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FAS

  • Official Full Name

    Fas cell surface death receptor

  • Overview

    The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.
  • Synonyms

    FAS; Fas cell surface death receptor; APT1; CD95; FAS1; APO-1; FASTM; ALPS1A; TNFRSF6;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Others
  • Protein Pre-coupled Magnetic Beads
  • Bos taurus (Bovine)
  • Cattle
  • Chicken
  • Cynomolgus
  • Cynomolgus Monkey
  • Feline
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Pig
  • Rat
  • Rhesus Macaque
  • Sus scrofa (Pig)
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293F
  • HEK293T
  • Human
  • Human Cell
  • Human cells
  • Human Cells
  • Human Embryo Kidney
  • In Vitro Cell Free System
  • In vitro E. coli expression system
  • Mamanlian cells
  • Mammalian Cell
  • Mammalian cells
  • Sf21 Insect Cell
  • Wheat Germ
  • C
  • Fc
  • His
  • Fc Chimera
  • His(C
  • ter)
  • Flag
  • GST
  • hFc
  • His (Fc)
  • Avi
  • His|Flag|StrepII
  • His|GST
  • His|MBP
  • His|T7
  • human|IgG1|Fc
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FAS-519H Active Recombinant Human FAS E.coli N/A
Human FAS-603H Active Recombinant Human FAS, Fc-tagged, Biotinylated Human Cell Fc
Human FAS-281H Recombinant Human FAS, His & GST tagged Human Cell His/GST
Human FAS-1411H Recombinant Human Fas (TNF Receptor Ssuper Family, Member 6) Human Embryo Kidney N/A
Human FAS-614H Recombinant Human FAS protein, His-tagged E.coli His Gln26~Asn173 (Accession # P25445)
Human FAS-26332TH Recombinant Human FAS protein E.coli N/A 157
Human FAS-3154H Active Recombinant Human Fas protein, His-tagged HEK293 His Met1-Asn173
Human FAS-5411H Recombinant Human Fas (TNF receptor superfamily, member 6) E.coli N/A
Human FAS-616H Recombinant Human FAS protein, His & MBP-tagged E.coli His/MBP Ser22~Ser172 (Accession # P25445)
Human FAS-3814H Recombinant Human Fas (TNF receptor superfamily, member 6) Human N/A
Human FAS-27896TH Recombinant Human FAS, His-tagged E.coli His 164 amino acids
Human FAS-4270H Recombinant Human Fas (TNF Receptor Superfamily, Member 6) Human N/A
Human FAS-3850H Recombinant Human FAS Protein Wheat Germ N/A
Human FAS-1615H Recombinant Human Fas (TNF Receptor Superfamily, Member 6) Mammalian cells N/A
Human FAS-3853H Recombinant Human FAS Protein, GST-tagged Wheat Germ GST
Human FAS-37H Recombinant Human Fas Ligand Inhibitor, Fc-tagged Fc
Human FAS-5265H Recombinant Human Fas (TNF receptor superfamily, member 6) Human Embryo Kidney N/A
Human FAS-239H Active Recombinant Human FAS, Fc-tagged HEK293 Fc
Human FAS-602H Recombinant Human FAS protein, Fc-tagged HEK293 human/IgG1/Fc Gln26-Asn173
Human FAS-38H Recombinant Human Fas Ligand soluble, FLAG-tagged HEK293 Flag
Human FAS-12751H Recombinant Human FAS, GST-tagged E.coli GST C-term-180a.a.
Human FAS-16H Recombinant Human FAS protein, MYC/DDK-tagged HEK293 Myc/DDK
Human Fas-026H Active Recombinant Human Fas protein, Fc-tagged HEK293 Fc Gln26-Asn173
Human FAS-3851H Recombinant Human FAS Protein, His/Flag/StrepII-tagged Human cells His/Flag/StrepII
Human Fas-027H Recombinant Human Fas protein, His-tagged HEK293 His Gln26-Asn173
Human FAS-615H Recombinant Human FAS protein, His & GST-tagged E.coli His/GST Ser22~Ser172 (Accession # P25445)
Human FAS-2185HCL Recombinant Human FAS cell lysate Human Cell N/A
Human CDA093P Recombinant Human CD95 E.coli N/A
Human FAS-70H Recombinant Active Human FAS Protein (ECD), Fc-His-tagged(C-ter) HEK293 Fc-His(C-ter) Gln26-Asn173
Human FAS-4772HF Recombinant Full Length Human FAS Protein In Vitro Cell Free System 198 amino acids
Human FAS-4983H Recombinant Human FAS Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human FAS-151H Recombinant Human FAS Protein, His-tagged Human Cells His
Human FAS-2374H Recombinant Human FAS Full Length Transmembrane protein, His-tagged In vitro E. coli expression system His 26-335aa
Human FAS-2288H Recombinant Human FAS Protein (Gln26-Asn173), C-His tagged Mammalian cells C-His Gln26-Asn173
Human FAS-2893HFL Recombinant Full Length Human FAS protein, Flag-tagged Mamanlian cells Flag
Human FAS-4403H Recombinant Human FAS Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CDA074P Recombinant Human CD-95, His Tag E.coli N/A
Human FAS-242H Recombinant Human FAS Protein, His-tagged HEK293 His 335
Human FAS-4858HF Recombinant Full Length Human FAS Protein, GST-tagged In Vitro Cell Free System GST 335 amino acids
