Atg7
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Official Full Name
ATG7 autophagy related 7 homolog (S. cerevisiae)
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Overview
This gene was identified based on homology to Pichia pastoris GSA7 and Saccharomyces cerevisiae APG7. In the yeast, the protein appears to be required for fusion of peroxisomal and vacuolar membranes. The protein shows homology to the ATP-binding and catalytic sites of the E1 ubiquitin activating enzymes. -
Synonyms
ATG7; ATG7 autophagy related 7 homolog (S. cerevisiae); GSA7; APG7L; APG7-LIKE; DKFZp434N0735; APG7 autophagy 7-like (S. cerevisiae); Ubiquitin-like modifier-activating enzyme ATG7; ATG12-activating enzyme E1 ATG7; Autophagy-related protein 7; hAGP7; Ubiquitin-activating enzyme E1-like protein; OTTHUMP00000160157; OTTHUMP00000207591; OTTHUMP00000207592; ubiquitin activating enzyme E1-like protein;
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- Wheat Germ
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- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- Atg7 Related Articles
- Atg7 Related Research Area
Atg7 involved in several pathways and played different roles in them. We selected most pathways Atg7 participated on our site, such as Adaptive Immune System, Antigen processing: Ubiquitination &, Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with Atg7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adaptive Immune System | TRAT1;RAPGEF3;LRR1;SPSB1;CTSLL;LRSAM1;SIGLEC5;ASB14;KIF18A |
| Antigen processing: Ubiquitination & | RNF41;ASB17;RBCK1;TRIM11;SH3RF1;UBE2L6;LTN1;UBE2U;ASB18 |
| Proteasome degradation | DZIP3;GAN;IWS1;ASB4;LTN1;BLMH;ASB13;HUWE1;RNF25 |
| Cellular responses to stress | ATG9B;EHMT2;LAMTOR1;ERF;LAMTOR2;HIST1H1B;H1F0;BMI1B;POT1 |
| Class I MHC mediated antigen processing & | ASB3;LRR1;RNF6;SEC61B;UBE2V1;DTX3L;KLHL20;CYBA;TRIM41 |
| presentation | SH3RF1;DZIP3;SEC61B;ASB7;RNF14;RNF182;RNF4;CTSL1;TRAF7 |
| Immune System | SIGLEC9;CTS7;SLAMF6;WASF2;ACTR1B;DEFB125;TRIM63;CLEC2H;SIGLEC14 |
| Macroautophagy | AMBRA1A;ATG4A;ULK1A;MAP1LC3C;MAP1LC3B;AMBRA1B;WIPI1;WDR45L;ATG101 |
| Regulation of autophagy | IFNA7;IFNA1;GABARAPL1;IFNA5;INSB;ATG3;ATG16L1;GABARAPA;IFNA8 |
| Senescence and Autophagy | IL24;IFI16;MAP1LC3B;LC3;COL10A1;ATG7;ING1;MAP1LC3C;UVRAG |
Atg7 has several biochemical functions, for example, Atg12 activating enzyme activity, Atg8 activating enzyme activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Atg7 itself. We selected most functions Atg7 had, and list some proteins which have the same functions with Atg7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Atg12 activating enzyme activity | |
| Atg8 activating enzyme activity | |
| protein binding | TPP2;NSFL1C;EIF3A;Trf;SULT2B1;OFD1;PLA2G16;TRAPPC5;FAM110C |
| protein homodimerization activity | WRN;STK25;BAX;STC2;CASQ2;GRPEL2;BMP2B;NR4A2;PVRL3 |
| transcription factor binding | NFKB1;PIK3R1;MAPK1;PPP1R13B;SMAD2;IFI203;TCF12;NFATC3;TAF7L |
| ubiquitin activating enzyme activity | UBA6;UBA7;ATG7;UBE1Y1;UBA1;SAE1 |
Atg7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Atg7 here. Most of them are supplied by our site. Hope this information will be useful for your research of Atg7.
MAP1LC3B; GABARAP; GABARAPL2
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