AQP9
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Official Full Name
aquaporin 9
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Overview
solute channel involved in passage of carbamides, polyols, purines, and pyrimidines -
Synonyms
AQP9; aquaporin 9; aquaporin-9; HsT17287; SSC1; aquaglyceroporin-9; small solute channel 1; AQP-9;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Homo sapiens (Human)
- Human
- Milnesium tardigradum (Water bear) (Tardigrade)
- Mouse
- Mus musculus (Mouse)
- Rat
- Rattus norvegicus (Rat)
- E.coli
- E.coli expression system
- E.Coli or Yeast
- HEK293
- HEK293T
- Mammalian Cell
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- N
- GST
- Tag
- Free
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | AQP9-3608H | Recombinant Human AQP9 protein, MYC/DDK-tagged | HEK293 | Myc/DDK | ||
Human | AQP9-3607H | Recombinant Human AQP9, His-tagged | E.Coli or Yeast | His | 295 | |
Human | AQP9-9786H | Recombinant Human AQP9, His-tagged | E.coli | His | C-term-85a.a. | |
Human | AQP9-8765HCL | Recombinant Human AQP9 293 Cell Lysate | HEK293 | N/A | ||
Human | AQP9-0083H | Recombinant Human AQP9 Protein (Tyr125-Leu158), N-GST-tagged | E.coli | N-GST | Tyr125-Leu158 | |
Human | AQP9-5110H | Recombinant Human AQP9 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK | ||
Mouse | Aqp9-39M | Recombinant Mouse Aqp9 protein, His-tagged | E.coli | His | Glu4~Asn285 | |
Mouse | Aqp9-1672M | Recombinant Mouse Aqp9 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK | ||
Rat | Aqp9-3606R | Recombinant Rat Aqp9, His-tagged | E.Coli or Yeast | His | 295 | |
Rat | AQP9-742R | Recombinant Rat AQP9 Protein | Mammalian Cell | His | ||
Rat | AQP9-398R-B | Recombinant Rat AQP9 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | AQP9-398R | Recombinant Rat AQP9 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Homo sapiens (Human) | RFL-36891HF | Recombinant Full Length Human Aquaporin-9(Aqp9) Protein, His-Tagged | E.coli expression system | His | Full Length (1-295) | |
Milnesium tardigradum (Water bear) (Tardigrade) | RFL1276MF | Recombinant Full Length Milnesium Tardigradum Aquaporin-9(Aqp9) Protein, Tag-Free | E.coli expression system | Tag-Free | Full Length (1-281) | |
Mus musculus (Mouse) | RFL1498MF | Recombinant Full Length Mouse Aquaporin-9(Aqp9) Protein, His-Tagged | E.coli expression system | His | Full Length (1-295) | |
Rattus norvegicus (Rat) | RFL-3222RF | Recombinant Full Length Rat Aquaporin-9(Aqp9) Protein, His-Tagged | E.coli expression system | His | Full Length (1-295) | |
Chicken | AQP9-5559C | Recombinant Chicken AQP9 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- AQP9 Related Articles
AQP9 involved in several pathways and played different roles in them. We selected most pathways AQP9 participated on our site, such as Bile secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with AQP9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Bile secretion | SLCO1B1;ABCB1A;PRKACG;SLC22A7;SLC9A3;CYP7A1;Adcy4;SLC22A8;SLC22A1 |
AQP9 has several biochemical functions, for example, amine transmembrane transporter activity, carboxylic acid transmembrane transporter activity, glycerol channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AQP9 itself. We selected most functions AQP9 had, and list some proteins which have the same functions with AQP9. You can find most of the proteins on our site.