Human FAS-243H Recombinant Human FAS Protein, Fc-tagged HEK293 Fc 335
Human FAS-2664H Active Recombinant Human FAS protein, hFc&His-tagged HEK293 hFc&His Gln26-Asn173
Human FAS-4403H-B Recombinant Human FAS Protein Pre-coupled Magnetic Beads HEK293
Human FAS-2287H Recombinant Human FAS Protein (Gln26-Asn173), C-Fc tagged Mammalian cells C-Fc Gln26-Asn173
Human FAS-0713H Recombinant Human FAS Protein (Met1-Asn173), C-His tagged Mammalian cells C-His Met1-Asn173
Mouse Fas-618M Recombinant Mouse Fas protein, His-tagged E.coli His Lys188~Asn319 (Accession # P25446)
Mouse Fas-1735M Recombinant Mouse Fas (TNF Receptor Superfamily Member 6) Sf21 Insect Cell N/A
Mouse Fas-617M Recombinant Mouse Fas protein, His-tagged E.coli His Gln22~Arg169
Mouse Fas-3268M Active Recombinant Mouse Fas protein(Met1-Arg169), His-tagged HEK293 C-His Met1-Arg169
Mouse FAS-2419MCL Recombinant Mouse FAS cell lysate Human Cell N/A
Mouse Fas-5660M Recombinant Mouse Fas Protein (Gln22-Arg169), C-Fc tagged Mammalian cells C-Fc Gln22-Arg169
Mouse Fas-5661M Recombinant Mouse Fas Protein (Gln22-Arg169), C-His tagged Mammalian cells C-His Gln22-Arg169
Mouse Fas-1020M Recombinant Mouse Fas Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat Fas-823R Active Recombinant Rat Fas Protein, Fc Chimera Mammalian cells Fc
Rat FAS-2273R Recombinant Rat FAS Protein Mammalian Cell His
Rat Fas-4096R Active Recombinant Rat Fas protein, His-tagged HEK293 His Met1-Lys170
Rat Fas-620R Recombinant Rat Fas protein, His & GST-tagged E.coli His/GST Met21~Lys170 (Accession # Q63199)
Rat FAS-547R Recombinant Rat Fas, Fc tagged Human Cell Fc
Rat Fas-622R Recombinant Rat Fas protein, His & MBP-tagged E.coli His/MBP Met21~Lys170 (Accession # Q63199)
Rat Fas-486R Recombinant Rat Fas protein, His-tagged HEK293F His Gln22~Leu171
Rat FAS-1139RCL Recombinant Rat FAS cell lysate Human Cell N/A
Rat Fas-12R-B Recombinant Rat Fas Protein Pre-coupled Magnetic Beads HEK293
Rat Fas-12R Recombinant Rat Fas Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Bos taurus (Bovine) RFL539BF Recombinant Full Length Bovine Tumor Necrosis Factor Receptor Superfamily Member 6(Fas) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (23-323)
Cattle FAS-613C Recombinant Cattle FAS protein, His & T7-tagged E.coli His/T7 Leu37~Tyr274
Cattle FAS-921C Recombinant Cattle FAS Protein, His&GST-tagged E.coli N-His&GST Leu37-Tyr274
Cynomolgus FAS-2183C Active Recombinant Cynomolgus FAS protein, hFc-tagged HEK293 hFc Met1-Asp173
Cynomolgus Monkey FAS-142C Recombinant Cynomolgus FAS, Fc tagged Human Cell His/GST
Cynomolgus Monkey FAS-203C Recombinant Cynomolgus FAS Human Cell N/A Met1-Asp173
Cynomolgus Monkey FAS-513C Recombinant Cynomolgus FAS Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey FAS-001CCL Recombinant Cynomolgus FAS cell lysate Human Cell N/A
Cynomolgus Monkey FAS-258C Recombinant Cynomolgus Monkey FAS Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey FAS-258C-B Recombinant Cynomolgus Monkey FAS Protein Pre-coupled Magnetic Beads HEK293
Feline FAS-635F Active Recombinant Feline FAS, Fc Chimera Mammalian cells Fc Chimera
Feline FAS-2F Recombinant Feline FAS Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Feline FAS-2F-B Recombinant Feline FAS Protein Pre-coupled Magnetic Beads HEK293
Homo sapiens (Human) RFL6573HF Recombinant Full Length Human Tumor Necrosis Factor Receptor Superfamily Member 6(Fas) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (26-335aa)
Mus musculus (Mouse) RFL9899MF Recombinant Full Length Mouse Tumor Necrosis Factor Receptor Superfamily Member 6(Fas) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (22-327)
Rhesus Macaque FAS-1644R Recombinant Rhesus monkey FAS Protein, His-tagged Mammalian Cell His
Rhesus Macaque FAS-1468R-B Recombinant Rhesus Macaque FAS Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque FAS-1468R Recombinant Rhesus Macaque FAS Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Sus scrofa (Pig) RFL17912SF Recombinant Full Length Pig Tumor Necrosis Factor Receptor Superfamily Member 6(Fas) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (17-332)
Pig FAS-619P Recombinant Pig FAS protein, His & GST-tagged E.coli His/GST Glu48~Tyr281
Chicken FAS-4338C Recombinant Chicken FAS Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • FAS Related Articles
  • FAS Related Research Area
  • FAS Related Signal Pathway

