arnt2
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  • Official Full Name
  • aryl-hydrocarbon receptor nuclear translocator 2
  • Background
  • This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting addition roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively.
  • Synonyms
  • ARNT2; aryl-hydrocarbon receptor nuclear translocator 2; aryl hydrocarbon receptor nuclear translocator 2; bHLHe1; KIAA0307; ARNT protein 2; class E basic helix-loop-helix protein 1
Cat.#:ARNT2-841HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ARNT2 protein, GST-tagged
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Cat.#:ARNT2-1962MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ARNT2 Protein
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Cat.#:ARNT2-795RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ARNT2 Protein
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Cat.#:ARNT2-9202ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ARNT2
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Cat.#:ARNT2-8691HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ARNT2 293 Cell Lysate
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Involved Pathway

ARNT2 involved in several pathways and played different roles in them. We selected most pathways ARNT2 participated on our site, such as Pathways in cancer, Transcriptional misregulation in cancer, Renal cell carcinoma, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARNT2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Pathways in cancer
MMP2; RAD51; RAC2; WNT4; LAMA1; WNT2; CXCL12; IGF1; FZD1; TCF7L2
Transcriptional misregulation in cancer
SP1; RARA; SLC45A3; BIRC3; BCL2A1; HIST1H3E; HIST1H3A; ITGAM; RXRB; MEN1
Renal cell carcinoma
MET; RAC1; MAPK3; RBX1; KRAS; PIK3R5; FH; FLCN; AHA-1; TGFB3

Protein Function

ARNT2 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, aryl hydrocarbon receptor binding, protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ARNT2 itself. We selected most functions ARNT2 had, and list some proteins which have the same functions with ARNT2. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein NFIC; PER1; ZNF695; IRF4; NFAT5; NKX3-2; NEUROD6; MEOX2; NACC2; MYPOP
Function aryl hydrocarbon receptor binding
Related Protein ARNT; AIP; ARNT2; ARNTL
Function protein heterodimerization activity
Related Protein SMC1A; PML; SMAD1; SOX4; NFE2L2A; ADRA1B; HIST1H3A; PDGFA; ATF4; BCL2A1
Function transcription factor activity, sequence-specific DNA binding
Related Protein ESRRGA; POU3F2B; NR3C2; RXRBA; SHOX; HOXB2; TBX16; FOXA; NR2F2; PHOX2A
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein MITFA; DBP; IRF1; GABPA; ARID3B; HLTF; PGR; CDX4; ETV1; NR1H2

Interacting Protein

ARNT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARNT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARNT2.
TAX1BP3; USP7; SH3GL2; BCL6