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ALK

  • Official Full Name

    anaplastic lymphoma receptor tyrosine kinase

  • Overview

    This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).
  • Synonyms

    Alk; ALK tyrosine kinase receptor; ALK Tyrosine Kinase Receptor Precursor; ALK/EML4 fusion gene, included; ALK/NPM1 fusion gene, included; ALK_HUMAN; anaplastic lymphoma kinase (Ki-1); Anaplastic lymphoma kinase; Anaplastic lymphoma kinase Ki1; Anaplastic Lymphoma Kinase p80; CD246; CD246 Antigen; EC 2.7.10.1; Ki 1; Ki1; NBLST3; Tcrz; TFG/ALK;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Macaca nemestrina
  • Mouse
  • Rhesus monkey
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • Insect cell
  • Insect Cell
  • Mamanlian cells
  • Mammalian Cell
  • Mammalian cells
  • Sf21 Insect Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • C
  • His
  • DDK|His
  • Flag
  • GST
  • GST|His
  • hIgG1
  • hIgG4
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ALK-08H Active Recombinant Human ALK, GST-tagged Sf21 Insect Cell GST
Human ALK-92H Active Recombinant Human ALK, GST-His Tag Sf9 Insect Cell GST/His
Human ALK-469H Active Recombinant Human ALK Protein, GST-tagged Insect Cell GST
Human ALK-471H Active Recombinant Human ALK Protein, GST-His tagged Insect Cell GST/His
Human ALK-58H Recombinant Human ALK (C1156Y), GST-tagged Sf9 Insect Cell GST
Human ALK-15H Recombinant Human ALK (S1206R), GST-tagged Sf9 Insect Cell GST
Human ALK-10H Recombinant Human ALK, His-tagged Sf9 Insect Cell His
Human ALK-473H Recombinant Human ALK Protein, GST-tagged Wheat Germ GST
Human ALK-28H Recombinant Human ALK (F1174L), GST-tagged Sf9 Insect Cell GST
Human ALK-27H Recombinant Human ALK (T1151_L1152insT), GST-tagged Sf9 Insect Cell GST
Human ALK-26499TH Recombinant Human ALK E.coli N/A
Human ALK-30H Recombinant Human ALK (G1269S), GST-tagged Sf9 Insect Cell GST
Human ALK-13H Recombinant Human ALK (F1174S), GST-tagged Sf9 Insect Cell GST
Human ALK-49H Recombinant Human ALK (T1151M), GST-tagged Sf9 Insect Cell GST
Human ALK-01H Active Recombinant Human ALK Protein, GST-tagged Insect Cell GST
Human ALK-50H Recombinant Human ALK (L1152R), GST-tagged Sf9 Insect Cell GST
Human ALK-29H Recombinant Human ALK (G1202R), GST-tagged Sf9 Insect Cell GST
Human ALK-31H Recombinant Human ALK (R1275Q), GST-tagged Sf9 Insect Cell GST
Human ALK-51H Recombinant Human ALK (G1269A), GST-tagged Sf9 Insect Cell GST
Human ALK-12H Recombinant Human ALK, GST-tagged Sf9 Insect Cell GST
Human ALK-09H Active Recombinant Human ALK, MYC/DDK-tagged HEK293 Myc/DDK
Human ALK-89H Recombinant Human ALK, His Tag Sf9 Insect Cell His
Human ALK-14H Recombinant Human ALK (L1196M), GST-tagged Sf9 Insect Cell GST
Human ALK-33H Recombinant Human ALK(L1196M) protein, Flag-tagged, Biotinylated Insect Cell Flag
Human ALK-65H Recombinant Human Anaplastic Lymphoma Receptor Tyrosine Kinase E.coli N/A
Human ALK-32H Recombinant Human ALK protein, Flag-tagged, Biotinylated Insect Cell Flag
Human ALK-385H Recombinant Human ALK Protein, DDK/His-tagged HEK293 DDK/His
Human ALK-2573H Recombinant Human ALK protein, His-tagged E.coli His 43-366 aa
Human ALK-1272H Recombinant Human ALK Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ALK-1801HFL Recombinant Full Length Human ALK, Flag-tagged Mamanlian cells Flag
Human ALK-26H Recombinant Human ALK protein, His-tagged E.coli His Met1348-Ser1611
Human ALK-318H-B Recombinant Human ALK Protein Pre-coupled Magnetic Beads HEK293
Human ALK-02H Recombinant Human ALK (L1196M G1202R) Protein, GST-tagged Insect cell GST
Human ALK-318H Recombinant Human ALK Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ALK-3120H Recombinant Human ALK protein, His-tagged E.coli His 1400-1620 aa
Human ALK18290H Recombinant Human ALK (1081-1419) Protein, GST-tagged Insect Cell GST
Human ALK-1151HFL Recombinant Full Length Human ALK Protein, C-Flag-tagged Mammalian cells Flag
Human ALK25121H Recombinant Human ALK (1069-1396) Protein, GST-tagged Insect Cell GST
Human ALK1430H Recombinant Human ALK (1081-1411) Protein, GST-tagged Insect Cell GST
Human ALK1343H Recombinant Human ALK (1069-1411) Protein, GST-tagged Insect Cell GST
Human ALK-4163H Recombinant Human ALK Protein (Met1-Ser1038), C-His tagged Mammalian cells C-His Met1-Ser1038
Mouse ALK-1552M Recombinant Mouse ALK Protein Mammalian Cell His
Mouse Alk-3270M Recombinant Mouse Alk, His-tagged E.Coli or Yeast His 1621
Mouse Alk-15M Recombinant Mouse Alk Protein HEK293 N/A aa.19-1042
Mouse Alk-577M Recombinant Mouse Alk Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse ALK-472M-B Recombinant Mouse ALK Protein Pre-coupled Magnetic Beads HEK293
Mouse ALK-472M Recombinant Mouse ALK Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus monkey ALK-1626R Recombinant Rhesus Monkey ALK Protein, hIgG1-tagged HEK293 hIgG1
Rhesus monkey ALK-1625R Recombinant Rhesus Monkey ALK Protein HEK293 N/A
Rhesus monkey ALK-1627R Recombinant Rhesus Monkey ALK Protein, hIgG4-tagged HEK293 hIgG4
Macaca nemestrina ALK-16M Recombinant Macaca nemestrina ALK Protein HEK293 N/A aa.19-1038
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ALK Related Articles

