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AREG

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Official Full Name
amphiregulin
Background
The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells, and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). This protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. This encoded protein is associated with a psoriasis-like skin phenotype.
Synonyms
AREG; amphiregulin; schwannoma derived growth factor , SDGF; AR; Colorectum cell derived growth factor; CRDGF; A REG; MGC13647; Schwannoma derived growth factor; SDGF; OTTHUMP00000160473; OTTHUMP00000219184; schwannoma-derived growth factor; colorectum cell-derived growth factor; AREGB
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AREG Related Articles
>> Razis, E; Pentheroudakis, G; et al. EGFR gene gain and PTEN protein expression are favorable prognostic factors in patients with KRAS wild-type metastatic colorectal cancer treated with cetuximab. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 140:737-748(2014).
>> Strimpakos, A; Pentheroudakis, G; et al. The Prognostic Role of Ephrin A2 and Endothelial Growth Factor Receptor Pathway Mediators in Patients With Advanced Colorectal Cancer Treated With Cetuximab. CLINICAL COLORECTAL CANCER 12:267-274(2013).

45-1 Ramsey Road, Shirley, NY 11967, USA
USA: 1-631-559-9269  1-631-448-7888
Europe: 44-207-097-1828
FAX: 1-631-938-8127
EMAIL: info@creative-biomart.com

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