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AARS

Official Full Name

alanyl-tRNA synthetase
Overview

The human alanyl-tRNA synthetase (AARS) belongs to a family of tRNA synthases, of the class II enzymes. Class II tRNA synthases evolved early in evolution and are highly conserved. This is reflected by the fact that 498 of the 968-residue polypeptide human AARS shares 41% identity witht the E.coli protein. tRNA synthases are the enzymes that interpret the RNA code and attach specific aminoacids to the tRNAs that contain the cognate trinucleotide anticodons. They consist of a catalytic domain which interacts with the amino acid acceptor-T psi C helix of the tRNA, and a second domain which interacts with the rest of the tRNA structure.
Synonyms

AARS; alanyl-tRNA synthetase; alanine--tRNA ligase, cytoplasmic; alanine tRNA ligase 1; cytoplasmic; alaRS; renal carcinoma antigen NY-REN-42; alanine tRNA ligase 1, cytoplasmic; alanyl-tRNA synthetase, cytoplasmic; CMT2N;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rat
Zebrafish

Source

E.coli
E.Coli or Yeast
HEK293
HEK293T
In Vitro Cell Free System
Insect Cell
Insect Cells
Mammalian Cell
Sf9 Insect Cell

Tag

C
His
GST
His (Fc)
Avi
Myc
DDK
Myc|DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	AARS-51H	Recombinant Human Alanyl-tRNA Synthetase, His-tagged	Sf9 Insect Cell	His		$298 / 20ug
Human	AARS-9196H	Recombinant Human AARS, GST-tagged	E.coli	GST	1-350a.a.	$319 / 25ug
Human	AARS-241H	Recombinant Human AARS Protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Human	AARS-757HF	Recombinant Full Length Human AARS Protein, GST-tagged	In Vitro Cell Free System	GST	968 amino acids	Inquiry
Human	AARS-459H	Recombinant Human AARS Protein (Met1-Asn968), His-tagged	Insect Cell	His	Met1-Asn968	Inquiry
Human	AARS-0409H	Recombinant Human AARS protein, His-tagged	E.coli	His	1-350 aa	$319 / 25ug
Mouse	Aars-2487M	Recombinant Mouse Aars protein(Met1-Asn968), His-tagged	Insect Cells	C-His	Met1-Asn968	Inquiry
Mouse	AARS-521MCL	Recombinant Mouse AARS cell lysate	Insect Cell	N/A		Inquiry
Mouse	Aars-1455M	Recombinant Mouse Aars Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Rat	AARS-386R	Recombinant Rat AARS Protein	Mammalian Cell	His		Inquiry
Rat	Aars-3250R	Recombinant Rat Aars, His-tagged	E.Coli or Yeast	His	968	Inquiry
Rat	AARS-41R	Recombinant Rat AARS Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	AARS-41R-B	Recombinant Rat AARS Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	AARS-3856Z	Recombinant Zebrafish AARS	Mammalian Cell	His		Inquiry
Chicken	AARS-1271C	Recombinant Chicken AARS	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
AARS Related Articles

AARS involved in several pathways and played different roles in them. We selected most pathways AARS participated on our site, such as Aminoacyl-tRNA biosynthesis, Cytosolic tRNA aminoacylation, Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with AARS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Aminoacyl-tRNA biosynthesis	EPRS;RARS;SEPSECS;MARS2;VARS;FARS2;RARS2;PET112L;NARS
Cytosolic tRNA aminoacylation	AARS;AIMP1;FARSB;MADD;KARS;AIMP2;EEF1E1;DARS
Gene Expression	THG1L;ZFP36L1B;TNPO1;DARS;CCNT2B;ZNF257;SF3B4;ESRRG;ZNF436
tRNA Aminoacylation	EARS2;KARS;DARS;AARS;FARS2;EEF1E1;AIMP1;AIMP2;WARS2

AARS has several biochemical functions, for example, ATP binding, alanine-tRNA ligase activity, amino acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AARS itself. We selected most functions AARS had, and list some proteins which have the same functions with AARS. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	BMP2K;CDK8;RPS6KB1;DDX51;WNK2;ATP8B5;ABCF3;SMARCAL1;GTF2F2B
alanine-tRNA ligase activity	AARS;AARSD1;AARS2
amino acid binding	TH;PAH;TPH2;OTC;TPH1A;KARS;DDAH1;TDO2;AGXT
aminoacyl-tRNA editing activity	DTD2;VARS;IARS2;LARS2;DTD1;VARS2;IARS;LARS;AARS
metal ion binding	BTR22;PPARDB;ADAM25;DCST1;MAP2K2;ZFP513;KDM5BA;MGAT4C;ITGAE
tRNA binding	EIF2AK4;PTCD1;TRNT1;IGHMBP2;TYW5;FARS2;TERT;METTL1;NSUN2

AARS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AARS here. Most of them are supplied by our site. Hope this information will be useful for your research of AARS.

VCAM1; ETS1; YWHAZ; 15-deoxy-delta(12,14; ere_dna; FN1; HSP90AB1; Calml3

Zimmerman, ES; Heibeck, TH; et al. Production of Site-Specific Antibody-Drug Conjugates Using Optimized Non-Natural Amino Acids in a Cell-Free Expression System. BIOCONJUGATE CHEMISTRY 25:351-361(2014).

Gono, T; Kawaguchi, Y; et al. Brief Report Association of HLA-DRB1*0101/*0405 with susceptibility to anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis in the Japanese population. ARTHRITIS AND RHEUMATISM 64:3736-3740(2012).