FAS involved in several pathways and played different roles in them. We selected most pathways FAS participated on our site, such as MAPK signaling pathway, Cytokine-cytokine receptor interaction, p signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FAS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayPDGFRB;RRAS2;MAPK9;MKNK2;TNFRSF1A;GADD45AB;IL1B;HSPB1;CACNA1C
Cytokine-cytokine receptor interactionIFNAR1;VEGFC;PDGFB;CXCR1;IL21R;IL26;CXCL5;IL28A;GM10591
p signaling pathwayCYCS;PTEN;RPRM;CD82B;GADD45AA;FAS;RRM2;CCND1;TP53
ApoptosisCDKN2A;IRAK3;H1F0;AKT2;HIST1H1D;CDK5RAP2;PRKACBA;CTNNB1;APAF1
Natural killer cell mediated cytotoxicityCD244;KIR2DS3;MICB;RAET1G;GZMB;KIR3DL2;MAPK3;HLA-B;TNFRSF10A
TNF signaling pathwayPIK3R1;DNM1L;TNFAIP3;CCL5;MMP9;MMP14;CFLAR;TRAF3;MAPK1
Non-alcoholic fatty liver disease (NAFLD)PRKAG2;CYCS;INS1;IL1B;UQCRC2;COX6B2;COX7B2;IRS1;COX4I2
Type I diabetes mellitusINS1;H2-AB1;HLA-F;PTPRN2;CD28;HLA-DRB1;INS2;HLA-C;TNF
Alzheimers diseasePLCB1;LPL;Casp3;CALM2;COX7A1;GRIN1;ATP2A3;ADAM10;CHP
Chagas disease (American trypanosomiasis)IL6;MYD88;TLR2;PIK3CG;PLCB3;IFNB1;CCL2;SMAD2;PPP2R1A
African trypanosomiasisMYD88;HBB-B2;PRKCA;PRKCB;HPR;IL18;PLCB1;HBB-B1;PLCB4
Hepatitis BSRC;PCNA;STAT2;IL-8;APAF1;GRB2;HRAS;STAT1;STAT6
MeaslesPIK3CA;IFIH1;SH2D1A;EIF2AK3;TP73;IRF7;AKT2;CD209C;CD209A
Influenza ATNFRSF10D;TNFRSF10A;HSPA8;IL6;IRF7;HSPA2;Ifna15;PML;EIF2AK1
Herpes simplex infectionCDC34;DAXX;SFRS9;BLB1;PER3;SRSF5A;EP300;NFKBIB;PTPN11A
Pathways in cancerMAPK9;PGF;FGFR1;TPM3;F2RL3;ABL1;PIK3CD;FZD3;LAMB3
Proteoglycans in cancerMSN;CTTN;HPSE;PTK2;PTPN11;EZR;ERBB3;RPS6;IGF1
AutoiH2-AB1;GZMB;IFNA6;CD80;TPO;HLA-DMA;Il2;H2-AA;HLA-C
ne thyroid diseaseIL5;HLA-DOB;IFNA21;IFNA13;HLA-G;HLA-DRB3;Ifna15;IFNA7;IFNA14
Allograft rejectionHLA-DOB;PRF1;IL4;IL12B;H2-AA;CD80;HLA-DQA2;HLA-DQB1;HLA-DRB5
Graft-versus-host diseaseH2-AB1;HLA-DRB4;H2-Q10;HLA-DRA;CD28;HLA-DPB1;CD80;HLA-DRB1;HLA-DQA2

