRLS1;ETNK1;LYPLA1;ACHE;PCYT1AB;CHPT1
Cholinergic synapseGNAO1;KCNQ3;CREB3L2;KCNQ5;MAPK3;GNB2;AKR1C1;GNG8;KRAS

Ache has several biochemical functions, for example, acetylcholine binding, acetylcholinesterase activity, beta-amyloid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Ache itself. We selected most functions Ache had, and list some proteins which have the same functions with Ache. You can find most of the proteins on our site.

Function Related Protein
acetylcholine bindingCHRNA3;CHRNB3;CHRFAM7A;CHRNB2;ACHE;CHRM3;CHRNB1;CHRNA4;CHRNA7
acetylcholinesterase activityBCHE;ACHE
beta-amyloid bindingBACE1;TSSK1B;FBXO2;APBA3;BACE2;HSD17B10;APBA2;MAPK8IP2;GPRASP2
cholinesterase activityCHKA;BCHE;CEL.1;CELL;ACHE
collagen bindingLUM;ITGA1;CCBE1;DDR1;ITGA10;ITGA3;VWF;PODN;CHADL
hydrolase activityEXOSC9;Ces2e;GPN3;MEP1A.1;PPAPDC3;PRSS59.1;PPP4CB;EHD2;INPPL1B
laminin bindingTINAGL1;LRRC15;LYPD3;ITGB1;LGALS3;ITGA7;ITGA9;LGALS1;PLEKHA2
protein bindingSNCA;HRASLS5;MZB1;FREM2;DHX40;TXNIP;VIL1;USP22;NCK1
protein homodimerization activityLILRB1;GRM6;GSTM7;Anks6;PDCD6IP;Pdgfa&Pdgfb;DAPK3;TWIST1;NLGN4X
protein self-associationNKX3-1;NKX3;CCL5;ZKSCAN17;SHANK3;EPB49;ZNF496;ZFP639;CTSC
serine hydrolase activityACHE;CELA2A;AADAC

Ache has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ache here. Most of them are supplied by our site. Hope this information will be useful for your research of Ache.

COLQ; ENO1; GNB2L1; acetylcholine; 2-phospho-d-glyceric acid; 3se1_denan; acetyl-beta-methyl-thiocholine; neostigmine; Eno1; ATF7; Gnb2l1

Carod-Artal, FJ; et al. Illness due the Ebola virus: epidemiology and clinical manifestations within the context of an international public health emergency. REVISTA DE NEUROLOGIA 60:267-277(2015).
Verma, N; Bhardwaj, A; et al. Biosensor Technology for Pesticides-A review. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY 175:3093-3119(2015).
  • Q&As
  • Reviews

Q&As (8)

Ask a question
When can I receive the product after ordering? 02/08/2023

The time required for different proteins varies, you can pay attention to the information on the product details page, or contact our experts directly.

Can ACHE-3333HFL products change tags? 12/02/2022

Sure. We can customize proteins according to customer needs, including different tags, expression system, protein length, etc.

Why the protein length of ACHE-101H product is 1-351aa? 11/19/2022

Because we can customize proteins of different lengths according to customer needs, please contact us if you are interested in this product.

What is the mechanism by which patients with Alzheimer's disease are treated with acetylcholinesterase inhibitors? 04/26/2022

Patients with Alzheimer disease often receive treatment with acetylcholinesterase inhibitors that mitigate symptoms by hindering ACh turnover.

In which tissues is acetylcholinesterase mainly distributed? 04/14/2021

Acetylcholinesterase is known to be distributed in nervous tissue such as the brainstem, cerebellum, and peripheral and autonomic nervous systems. Skeletal muscle also contains AChE with distribution patterns seemingly related to the type of muscle (fast versus slow twitch) and their specific function. AChE is also present on red blood cell membranes.

Does ACHE only work on terminating neurotransmission? 03/16/2021

Although the primary function of AChE is to terminate neural transmission, investigators have found that AChE also plays a role in neural development. During fetal development, AChE contributes to morphogenesis in addition to its main enzymatic function.

What form does acetylcholinesterase usually exist in? 07/29/2020

Acetylcholinesterase exists as a monomer that often polymerizes into a dimer with a disulfide bond. Along with Van der Waals forces, two dimers may be linked to become tetramers.

What is the role of ACHE? 02/04/2020

The primary role of AChE is to terminate neuronal transmission and signaling between synapses to prevent ACh dispersal and activation of nearby receptors. They are an important component of pesticides and nerve agents.

Customer Reviews (2)

Write a review
Reviews
12/12/2020

    I have already recommended creative biomart products to many colleagues.

    05/09/2019

      Received the product very quickly after placing the order, I am very satisfied.

      Ask a Question for All Ache Products

      Required fields are marked with *

      My Review for All Ache Products

      Required fields are marked with *

      logo

      FOLLOW US

      Terms and Conditions        Privacy Policy

      Copyright © 2024 Creative BioMart. All Rights Reserved.

      Contact Us

      • /

      Stay Updated on the Latest Bioscience Trends