Ache
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Official Full Name
acetylcholinesterase (Yt blood group)
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Overview
Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. -
Synonyms
ACHE; acetylcholinesterase (Yt blood group); YT; ACEE; ARACHE; N-ACHE;
- Recombinant Proteins
- Native Proteins
- Protein Pre-coupled Magnetic Beads
- Cell & Tissue Lysates
- Assay Kits
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- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
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- E.coli
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- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- MYC
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- Ache Related Articles
Ache involved in several pathways and played different roles in them. We selected most pathways Ache participated on our site, such as Glycerophospholipid metabolism, Cholinergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ache were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Glycerophospholipid metabolism | AGPAT5;AGPAT6;PCYT2;AGPAT3;PLA2G12B;DGKB;CHKA;CEPT1;DGKA |
Cholinergic synapse | GNGT2;KCNJ4;KCNQ5;PRKCA;GNB3;PIK3R1;CAMK2G;CAMK2D;PRKACB |
Ache has several biochemical functions, for example, acetylcholine binding, acetylcholinesterase activity, beta-amyloid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Ache itself. We selected most functions Ache had, and list some proteins which have the same functions with Ache. You can find most of the proteins on our site.
Function | Related Protein |
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acetylcholine binding | CHRNA4;CHRM3;CHRNA7;ACHE;CHRNB2;CHRNA3;CHRNB3;CHRNB1;CHRFAM7A |
acetylcholinesterase activity | ACHE;BCHE |
beta-amyloid binding | HSD17B10;MAPK8IP2;ITM2C;ARMCX5-GPRASP2;GPRASP2;APOE;BACE1;APOA1;OLFM1 |
cholinesterase activity | ACHE;BCHE;CHKA;CELL;CEL.1 |
collagen binding | ITGA10;ASPN;Itga10&Itgb1;FN1;LUM;TLL1;PAK1;DDR1;PCOLCE2 |
hydrolase activity | CTSSB.1;MBLAC2;PPEF2;FAM105B;GZMF;DDX39;BPGM;HDAC7;OTUB1B |
laminin binding | THBS1;BCAM;LYPD5;ACHE;LRRC15;ITGA9;LYPD3;ITGB1;AGRN |
protein binding | H2-AA;TRMT12;SIL1;OLFM2;DACT2;PSRC1;MON1B;CTSL1;PAAF1 |
protein homodimerization activity | GCA;FZD1;TRIM37;CBS;LILRB1;RBM11;LGALS1;KIAA1804;SNX9 |
protein self-association | TTN;CTSC;SLC2A1;NKX3-1;AGA;ACHE;PCSK9;BCL10;DYRK1A |
serine hydrolase activity | CELA2A;AADAC;ACHE |
Ache has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ache here. Most of them are supplied by our site. Hope this information will be useful for your research of Ache.
COLQ; ENO1; GNB2L1; acetylcholine; 2-phospho-d-glyceric acid; 3se1_denan; acetyl-beta-methyl-thiocholine; neostigmine; Eno1; ATF7; Gnb2l1
- Q&As
- Reviews
Q&As (8)
Ask a questionThe time required for different proteins varies, you can pay attention to the information on the product details page, or contact our experts directly.
Sure. We can customize proteins according to customer needs, including different tags, expression system, protein length, etc.
Because we can customize proteins of different lengths according to customer needs, please contact us if you are interested in this product.
Patients with Alzheimer disease often receive treatment with acetylcholinesterase inhibitors that mitigate symptoms by hindering ACh turnover.
Acetylcholinesterase is known to be distributed in nervous tissue such as the brainstem, cerebellum, and peripheral and autonomic nervous systems. Skeletal muscle also contains AChE with distribution patterns seemingly related to the type of muscle (fast versus slow twitch) and their specific function. AChE is also present on red blood cell membranes.
Although the primary function of AChE is to terminate neural transmission, investigators have found that AChE also plays a role in neural development. During fetal development, AChE contributes to morphogenesis in addition to its main enzymatic function.
Acetylcholinesterase exists as a monomer that often polymerizes into a dimer with a disulfide bond. Along with Van der Waals forces, two dimers may be linked to become tetramers.
The primary role of AChE is to terminate neuronal transmission and signaling between synapses to prevent ACh dispersal and activation of nearby receptors. They are an important component of pesticides and nerve agents.
Customer Reviews (2)
Write a reviewI have already recommended creative biomart products to many colleagues.
Received the product very quickly after placing the order, I am very satisfied.
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