Bax
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Official Full Name
BCL2-associated X protein
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Overview
This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. -
Synonyms
BAX; bcl2-L-4; BCL2L4; Bcl2-L-4; BCL2-associated X protein; Bcl-2-associated X protein; Apoptosis regulator BAX; apoptosis regulator BAX; Bcl-2-like protein 4; bcl-2-like protein 4; OTTHUMP00000218291; OTTHUMP00000218292; OTTHUMP00000218293; OTTHUMP00000218294; OTTHUMP00000218295; OTTHUMP00000218296;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bos taurus (Bovine)
- Human
- Mouse
- Pig
- Rattus norvegicus (Rat)
- Rhesus Macaque
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- Human cells
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Protein Conjugation
- Wheat Germ
- C
- His
- DYKDDDDK
- Flag
- GST
- His (Fc)
- Avi
- Myc
- DDK
- MYC
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- Bax Related Articles
- Bax Related Gene Family
- Bax Related Research Area
- Bax Related Signal Pathway
Bax involved in several pathways and played different roles in them. We selected most pathways Bax participated on our site, such as Sphingolipid signaling pathway, p signaling pathway, Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with Bax were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Sphingolipid signaling pathway | S1PR2;MAP3K5;AKT2;ROCK1;SPTLC1;NSMAF;PRKCB;PLCB4;MAPK10 |
p signaling pathway | CCNE2;STEAP3;FAS;CCND3;BAX;IGFBP3;GADD45BA;PTENA;SFN |
Protein processing in endoplasmic reticulum | CUL1B;UBE2J2;CANX;UBQLN1;CAPN2A;RNF185;NSFL1C;YOD1;DNAJB12A |
Apoptosis | HELLS;PPP3CB;BCL2L1;Fasl;CASP12;BCL2L11;CAPN2B;TNFRSFA;BCL2 |
Neurotrophin signaling pathway | FASLG;RAP1B;KRAS;MAPK8;NFKBIB;MAPK3;ZNF274;SHC1;MAPK1 |
Non-alcoholic fatty liver disease (NAFLD) | RAC1;NDUFV1;MAPK9;PIK3R1;PPARA;PIK3CD;NDUFV2;PRKAA2;MLXIPL |
Amyotrophic lateral sclerosis (ALS) | DAXX;BCL2;NOS1;CASP1;PPP3CC;BAX;PPP3CB;CASP9;TOMM40L |
Huntingtons disease | NDUFS6;TRP53;DNAIC2;UQCRC2;POLR2A;POLR2D;TP53;POLR2K;TGM2 |
Prion diseases | Hc;STIP1;C9;MAP2K1;C5;LOC100033925;SOD1;BAX;C1QB |
Tuberculosis | Casp3;CD209;BCL10;PPP3CC;CASP10;NOS2;Ifna15;HLA-DMA;MYD88 |
Hepatitis B | IFNA16;IKBKG;TP53;DDX58;Casp3;CASP9;EGR2;ATP6AP1;IKBKE |
HTLV-I infection | ZFP36;IL2RA;MAP3K14;SMAD4;HLA-DRA;MAP3K1;FOS;PIK3CA;HLA-DRB3 |
Pathways in cancer | WNT3;RALGDS;MAPK10;FGF22;BDKRB1;TRAF3;GNB2;FLT3;FZD10 |
Viral carcinogenesis | HNRNPK;HIST2H2BE;H2-Q10;DNAJA3;GTF2A1;SYK;PIK3R1;CDK1;UBR4 |
Colorectal cancer | CCND1;BIRC5;TGFB3;MAP2K1;Casp3;PIK3CD;CYCS;LEF1;PIK3CG |
Bax has several biochemical functions, for example, BH3 domain binding, channel activity, chaperone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Bax itself. We selected most functions Bax had, and list some proteins which have the same functions with Bax. You can find most of the proteins on our site.
Function | Related Protein |
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BH3 domain binding | MCL1;BCL2;BAX;BCL2L1 |
channel activity | TRPA1;GJA8;PANX1A;MAL;CHRNB1;BAXA;BAXB;BAX;STEAP1 |
chaperone binding | BAG4;TBCA;HSPE1;TIMM9;ATP1A3;CP;SYVN1;BAK1;GRPEL1 |
heat shock protein binding | KCNJ11;GM5506;SSUH2RS1;CDC37;DNAJC9;PACRG;HSPA1A;TPR;HSPA1L |
identical protein binding | MMP9;CEP57L1;C1QTNF9;EDC3;ACTB;MAPK1IP1;RILPL2;HCN2;C1QTNF2 |
lipid binding | CRABP1A;ZFYVE26;ALOX8;PAQR7B;APOA2;ACOT12;CYTH4;PITPNB;S1PR3 |
protein binding | CRYBB3;CGA;DYDC1;KIAA0319L;MRPS23;TUBA1B;GRIN2A;ZNF614;LACTB2 |
protein complex binding | RIPK3;KRT8;ST13;EPHB1;KCTD5;ULK1;STRN4;STRN;NSF |
protein heterodimerization activity | H2-AA;TENM2;ATF6;KCNN1;AXL;DMBX1;P4HB;TPD52L2;CABYR |
protein homodimerization activity | MIXL1;DSCAML1;KIAA0947;CEACAM5;JAM3;CALCOCO2;TPD52;ENG;NR6A1A |
Bax has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Bax here. Most of them are supplied by our site. Hope this information will be useful for your research of Bax.
- Q&As
- Reviews
Q&As (7)
Ask a questionSome genetic mutations in BAX are associated with cancer.
Strategies include modulating BAX activity for cancer therapy and neurodegenerative diseases.
BAX can form heterodimers with anti-apoptotic Bcl-2 proteins, or homodimers to promote apoptosis.
Dysregulation can lead to excessive cell death or contribute to cancer.
BAX promotes apoptosis by permeabilizing the mitochondrial membrane.
Stress signals or cellular damage can trigger BAX activation.
It is regulated by various members of the Bcl-2 family and other signaling pathways.
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