BIRC7
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Official Full Name
baculoviral IAP repeat containing 7
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Overview
PUMA (p53 up-regulated modulator of apoptosis) is one of the pro-apoptotic Bcl-2 family members that are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-alpha and PUMA-beta. PUMA proteins bind Bcl- -
Synonyms
BIRC7; baculoviral IAP repeat containing 7; baculoviral IAP repeat-containing protein 7; KIAP; kidney inhibitor of apoptosis protein; livin; livin inhibitor of apoptosis; melanoma inhibitor of apoptosis protein; ML IAP; mliap; RNF50; RING finger protein 5;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Zebrafish
- E. coli
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- His
- Flag
- GST
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- BIRC7 Related Articles
- BIRC7 Related Research Area
BIRC7 involved in several pathways and played different roles in them. We selected most pathways BIRC7 participated on our site, such as Ubiquitin mediated proteolysis, Apoptosis, Toxoplasmosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with BIRC7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Ubiquitin mediated proteolysis | SOCS3;HUWE1;FLJ11011L;UBE2M;SOCS1;UBA1;ITCH;UBE2E1;UBA2 |
Apoptosis | TNFRSF10A;IRF1B;BMX;RIPK1L;STK24B;TNFRSF1A;IRAK3;BNIP3L;BADB |
Toxoplasmosis | GNAI3;PDPK1;TNFRSF1A;LAMA3;IL10RA;PIK3CD;XIAP;TRAF6;ALOX5 |
Pathways in cancer | FGF22;GSK3B;AXIN2;LAMC1;PLCB3;KRAS;RASSF1;ARHGEF12;SMAD4 |
Small cell lung cancer | LAMB4;LAMA2;LAMB3;APAF1;PIK3CG;PIK3R3;ITGA2;ITGA3;NFKBIA |
BIRC7 has several biochemical functions, for example, cysteine-type endopeptidase inhibitor activity, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BIRC7 itself. We selected most functions BIRC7 had, and list some proteins which have the same functions with BIRC7. You can find most of the proteins on our site.
Function | Related Protein |
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cysteine-type endopeptidase inhibitor activity | NGP;BIRC5B;PTTG1;STFA2;CST5;CST9;CARD17;AHSG2;AHSG |
cysteine-type endopeptidase inhibitor activity involved in apoptotic process | LEF1;XIAP;NOL3;VIL1;PRDX5;IGF1RA;MT3;AVP;BIRC7 |
enzyme binding | SUPT5H;MAP2K7;SLPI;DDC;ATP6AP2;TBP;UGT1A3;WWOX;CSF3 |
ligase activity | CBLB;PIAS1;CBLL1;TRIM56;UBR3;SMURF1;MARCH6;TRIML2;MARCH11 |
protein binding | PEX3;CETN2;HOXA10;TRMT112;SERP2;TBC1D9B;BRSK1;COMMD2;EIF4E2 |
ubiquitin-protein transferase activity | CMTM2A;NLRC4;HECW2;RNF144AA;HERC2;RNF20;PARK2;BARD1;RNF181 |
zinc ion binding | ZDHHC11;MMP19;LTA4H;IDE;ADH8B;ADH4;TRIM8;TRIM24;ADH1B |
BIRC7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BIRC7 here. Most of them are supplied by our site. Hope this information will be useful for your research of BIRC7.
CASP9; DIABLO; POLR1C; PHF1
- Q&As
- Reviews
Q&As (6)
Ask a questionIn response to the role of BIRC7 in cancer, some therapeutics can be developed, such as inhibitors or antibodies targeting BIRC7, which are used to inhibit the proliferation and survival of tumor cells and enhance the attack ability of the immune system.
It has complex associations with other genes and may interact with multiple genes to participate in biochemical processes such as apoptosis.
The types of mutations in BIRC7 include point mutations, insertions/deletions, duplications, etc., which may cause structural and functional abnormalities of the protein.
BIRC7 has a dual role in cancer, on the one hand, it can promote the proliferation and survival of tumor cells, and on the other hand, it can also suppress the immune response and help tumor cells evade the attack of the immune system.
Studying the regulatory mechanism of BIRC7 requires a comprehensive use of various experimental methods and techniques, such as gene knockout, transcriptome analysis, and protein-protein interactions.
By detecting the expression pattern of BIRC7, it can assist in the diagnosis of certain diseases, such as cancer, neurodegenerative diseases, etc.
Customer Reviews (3)
Write a reviewHigh solubility, fast dissolution, good adaptability to solvents.
BIRC7 has performed well in various experiments and is a reliable choice.
Very suitable for biological activity experiment, good activity.
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