Function | Related Protein |
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amine transmembrane transporter activity | SLC7A8;SLC22A16;AQP9 |
carboxylic acid transmembrane transporter activity | |
glycerol channel activity | AQP3;AQP3A;MIPA;AQP8B;AQP8A.2;AQP9;AQP4;AQP3B;AQP8A.1 |
polyol transmembrane transporter activity | |
porin activity | AQP9;TOMM40;VDAC2;VDAC3;TOMM40L;VDAC1 |
purine nucleobase transmembrane transporter activity | |
pyrimidine nucleobase transmembrane transporter activity | |
urea transmembrane transporter activity | AQP10;AQP9;AQP9B;AQP7;AQP9A;AQP10A;AQP3B;AQP8A.2;AQP3 |
water channel activity | AQP2;AQP1A.2;AQP4;AQP3A;AQP9;AQP10A;AQP5;AQP10B;AQP8A.2 |
water transmembrane transporter activity | AQP10A;AQP10B;AQP3B;AQP8A.2;AQP9;AQP2;AQP3A;AQP8B;AQP1A.2 |
AQP9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AQP9 here. Most of them are supplied by our site. Hope this information will be useful for your research of AQP9.
- Q&As
- Reviews
Q&As (30)
Ask a questionYes, dysregulation of AQP9 has been implicated in various pathologies. For example, altered expression or function of AQP9 has been associated with liver diseases, such as non-alcoholic fatty liver disease and liver cancer. Additionally, AQP9 dysregulation may also contribute to conditions like obesity and diabetes.
Yes, several genetic mutations and polymorphisms have been identified in the AQP9 gene. These variations in the gene sequence can lead to altered expression or function of AQP9 and may be associated with certain diseases or conditions. However, the specific impact of these genetic variations on AQP9 function and their clinical significance is still being investigated.
Yes, several genetic mutations and polymorphisms have been identified in the AQP9 gene. These variations in the gene sequence can lead to altered expression or function of AQP9 and may be associated with certain diseases or conditions. However, the specific impact of these genetic variations on AQP9 function and their clinical significance is still being investigated.
AQP9 is primarily expressed in tissues and organs involved in metabolism, such as the liver, adipose tissue, kidney, and intestine.
Currently, there are no specific inhibitors or activators that exclusively target AQP9. However, certain compounds, such as mercury chloride, have been reported to inhibit AQP9 activity, although they may also affect other aquaporins.
While AQP9 is not highly expressed in the blood-brain barrier, it has been detected in certain brain regions. Its role in water and solute transport in the brain is not completely understood, but studies suggest that AQP9 may play a role in maintaining brain osmotic balance and energy metabolism.
Yes, AQP9 has been implicated in immune cell function. It is expressed in lymphoid tissues, such as the spleen and lymph nodes, and may contribute to immune cell migration and activation by facilitating the transport of small molecules required for immune responses.
Yes, AQP9 has been implicated in influencing the transport of certain drugs. Its expression in the liver, intestine, and kidney suggests that it may play a role in drug absorption, distribution, and excretion. Modulating AQP9 activity could potentially impact drug efficacy and toxicity.
No, AQP9 is not present in all tissues and organs. Its expression is primarily found in tissues involved in metabolic processes, such as the liver, kidney, adipose tissue, and gastrointestinal tract. AQP9 expression may vary between different cell types within a tissue, reflecting their specific roles and metabolic functions.
No, AQP9 is not present in all tissues and organs. Its expression is primarily found in tissues involved in metabolic processes, such as the liver, kidney, adipose tissue, and gastrointestinal tract. AQP9 expression may vary between different cell types within a tissue, reflecting their specific roles and metabolic functions.
Several compounds have been identified as potential inhibitors of AQP9. For example, phloretin and its derivatives have been shown to inhibit AQP9-mediated glycerol transport. However, further research is needed to develop more specific and effective inhibitors that can selectively target AQP9 without interfering with other aquaporin proteins or essential physiological functions.
Yes, AQP9 expression can be modulated by various environmental factors and external stimuli. For example, changes in osmolarity, cytokines, hormones, and certain drugs can influence AQP9 expression levels. These regulatory mechanisms allow cells to adapt to different physiological conditions and respond to external signals.
Yes, AQP9 expression can be modulated by various environmental factors and external stimuli. For example, changes in osmolarity, cytokines, hormones, and certain drugs can influence AQP9 expression levels. These regulatory mechanisms allow cells to adapt to different physiological conditions and respond to external signals.
AQP9 belongs to a subfamily of aquaporin proteins known as the aquaglyceroporins. Other aquaglyceroporins include AQP3, AQP7, and AQP10, which also facilitate the transport of water and small solutes like glycerol and urea.