ALK involved in several pathways and played different roles in them. We selected most pathways ALK participated on our site, such as Non-small cell lung cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Non-small cell lung cancerPDPK1;MAPK1;MAP2K1;RARB;HRAS;CASP9;MAPK3;PIK3CA;PIK3R1

ALK has several biochemical functions, for example, ATP binding, NF-kappaB-inducing kinase activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ALK itself. We selected most functions ALK had, and list some proteins which have the same functions with ALK. You can find most of the proteins on our site.

Function Related Protein
ATP bindingCKMT2;ATP2B1B;BLK;FLT4;MAPK12;DCLK3;PRKD1;ABCA5;GRK5
NF-kappaB-inducing kinase activityIKBKE;RIPK3;MAP3K14;PPP4C;ALPK2;IRAK1;ALK
identical protein bindingIMPA1;SMURF2;CALCA;PSMA7;CBX3;TGFB3;PHYKPL;ZNF212;MAP3K13
protein bindingSYNCRIP;HSF1;ST13;HPCAL1;GPN1;RASAL2;THAP6;UCP3;IL-8
protein tyrosine kinase activityPTK7A;PTK2BB;PTK2B;ABL1;EPHA4A;MATK;TTK;PTK7;AXL
transmembrane receptor protein tyrosine kinase activityNTRK1;INSRA;EGFR;EPHB4;FGFR1A;TRIM27;DDR1;ERBB3A;DDR2

ALK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALK here. Most of them are supplied by our site. Hope this information will be useful for your research of ALK.