FAS has several biochemical functions, for example, identical protein binding, kinase binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FAS itself. We selected most functions FAS had, and list some proteins which have the same functions with FAS. You can find most of the proteins on our site.

Function Related Protein
identical protein bindingCDC42;NME1;BRAF;APPL1;ST13;FXR2;GRIK5;BCAT1;ANXA4
kinase bindingTRIP6;MIDN;DLG4;ABI2;SNAI1;PRKCD;PFKFB1;CAB39;SP100
protein bindingFNBP4;NXF1;VPS4B;TTC6;MAFB;PABPC1;MTDH;STX11;SPTSSA
receptor activityTRAM1;TMEM123;CCR6;ADIPOR1A;OGFRL1;KIR2DL1;OGFRL2;PAQR3B;TNFRSF25
signal transducer activityPTH1RA;PPP1R12A;OLFR470;LPAR6;PARAPINOPSINB;OLFR5;PLK2;PLCD4;ITGB3BP
tumor necrosis factor-activated receptor activityTNFRSF11A;Tnfrsf26;RELT;TNFRSF19;TNFRSF1A;HDR;TNFRSF6B;EDA2R;LTBR

FAS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FAS here. Most of them are supplied by our site. Hope this information will be useful for your research of FAS.

FADD

Choi, BD; Jeong, SJ; et al. The Effect of Thymosin beta 4 for Osteoblast Adhesion on Titanium Surface. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 15:5663-5667(2015).
Rutkowska, J; Bialek, M; et al. Differentiation of geographical origin of cream products in Poland according to their fatty acid profile. FOOD CHEMISTRY 178:26-31(2015).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
Does FAS protein play a role in cell signaling? 10/30/2022

FAS protein plays an important role in cell signaling, it can activate downstream signaling pathways, such as death signaling pathway and survival signaling pathway, by binding to its ligand and transmitting signals.

Why apply knowledge of FAS proteins to clinical practice? 06/27/2022

It can provide a reference for clinical practice and guide the diagnosis, treatment and prevention of diseases by detecting the expression level of FAS protein and understanding its mechanism of action.

How can diseases associated with FAS protein be prevented and treated? 05/13/2022

FAS protein-related diseases can be prevented and treated by regulating the expression level of FAS protein and inhibiting its signaling pathway.

How can gene knockout or knockdown techniques be used to study the function of FAS proteins? 03/31/2021

Gene knockout or knockdown techniques can be used to study the function and mechanism of action of FAS proteins. By knocking out or knocking down the FAS gene, changes in processes such as apoptosis and immune response can be observed to further understand its function and mechanism of action.

What is the role of FAS protein in apoptosis? 09/29/2020

FAS protein can bind to its ligand, activate the death signaling pathway, and induce apoptosis.

How can FAS protein be used to predict disease prognosis? 06/19/2020

The expression level and activity of FAS protein can be measured to predict the prognosis and development trend of certain diseases.

Customer Reviews (3)

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Reviews
09/07/2022

    When experimenting with FAS, the results are very reproducible.

    07/29/2022

      The stability of FAS products allows them to cope with different experimental conditions and modes of operation.

      09/20/2021

        FAS has high specific activity and can exert strong biological effect at low concentration.

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