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BIK

Official Full Name

BCL2-interacting killer (apoptosis-inducing)
Overview

Bik/Nbk (Bcl-2-interacting killer/natural born killer) is a potent pro-apoptotic protein belonging to a group of Bcl-2 family members that includes Bad, Bid, Bim, Hrk, and Noxa, containing a BH3 domain but lacking other conserved domains, BH1 or BH2. Func
Synonyms

BIK; BCL2-interacting killer (apoptosis-inducing); bcl-2-interacting killer; NBK; apoptosis inducer NBK; apoptosis-inducing NBK; BP4; BIP1;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Homo sapiens (Human)
Human
Mouse
Zebrafish

Source

E.coli
E.coli expression system
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	BIK-219H	Recombinant Human BIK Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	BIK-769H	Recombinant Human BIK Protein, His-tagged	E.coli	His		Inquiry
Human	BIK-220H	Recombinant Human BIK Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	BIK-65HCL	Recombinant Human BIK lysate	HEK293	N/A		Inquiry
Human	BIK-1626HF	Recombinant Full Length Human BIK Protein, GST-tagged	In Vitro Cell Free System	GST	160 amino acids	Inquiry
Mouse	BIK-2405M	Recombinant Mouse BIK Protein	Mammalian Cell	His		Inquiry
Mouse	BIK-1033M	Recombinant Mouse BIK Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	BIK-1033M-B	Recombinant Mouse BIK Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Homo sapiens (Human)	RFL31368HF	Recombinant Full Length Human Bcl-2-Interacting Killer(Bik) Protein, His-Tagged	E.coli expression system	His	Full Length (1-160)	Inquiry
Zebrafish	BIK-4106Z	Recombinant Zebrafish BIK	Mammalian Cell	His		Inquiry
Chicken	BIK-5334C	Recombinant Chicken BIK	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
BIK Related Articles
BIK Related Research Area

BIK involved in several pathways and played different roles in them. We selected most pathways BIK participated on our site, such as Apoptosis Modulation and Signaling, DNA damage response (only ATM dependent), which may be useful for your reference. Also, other proteins which involved in the same pathway with BIK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Apoptosis Modulation and Signaling	DIABLO;CAPNS1;CDKN2A;BCL2L10;BCL2L11;BLK;SEPT4;BAG3;PTRH2
DNA damage response (only ATM dependent)	MLKL;BIK;DVL2;DVL3;DVL1

BIK has several biochemical functions, for example, BH domain binding, protein binding, protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BIK itself. We selected most functions BIK had, and list some proteins which have the same functions with BIK. You can find most of the proteins on our site.

Function	Related Protein
BH domain binding	BCL2A1A;BIK;BAK1;Bcl2a1b;BOK;BCL2L2
protein binding	STOX1;ACTB;CRABP1;NFATC3;C16orf87;SNX15;SERPINI2;MGST3;FIBCD1
protein heterodimerization activity	CYBB;UGT1A2;MCL1;LIMK2;EFHA1;MEF2A;HIST3H2BB;KCNK9;DRD1

BIK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BIK here. Most of them are supplied by our site. Hope this information will be useful for your research of BIK.

BCL2L2; BCL2; FATE1; BCL2L1; BCL2L1; BCL2A1

Albrechtsen, R; Kveiborg, M; et al. ADAM12 redistributes and activates MMP-14, resulting in gelatin degradation, reduced apoptosis and increased tumor growth. JOURNAL OF CELL SCIENCE 126:4707-4720(2013).

Sung, ES; Park, KJ; et al. The proteasome inhibitor MG132 potentiates TRAIL receptor agonist-induced apoptosis by stabilizing tBid and Bik in human head and neck squamous cell carcinoma cells. EXPERIMENTAL CELL RESEARCH 318:1564-1576(2012).

Bcl-2 Family