crizotinib; ch5424802; PTPRZ1; HSP90AB1; EPHA1; EIF4B

Ziegler, JU; Schweiggert, RM; et al. A method for the simultaneous extraction and quantitation of lipophilic antioxidants in Triticum sp by HPLC-DAD/FLD-MSn. JOURNAL OF FOOD COMPOSITION AND ANALYSIS 39:94-102(2015).
Ishibashi, Y; Miyoshi, H; et al. Anaplastic lymphoma kinase protein expression, genetic abnormalities, and phosphorylation in soft tissue tumors: Phosphorylation is associated with recurrent metastasis. ONCOLOGY REPORTS 33:1667-1674(2015).
  • Q&As
  • Reviews

Q&As (17)

Ask a question
How do common mutations of ALK and other genes affect the prognosis of lung cancer? 01/11/2023

The common mutation of ALK and other genes may affect the prognosis and therapeutic effect of lung cancer, and provide new ideas for individualized treatment.

How does the phosphorylation process of ALK affect its activity? 12/06/2022

Phosphorylation of ALK can affect its activity and signal transmission efficiency, which has an impact on the biological process of cells.

What is the application prospect of ALK in breast cancer treatment? 08/06/2022

The application prospect of ALK in the treatment of breast cancer needs to be further studied and discussed, and the expression level in breast cancer cells is not clear.

What is the interaction of ALK with other tumor suppressor genes? 12/23/2021

The interaction between ALK and other tumor suppressor genes may affect the occurrence and development of tumors, and provide new ideas for tumor treatment.

What role does ALK play in lung cancer signaling pathways? 08/06/2021

This is involved in a variety of lung cancer signaling pathways, such as PI3K/Akt, MAPK/ERK, STAT3 and other pathways.

What diseases is ALK associated with? 04/29/2021

It is associated with lung cancer, thyroid cancer, lymphoma and neuroblastoma.

Which pathway of ALK as a targeted drug? 02/12/2021

As a targeted drug, ALK is mainly used by oral administration and intravenous injection, which can help in the treatment of diseases such as lung cancer.

What is the expression of ALK in lung cancer? 01/05/2021

ALK is overexpressed in a small number of lung cancer patients and is involved in the occurrence and development of lung cancer.

How does ALK mutation affect the prognosis of lung cancer? 12/03/2020

The mutation may affect the prognosis and therapeutic effect of lung cancer, suggesting the importance of ALK targeted therapy.

How the role of ALK in nervous system tumors? 09/05/2020

ALK is involved in signal transduction and cell growth in nervous system tumors, and has a certain influence on the occurrence and development of nervous system tumors.

In what physiological processes does ALK play a role? 07/04/2020

ALK plays an important role in many physiological processes such as neuron migration, embryonic development and osteoblast differentiation.

Can ALK be used as a screening indicator for lung cancer? 06/27/2020

ALK can be used as one of the screening indicators for lung cancer, which can help the early diagnosis and treatment of lung cancer.

In which cell types is ALK expressed? 06/15/2020

ALK is expressed in a variety of cell types such as the nervous system, lymphatic system, and immune system, and is involved in a variety of biological processes.

What are the regulatory mechanisms of ALK? 11/05/2019

The regulatory mechanisms of ALK mainly include gene mutation, gene expression regulation, quality control and signal pathway regulation.

Does the prognostic impact of ALK targeted therapy on lung cancer? 11/04/2019

The effect of ALK targeted therapy on the prognosis of lung cancer may be related to a variety of factors, including tumor stage, pathological type, treatment regimen, etc.

What is the role of ALK in the treatment of lung cancer? 10/12/2019

ALK can be used as an important marker of targeted therapy in the treatment of lung cancer, providing an individualized treatment strategy.

Whether there is the relationship between ALK and colorectal cancer? 06/17/2019

The relationship between ALK and colorectal cancer is unclear and needs further study.

Customer Reviews (4)

Write a review
Reviews
07/05/2021

    ALK has strict quality control and complies with relevant industry standards.

    02/11/2021

      The yield of ALK is high and has good economic benefits.

      12/22/2020

        The enzymatic activity of ALK reached the expected level and was able to play a role in specific reactions.

        01/07/2019

          Stable and reproducible results can be obtained when experiments are performed using ALK.

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