AGT
-
Official Full Name
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
-
Overview
The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. -
Synonyms
AGT; angiotensinogen (serpin peptidase inhibitor, clade A, member 8); ANHU; SERPINA8;
- Recombinant Proteins
- Cell & Tissue Lysates
- Transfected Stable Cell Lines
- Native Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- E.Coli or Yeast
- HEK293
- HEK293F
- HEK293T
- Human Cell
- Human Plasma
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- His
- Flag
- GST
- His (Fc)
- Avi
- His|GST
- His|S
- SUMO
- Myc
- DDK
- MYC
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- AGT Related Articles
- AGT Related Signal Pathway
AGT involved in several pathways and played different roles in them. We selected most pathways AGT participated on our site, such as ACE Inhibitor Pathway, Adipogenesis, Class A/1 (Rhodopsin-like receptors), which may be useful for your reference. Also, other proteins which involved in the same pathway with AGT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
ACE Inhibitor Pathway | CYP11B2;AGTR2;CMA1;CTSG;AGTR1;ATP6AP2;AGT;ACE |
Adipogenesis | MIXL1;SMAD3B;EPAS1B;DVL1;NAMPT;HMGA1;CFD;NDN;GDF10 |
Class A/1 (Rhodopsin-like receptors) | NMU;PROKR2;OPN5;CHRM4;AGTR2;FPR-RS6;APLN;RGR;CCR9 |
Fatty acid, triacylglycerol, and ketone body metabolism | MED16;Agmo;MTF1;CDK19;ACOT11B;TIAM2;STIL;SLC25A20;ACSF2 |
G alpha (i) signalling events | SSTR4;TAS2R16;RGS6;APPB;OXGR1A.3;ANXA1C;OPN1LW2;CCR8;CCR9 |
G alpha (q) signalling events | ANXA1;TRH;TRPC6A;NPS;NMU;OPN4B;EDNRB;TRIO;FFAR3 |
GPCR downstream signaling | GHRH;RGS21;SST1.1;TIAM2;ITSN1;CCK;CXCL13;TAS2R13;GPR132B |
GPCR ligand binding | PTHRP2;ADORA1;S1PR5B;OPN1SW;GNB5A;CALCB;CNR2;APLNR;PPY |
AGT has several biochemical functions, for example, growth factor activity, hormone activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AGT itself. We selected most functions AGT had, and list some proteins which have the same functions with AGT. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
growth factor activity | GDF9;FGF11;GPI1;JAG2;HBEGFA;FGF20;FBRS;AMBN;NRG4 |
hormone activity | BNP;CSH2;ADM;SST;PYY;TTR;PTH1A;LEP;SST1.1 |
protein binding | HNRNPC;TPD52;ZNF286A;P2RY6;LILRA4;USP37;VPS37A;KIAA0146;KRR1 |
serine-type endopeptidase inhibitor activity | CCNH;SPINK4;Serpina1c;ITIH2;SERPINA5;SPINK1;HRG;WFIKKN2;SERPINB6 |
sodium channel regulator activity | FGF13;FXYD4;PRSS30;PKP2;FXYD7;AGT;RANGRF;GPLD1;FXYD5 |
superoxide-generating NADPH oxidase activator activity | PDGFB;NOXO1;NOXA1;NCF4;AGT |
type 1 angiotensin receptor binding | GNB1;GNG3;JAK2;AGT;ARAP1;GNA13A;GNA13;ARRB2;GNA13B |
type 2 angiotensin receptor binding |
AGT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AGT here. Most of them are supplied by our site. Hope this information will be useful for your research of AGT.
Ance; Agtr1; f_hcvh; GRB2; EWSR1; GSDMB
- Q&As
- Reviews
Q&As (10)
Ask a questionAGT is produced and released by the kidneys, and it plays a role in regulating renal blood flow and glomerular filtration rate, thereby impacting overall kidney function.
AGT is the precursor molecule for angiotensin peptides, including angiotensin I and angiotensin II, which are key regulators of blood pressure, fluid balance, and cardiovascular homeostasis.
AGT-derived angiotensin II plays a critical role in vasoconstriction, sodium reabsorption, and the regulation of aldosterone secretion, all of which influence blood pressure.
AGT and the renin-angiotensin system have been implicated in the central regulation of blood pressure, fluid balance, and neuroendocrine functions.
AGT is cleaved by the enzyme renin to generate angiotensin I, which is subsequently converted to angiotensin II by the enzyme angiotensin-converting enzyme (ACE).
AGT expression is regulated by various factors, including hormones (such as aldosterone and glucocorticoids), cytokines, and environmental stimuli.
AGT and its derivatives, such as angiotensin II, can promote inflammation and tissue remodeling through interactions with receptors and signaling pathways.
Experimental techniques used to study AGT include molecular biology approaches, gene expression analysis, protein quantification, immunohistochemistry, and animal models.
Genetic variations in the AGT gene have been associated with an increased risk of hypertension, cardiovascular diseases, and other conditions influenced by the renin-angiotensin system.
AGT levels and the renin-angiotensin system play a role in regulating blood pressure during pregnancy, and dysregulation can contribute to disorders such as preeclampsia.
Customer Reviews (5)
Write a reviewThe proteins offering reliable results and contributing to the success of my experiments.
The customer service team was incredibly helpful and responsive to my inquiries.
The product allowed me to access high-quality reagents while staying within my budget.
The ordering process was seamless, and the company's efficient shipping ensured that I received the recombinant proteins promptly and in excellent condition.
Ask a Question for All AGT Products
Required fields are marked with *
My Review for All AGT Products
Required fields are marked with *