FAS
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Official Full Name
Fas cell surface death receptor
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Overview
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. -
Synonyms
FAS; Fas cell surface death receptor; APT1; CD95; FAS1; APO-1; FASTM; ALPS1A; TNFRSF6;
- Recombinant Proteins
- Cell & Tissue Lysates
- Others
- Protein Pre-coupled Magnetic Beads
- Bos taurus (Bovine)
- Cattle
- Chicken
- Cynomolgus
- Cynomolgus Monkey
- Feline
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Pig
- Rat
- Rhesus Macaque
- Sus scrofa (Pig)
- E.coli
- E.coli expression system
- HEK293
- HEK293F
- HEK293T
- Human
- Human Cell
- Human cells
- Human Cells
- Human Embryo Kidney
- In Vitro Cell Free System
- In vitro E. coli expression system
- Mamanlian cells
- Mammalian Cell
- Mammalian cells
- Sf21 Insect Cell
- Wheat Germ
- C
- Fc
- His
- Fc Chimera
- His(C
- ter)
- Flag
- GST
- hFc
- His (Fc)
- Avi
- His|Flag|StrepII
- His|GST
- His|MBP
- His|T7
- human|IgG1|Fc
- Myc
- DDK
- MYC
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- FAS Related Articles
- FAS Related Research Area
- FAS Related Signal Pathway
FAS involved in several pathways and played different roles in them. We selected most pathways FAS participated on our site, such as MAPK signaling pathway, Cytokine-cytokine receptor interaction, p signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FAS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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MAPK signaling pathway | PDGFRB;RRAS2;MAPK9;MKNK2;TNFRSF1A;GADD45AB;IL1B;HSPB1;CACNA1C |
Cytokine-cytokine receptor interaction | IFNAR1;VEGFC;PDGFB;CXCR1;IL21R;IL26;CXCL5;IL28A;GM10591 |
p signaling pathway | CYCS;PTEN;RPRM;CD82B;GADD45AA;FAS;RRM2;CCND1;TP53 |
Apoptosis | CDKN2A;IRAK3;H1F0;AKT2;HIST1H1D;CDK5RAP2;PRKACBA;CTNNB1;APAF1 |
Natural killer cell mediated cytotoxicity | CD244;KIR2DS3;MICB;RAET1G;GZMB;KIR3DL2;MAPK3;HLA-B;TNFRSF10A |
TNF signaling pathway | PIK3R1;DNM1L;TNFAIP3;CCL5;MMP9;MMP14;CFLAR;TRAF3;MAPK1 |
Non-alcoholic fatty liver disease (NAFLD) | PRKAG2;CYCS;INS1;IL1B;UQCRC2;COX6B2;COX7B2;IRS1;COX4I2 |
Type I diabetes mellitus | INS1;H2-AB1;HLA-F;PTPRN2;CD28;HLA-DRB1;INS2;HLA-C;TNF |
Alzheimers disease | PLCB1;LPL;Casp3;CALM2;COX7A1;GRIN1;ATP2A3;ADAM10;CHP |
Chagas disease (American trypanosomiasis) | IL6;MYD88;TLR2;PIK3CG;PLCB3;IFNB1;CCL2;SMAD2;PPP2R1A |
African trypanosomiasis | MYD88;HBB-B2;PRKCA;PRKCB;HPR;IL18;PLCB1;HBB-B1;PLCB4 |
Hepatitis B | SRC;PCNA;STAT2;IL-8;APAF1;GRB2;HRAS;STAT1;STAT6 |
Measles | PIK3CA;IFIH1;SH2D1A;EIF2AK3;TP73;IRF7;AKT2;CD209C;CD209A |
Influenza A | TNFRSF10D;TNFRSF10A;HSPA8;IL6;IRF7;HSPA2;Ifna15;PML;EIF2AK1 |
Herpes simplex infection | CDC34;DAXX;SFRS9;BLB1;PER3;SRSF5A;EP300;NFKBIB;PTPN11A |
Pathways in cancer | MAPK9;PGF;FGFR1;TPM3;F2RL3;ABL1;PIK3CD;FZD3;LAMB3 |
Proteoglycans in cancer | MSN;CTTN;HPSE;PTK2;PTPN11;EZR;ERBB3;RPS6;IGF1 |
Autoi | H2-AB1;GZMB;IFNA6;CD80;TPO;HLA-DMA;Il2;H2-AA;HLA-C |
ne thyroid disease | IL5;HLA-DOB;IFNA21;IFNA13;HLA-G;HLA-DRB3;Ifna15;IFNA7;IFNA14 |
Allograft rejection | HLA-DOB;PRF1;IL4;IL12B;H2-AA;CD80;HLA-DQA2;HLA-DQB1;HLA-DRB5 |
Graft-versus-host disease | H2-AB1;HLA-DRB4;H2-Q10;HLA-DRA;CD28;HLA-DPB1;CD80;HLA-DRB1;HLA-DQA2 |
FAS has several biochemical functions, for example, identical protein binding, kinase binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FAS itself. We selected most functions FAS had, and list some proteins which have the same functions with FAS. You can find most of the proteins on our site.
Function | Related Protein |
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identical protein binding | CDC42;NME1;BRAF;APPL1;ST13;FXR2;GRIK5;BCAT1;ANXA4 |
kinase binding | TRIP6;MIDN;DLG4;ABI2;SNAI1;PRKCD;PFKFB1;CAB39;SP100 |
protein binding | FNBP4;NXF1;VPS4B;TTC6;MAFB;PABPC1;MTDH;STX11;SPTSSA |
receptor activity | TRAM1;TMEM123;CCR6;ADIPOR1A;OGFRL1;KIR2DL1;OGFRL2;PAQR3B;TNFRSF25 |
signal transducer activity | PTH1RA;PPP1R12A;OLFR470;LPAR6;PARAPINOPSINB;OLFR5;PLK2;PLCD4;ITGB3BP |
tumor necrosis factor-activated receptor activity | TNFRSF11A;Tnfrsf26;RELT;TNFRSF19;TNFRSF1A;HDR;TNFRSF6B;EDA2R;LTBR |
FAS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FAS here. Most of them are supplied by our site. Hope this information will be useful for your research of FAS.
FADD
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Q&As (6)
Ask a questionFAS protein plays an important role in cell signaling, it can activate downstream signaling pathways, such as death signaling pathway and survival signaling pathway, by binding to its ligand and transmitting signals.
It can provide a reference for clinical practice and guide the diagnosis, treatment and prevention of diseases by detecting the expression level of FAS protein and understanding its mechanism of action.
FAS protein-related diseases can be prevented and treated by regulating the expression level of FAS protein and inhibiting its signaling pathway.
Gene knockout or knockdown techniques can be used to study the function and mechanism of action of FAS proteins. By knocking out or knocking down the FAS gene, changes in processes such as apoptosis and immune response can be observed to further understand its function and mechanism of action.
FAS protein can bind to its ligand, activate the death signaling pathway, and induce apoptosis.
The expression level and activity of FAS protein can be measured to predict the prognosis and development trend of certain diseases.
Customer Reviews (3)
Write a reviewWhen experimenting with FAS, the results are very reproducible.
The stability of FAS products allows them to cope with different experimental conditions and modes of operation.
FAS has high specific activity and can exert strong biological effect at low concentration.
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