ap1b1
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  • Official Full Name
  • adaptor-related protein complex 1, beta 1 subunit
  • Background
  • Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as one of the large subunits of this complex and is a member of the adaptin protein family. This gene is a candidate meningioma gene. Alternative splicing results in multiple transcript variants.
  • Synonyms
  • AP1B1; adaptor-related protein complex 1, beta 1 subunit; ADTB1, CLAPB2; AP-1 complex subunit beta-1; AP105A; BAM22; beta1-adaptin; beta-1-adaptin; beta-adaptin 1; beta-prime-adaptin; Golgi adaptor HA1/AP1 adaptin beta subunit; adaptor protein complex AP-
Cat.#:AP1B1-644HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human AP1B1 protein, GST-tagged
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Cat.#:AP1B1-9707HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AP1B1, His-tagged
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Cat.#:Ap1b1-3523RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat Ap1b1, His-tagged
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Cat.#:AP1B1-698RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat AP1B1 Protein
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Cat.#:AP1B1-6919ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish AP1B1
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Involved Pathway

AP1B1 involved in several pathways and played different roles in them. We selected most pathways AP1B1 participated on our site, such as Adaptive Immune System, Clathrin derived vesicle budding, Disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with AP1B1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adaptive Immune System
SIGLEC6; SEC61B; LILRA1; CXADR; RACGAP1; RNF4; CSK; DYNLL2; FGF8B; KIF22
Clathrin derived vesicle budding
CTSZ; AP1B1; DNM2; AP1S1; PICALMB; DTNBP1; AP1S3A; HIP1RB; DNASE2; TPD52
Disease
RBP1; RCC1; NPM1; IPO5; CHMP4B; MYO18A; DERL2; CPSF6; VPS37A; NMT1
FOXA1 transcription factor network
CYP2C18; TFF1; CC10; NFIC; NRIP1; NFIA; FOXA1; POU2F1; NR2F2; DSCAM
Golgi Associated Vesicle Biogenesis
CLINT1; SNAPIN; TGOLN2; BLOC1S6; TPD52; AP1M2; GAK; AP1B1; NAPAB; SNX9A
HIV Infection
PSIP1; ELL; AP1S1; TCEB3; AP1B1; DOCK2; AP1G1; NMT1; PDCD6IP; VPS37A
Host Interactions of HIV factors
RCC1; PSIP1; DOCK2; PACS1; AP1G1; AP1B1; APOBEC3G; PPIAL4A; AP1M2; AP1S1
Immune System
BTR30; FBXO44; UBE2U; KIR2DS2; ADAR; TREML4; TRIM22; ASB17; CYBB; CLEC2G

Protein Function

AP1B1 has several biochemical functions, for example, protein binding, protein kinase binding, protein transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AP1B1 itself. We selected most functions AP1B1 had, and list some proteins which have the same functions with AP1B1. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein CLIC3; SH3BP1; PSMD3; RWDD1; KDM1A; FUNDC1; RSPH1; Trl; KCND2; GOLGA8G
Function protein kinase binding
Related Protein TRIM5; MAP3K2; CSPG4; CDK5; RACGAP1; CHEK2; DNAJA3; PXN; NPR1; CEP152
Function protein transporter activity
Related Protein TNPO3; AP3S1; FRAG1; AP3S2; IPO8; AP4B1; KPNA2; KPNB3; KPNA4; L7RN6
Function transporter activity
Related Protein CRABP2B; HIATL2; SLC4A1A; SLC22A13; LCN12; CPNE7; TTPAL; FABP5; AP4B1; CHP

Interacting Protein

AP1B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AP1B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AP1B1.
Ap1g1; Ap1m1; nef; AP1S1; AP1S3; 1-phosphatidyl-1d-myo-inositol 3,4,5-trisphosphate

AP1B1 Related Articles

Saito, T; Ji, G; et al. Genetic variations in humans associated with differences in the course of hepatitis C. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 317:335-341(2004).