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BAK1

Official Full Name

BCL2-antagonist/killer 1
Overview

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress. [provided by RefSeq, Jul 2008]
Synonyms

BAK1; BCL2-antagonist/killer 1; BAK; CDN1; BCL2L7; BAK-LIKE; bcl-2 homologous antagonist/killer; bcl2-L-7; BCL2-like 7 protein; bcl-2-like protein 7; apoptosis regulator BAK; pro-apoptotic protein BAK;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Homo sapiens (Human)
Human
Mus musculus (Mouse)
Rhesus Macaque

Source

E. coli
E.coli expression system
HEK293
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	BAK1-26166TH	Recombinant Human BAK1 Protein, GST-tagged	Wheat Germ	GST	1 a.a. - 211 a.a.	Inquiry
Human	BAK1-26168TH	Recombinant Human BAK1	Wheat Germ	N/A	112 amino acids	Inquiry
Human	BAK1-8519HCL	Recombinant Human BAK1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	BAK1-35H	Recombinant Human BAK1 Protein, His-tagged	E. coli	His		Inquiry
Homo sapiens (Human)	RFL36987HF	Recombinant Full Length Human Bcl-2 Homologous Antagonist/Killer(Bak1) Protein, His-Tagged	E.coli expression system	His	Full Length (1-211)	Inquiry
Mus musculus (Mouse)	RFL9990MF	Recombinant Full Length Mouse Bcl-2 Homologous Antagonist/Killer(Bak1) Protein, His-Tagged	E.coli expression system	His	Full Length (1-208)	Inquiry
Rhesus Macaque	BAK1-509R	Recombinant Rhesus monkey BAK1 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	BAK1-337R-B	Recombinant Rhesus Macaque BAK1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rhesus Macaque	BAK1-337R	Recombinant Rhesus Macaque BAK1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Chicken	BAK1-2609C	Recombinant Chicken BAK1	Mammalian Cell	His		Inquiry

BAK1 involved in several pathways and played different roles in them. We selected most pathways BAK1 participated on our site, such as Protein processing in endoplasmic reticulum, Viral carcinogenesis, MicroRNAs in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with BAK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Protein processing in endoplasmic reticulum	ATXN3;HSP26;DAD1;SEL1L;UBE2D1B;VIMP;DNAJB11;CAPN1;STT3A
Viral carcinogenesis	GTF2H2C;HDAC4;RBL2;GTF2E2;RANBP1;HIST1H4K;CDK1;CCNA1;HDAC7
MicroRNAs in cancer	PDCD4;ITGB3;ZEB1;DNMT1;DICER1;DNMT3A;MCL1;PLCG2;RASSF1

BAK1 has several biochemical functions, for example, BH domain binding, chaperone binding, heat shock protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BAK1 itself. We selected most functions BAK1 had, and list some proteins which have the same functions with BAK1. You can find most of the proteins on our site.

Function	Related Protein
BH domain binding	BOK;BAK1;BIK;Bcl2a1b;BCL2L2;BCL2A1A
chaperone binding	H2-KE2;C1orf182;DNAJA2;CLU;GET4;BAG5;DNAJA3A;TG;CXorf41
heat shock protein binding	BAX;TPR;NFKB1;DAXX;TFAM;TOMM34;SSUH2RS1;HSPA8;SSUH2.2
identical protein binding	TRIM55;Serpina1c;VEGFA;TRIM39;COL1A2;C14orf166;ADORA2A;PLDN;GCG
ion channel binding	NOS1;CTNNB1;TRPC1;S100A10;PDE4D;ANK2;PRNP;KCNE4;FAM115C
metal ion binding	ZNF143B;RNF17;GLI4;AGAP1;DNMT3B;ME2;GDPD3;PRIM2;SRSF7A
protein binding	MYCN;TCEA2;TIMM21;CDX4;SOX1;CDC25A;BAI3;TRIP12;KIFC3
protein heterodimerization activity	CUL3;PKNOX1;HIF1A;MYH7;LTC4S;UGT1A1;UGT1A9;TPD52L1;HIST1H2A9
protein homodimerization activity	Defa-rs7;SMAD3;FAP;HLCS;ASGR1;CTBP2A;NRF1;UGT1A1;NACC2

BAK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BAK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BAK1.

MCL1; BCL2L1

Lauf, PK; Alqahtani, T; et al. Interaction between Na-K-ATPase and Bcl-2 proteins BclXL and Bak. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 308:C51-C60(2015).

Jin, XH; Wu, XX; et al. Delineation of apoptotic genes for synergistic apoptosis of lexatumumab and anthracyclines in human renal cell carcinoma cells by polymerase chain reaction array. ANTI-CANCER DRUGS 23:445-454(2012).

Bcl-2 Family