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BLK

  • Official Full Name

    B lymphoid tyrosine kinase

  • Overview

    This gene encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates insulin synthesis and secretion in response to glucose and enhances the expression of several pancreatic beta-cell transcription factors.
  • Synonyms

    BLK; B lymphoid tyrosine kinase; tyrosine-protein kinase Blk; MGC10442; p55-Blk; b lymphocyte kinase; BLK nonreceptor tyrosine kinase; MODY11;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Human
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • Hi-5 Inscet Cell
  • Hi-5 Insect Cell
  • In Vitro Cell Free System
  • Insect (sf21)
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Sf21
  • Sf9 Insect Cell
  • Wheat Germ
  • C
  • His
  • GST
  • GST|His
  • His (Fc)
  • Avi
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human BLK-461H Active Recombinant Human BLK, GST-tagged Sf9 Insect Cell GST
Human BLK-1366H Active Recombinant Human BLK, GST-tagged Sf9 Insect Cell GST Full length
Human BLK-238H Active Recombinant Human BLK Protein, GST-His-tagged Sf9 Insect Cell GST/His
Human BLK-25HFL Active Recombinant Full Length Human BLK Protein, N-His-tagged Sf21 His Full Length
Human BLK-5368H Recombinant Human B Lymphoid Tyrosine Kinase, His-tagged Insect Cell His
Human BLK-26112TH Recombinant Human BLK, His-tagged Hi-5 Inscet Cell His 505 amino acids
Human BLK-239H Recombinant Human BLK Protein, GST-His-tagged Wheat Germ GST
Human BLK-240H Recombinant Human BLK Protein, GST-His-tagged Wheat Germ GST
Human BLK-770H Recombinant Human BLK Protein, His-tagged E.coli His
Human BLK-250H Recombinant Human B lymphoid Tyrosine Kinase, GST-tagged, Active Sf9 Insect Cell GST
Human BLK-642H Recombinant Human B Lymphoid Tyrosine Kinase E.coli N/A
Human BLK-1345H Recombinant Human B Lymphoid Tyrosine Kinase, His-tagged Hi-5 Insect Cell His 1-505aa
Human BLK-953H Active Recombinant Human BLK protein, GST-tagged Insect Cells GST Met1-Pro505
Human BLK-10238H Recombinant Human BLK, GST-tagged E.coli GST 1-100a.a.
Human BLK-614HCL Recombinant Human BLK cell lysate Insect Cell N/A
Human BLK-01H Recombinant Human BLK Protein, His-tagged E.coli His
Human BLK-8736HF Active Recombinant Full Length Human BLK Protein, GST-tagged Insect (sf21) GST 1-505(end)
Human BLK-0746H Recombinant Human BLK Protein (G2-P505), GST tagged Insect Cell GST G2-P505
Human BLK-1647HF Recombinant Full Length Human BLK Protein, GST-tagged In Vitro Cell Free System GST 505 amino acids
Human BLK-0745H Recombinant Human BLK Protein (G2-P505), Tag Free Insect Cell No tag G2-P505
Human BLK-1514H Recombinant Human BLK Protein (Leu241-Tyr494), N-His tagged E.coli N-His Leu241-Tyr494
Human BLK-1596H Recombinant Human BLK Protein (Gly2-Pro505), C-His tagged E.coli C-His Gly2-Pro505
Mouse BLK-26MFL Active Recombinant Full Length Mouse BLK Protein, N-His-tagged Sf21 His Full Length
Mouse BLK-2414M Recombinant Mouse BLK Protein Mammalian Cell His
Mouse BLK-1039M Recombinant Mouse BLK Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse BLK-1039M-B Recombinant Mouse BLK Protein Pre-coupled Magnetic Beads HEK293
Zebrafish BLK-3316Z Recombinant Zebrafish BLK Mammalian Cell His
Kit-1565 BLK Kinase Binding Assay Kit N/A
Kit-1566 BLK Activity Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • BLK Related Articles
  • BLK Related Research Area

BLK involved in several pathways and played different roles in them. We selected most pathways BLK participated on our site, such as Adaptive Immune System, Alpha-synuclein signaling, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers, which may be useful for your reference. Also, other proteins which involved in the same pathway with BLK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adaptive Immune SystemPIK3AP1;RASGRP2;HCST;AF251705;CTSC;RNF123;NRG3;FAM49BA;TREM1
Alpha-synuclein signalingBLK;TOR1A;KLK6;PARK7;STUB1;FKBP1A;CSNK2A1
Antigen activates B Cell Receptor (BCR) leading to generation of second messengersIGHM;STIM1B;BLK;PIK3AP1;AHCYL1;SRMS;AKR1C1;IGKV1-5;IGKC
Apoptosis Modulation and SignalingBLK;DFFA;BOK;CDKN2A;DAXX;CRADD;PTRH2;BCL2L10;SEPT4
B Cell Receptor Signaling PathwayPLEKHA2;MAPK3;MALT1;CMTM3;FCGR2B;RAC3;MAPK4;CTNNB2;CD19
CXCR4-mediated signaling eventsBLK;ARR3;PAG1;DNM1;CSK;MAPKAP1;JAK2;GNA13;GNB2L1
Class I PI3K signaling eventsADAP1;BLK;PLEKHA1;ITK;ARF1
EPHA forward signalingEFNA1;EFNA3;CRKL;EPHA2;EFNA2;EFNA5;ARHGEF15;BLK

BLK has several biochemical functions, for example, ATP binding, non-membrane spanning protein tyrosine kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BLK itself. We selected most functions BLK had, and list some proteins which have the same functions with BLK. You can find most of the proteins on our site.

Function Related Protein
ATP bindingMOS;CMPK1;ATP6V1BA;CDC42BPA;YARS;MAP3K13;EPHA6;CERK;FLT4
non-membrane spanning protein tyrosine kinase activityEIF2AK2;ITK;TEC;ABL2;ZNF143B;BMX;TNK1;PKDCC;JAK2B
protein bindingMGST1;STARD13;TGOLN2;GRIN2C;CASR;G3BP2;ANKRD1;AKAP17A;ING4
protein tyrosine kinase activityEPHA2A;FGFR2;NTRK2B;TNK2;KITA;PTK6B;FER;ABL2;FYN
receptor bindingRARA;HILPDA;GLA;LIF;FYNA;NRG1;HCST;IFNL3;TENM2

BLK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BLK here. Most of them are supplied by our site. Hope this information will be useful for your research of BLK.

EGFR; 80125; STAT3; EFS; saicar; ERBB2; MET; AR; KIT

Carmona, FD; Martin, J; et al. Genetics of vasculitis. CURRENT OPINION IN RHEUMATOLOGY 27:10-17(2015).
Sugiura, T; Kawaguchi, Y; et al. Association between a C8orf13-BLK Polymorphism and Polymyositis/Dermatomyositis in the Japanese Population: An Additive Effect with STAT4 on Disease Susceptibility. PLOS ONE 9:-(2014).
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