AQP9 belongs to a subfamily of aquaporin proteins known as the aquaglyceroporins. Other aquaglyceroporins include AQP3, AQP7, and AQP10, which also facilitate the transport of water and small solutes like glycerol and urea.
Yes, several genetic variations and mutations in the AQP9 gene have been identified. Some of these variations have been associated with altered glycerol and water transport, and are linked to conditions such as obesity and metabolic syndrome.
Dysregulation of AQP9 has been implicated in various diseases and conditions. For example, altered AQP9 expression has been observed in obesity, type 2 diabetes, liver cirrhosis, and certain kidney disorders. Additionally, AQP9 has been associated with tumor growth and progression in certain types of cancer.
Dysregulation of AQP9 has been implicated in various diseases and conditions. For example, altered AQP9 expression has been observed in obesity, type 2 diabetes, liver cirrhosis, and certain kidney disorders. Additionally, AQP9 has been associated with tumor growth and progression in certain types of cancer.
While there are limited clinical trials specifically targeting AQP9, ongoing research is exploring its role in various diseases. Studies are investigating the association between AQP9 polymorphisms and metabolic disorders, as well as the potential therapeutic implications of modulating AQP9 function in liver diseases and other conditions.
While there are limited clinical trials specifically targeting AQP9, ongoing research is exploring its role in various diseases. Studies are investigating the association between AQP9 polymorphisms and metabolic disorders, as well as the potential therapeutic implications of modulating AQP9 function in liver diseases and other conditions.
Modulating AQP9 function or expression using drugs or therapies is an area of ongoing research. While specific drugs targeting AQP9 are not currently available, compounds that influence AQP9 activity or expression indirectly, such as hormones or cytokines, may have therapeutic potential.
Modulating AQP9 function or expression using drugs or therapies is an area of ongoing research. While specific drugs targeting AQP9 are not currently available, compounds that influence AQP9 activity or expression indirectly, such as hormones or cytokines, may have therapeutic potential.
Modulating AQP9 function holds potential therapeutic value, particularly in conditions where glycerol and metabolite transport is dysregulated, such as liver diseases and metabolic disorders. However, further research is needed to understand the complex roles of AQP9 and develop suitable strategies for therapeutic interventions.
There is accumulating evidence suggesting that AQP9 may contribute to drug resistance in various types of cancer. Studies have shown that AQP9 expression can enhance the efflux of anticancer drugs from cancer cells, reducing their effectiveness. Targeting AQP9-mediated drug efflux is being explored as a potential strategy to overcome drug resistance in cancer therapy.
There is accumulating evidence suggesting that AQP9 may contribute to drug resistance in various types of cancer. Studies have shown that AQP9 expression can enhance the efflux of anticancer drugs from cancer cells, reducing their effectiveness. Targeting AQP9-mediated drug efflux is being explored as a potential strategy to overcome drug resistance in cancer therapy.
Yes, in addition to water and glycerol, AQP9 also facilitates the transport of other solutes, including urea and various metabolites. This versatile transport capacity makes AQP9 important in maintaining overall cellular homeostasis.
Yes, in addition to glycerol, AQP9 is capable of transporting other solutes, including urea and monocarboxylates like lactate and pyruvate. The relative contribution of these solutes to AQP9-mediated transport may vary depending on the tissue and physiological conditions.
Yes, in addition to glycerol, AQP9 is capable of transporting other solutes, including urea and monocarboxylates like lactate and pyruvate. The relative contribution of these solutes to AQP9-mediated transport may vary depending on the tissue and physiological conditions.
Yes, given the involvement of AQP9 in glycerol metabolism and the liver's role in lipid and glucose metabolism, modulating AQP9 function has been proposed as a potential therapeutic strategy for liver diseases. However, further research is needed to fully understand the mechanisms and potential benefits of targeting AQP9 in liver disorders.
Yes, given the involvement of AQP9 in glycerol metabolism and the liver's role in lipid and glucose metabolism, modulating AQP9 function has been proposed as a potential therapeutic strategy for liver diseases. However, further research is needed to fully understand the mechanisms and potential benefits of targeting AQP9 in liver disorders.
Customer Reviews (8)
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In addition to its high-quality standards, the manufacturer of AQP9 protein offers excellent technical support.
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