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BAI1

  • Official Full Name

    brain-specific angiogenesis inhibitor 1

  • Overview

    Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed;under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid;tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels;as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1;contains at least one functional p53-binding site within an intron, and its expression has been shown to be induced;by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along;with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53.BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth;suppressor of glioblastomas.
  • Synonyms

    BAI1; brain-specific angiogenesis inhibitor 1; GDAIF; FLJ41988;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human BAI1-921H Active Recombinant Human BAI1 Protein, His-tagged CHO His Ala31-Thr879
Human BAI1-295H Recombinant Human BAI1 Protein, His&GST-tagged E.coli N-His&GST Ala31-Pro350
Mouse BAI1-2278M Recombinant Mouse BAI1 Protein Mammalian Cell His
Mouse BAI1-955M-B Recombinant Mouse BAI1 Protein Pre-coupled Magnetic Beads HEK293
Mouse BAI1-955M Recombinant Mouse BAI1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • BAI1 Related Articles

BAI1 involved in several pathways and played different roles in them. We selected most pathways BAI1 participated on our site, such as p signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BAI1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
p signaling pathwayRFWD2;CCNB1;GADD45B;SESN1;GADD45AA;SFN;IGFBP3;CASP8;CCND2

BAI1 has several biochemical functions, for example, G-protein coupled receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BAI1 itself. We selected most functions BAI1 had, and list some proteins which have the same functions with BAI1. You can find most of the proteins on our site.

Function Related Protein
G-protein coupled receptor activityOXGR1A.2;OPN1MW3;OR51D1;VMN1R44;V2RX1;OR10W1;DRD2A;GPR63;NPY8BR

BAI1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BAI1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BAI1.

MAGI3; BAIAP3; EIF3H; Dlg4

Sokolowski, JD; Nobles, SL; et al. Brain-specific angiogenesis inhibitor-1 expression in astrocytes and neurons: Implications for its dual function as an apoptotic engulfment receptor. BRAIN BEHAVIOR AND IMMUNITY 25:915-921(2011).
Zhao, P; Gao, CF; et al. Repeated hepatocyte growth factor neutralizing antibody treatment leads to HGF/SF unresponsiveness in human glioblastoma multiforme cells. CANCER LETTERS 291:209-216(2010).
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