Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate;mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A,;-1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns;of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four;transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding;properties.