BMP8B
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Official Full Name
bone morphogenetic protein 8b
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Overview
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has led to speculation of possible bone inductive activity. -
Synonyms
BMP8B; bone morphogenetic protein 8b; BMP8, bone morphogenetic protein 8 (osteogenic protein 2); OP 2; osteogenic protein 2; BMP-8; BMP-8B; BMP8B_HUMAN; Bone morphogenetic protein 8; OP-2; OP2; OTTHUMP00000010836; bone morphogenetic protein 8 (osteogenic protein 2); dJ118J21.1 (bone morphogenetic protein 8 (osteogenic protein 2)); BMP8;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- CHO
- E. coli
- E.coli
- HEK293
- Mammalian Cell
- Wheat Germ
- His
- His (Fc)
- Avi
- His(N
- ter)
- His|SUMO
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- BMP8B Related Gene Family
- BMP8B Related Research Area
BMP8B involved in several pathways and played different roles in them. We selected most pathways BMP8B participated on our site, such as TGF-beta signaling pathway, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BMP8B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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TGF-beta signaling pathway | ACVR2A;NODAL;ID3;TGFB1;SMAD7;TFDP1;SMAD4;TGFBR1A;SMAD9 |
Hippo signaling pathway | FZD7;ACTG1;FZD9;APC;Fzd4;SAV1;PRKCZ;LLGL1;PPP2CB |
BMP8B has several biochemical functions, for example, BMP receptor binding, cytokine activity, growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BMP8B itself. We selected most functions BMP8B had, and list some proteins which have the same functions with BMP8B. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
BMP receptor binding | BMP8A;BMP2;BMP5;BMP7A;BMP8B;BMP3;BMP4;BMP6;BMP7B |
cytokine activity | GREM2;FLT3LG;IL17A/F2;CCL4;IL17A/F1;CXCL9;CMTM3;TNFSF4;CCL6 |
growth factor activity | TGFA;THPO;CXCL12;PDGFAB;DKK1;IL10;FGF11;FGF11A;JAG1 |
transforming growth factor beta receptor binding | GDF9;INHBAA;GDF1;NODAL;GDF10B;MSTN;GDF2;GDF3;GDF5 |
BMP8B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BMP8B here. Most of them are supplied by our site. Hope this information will be useful for your research of BMP8B.
WFIKKN2; WFIKKN1; ABL1; FYN
- Q&As
- Reviews
Q&As (5)
Ask a questionResearch suggests that BMP8B could be a potential target for obesity treatment due to its involvement in metabolic regulation, but more studies are needed to fully understand its therapeutic potential.
BMP8B has been implicated in cardiovascular health, with studies suggesting its involvement in vascular smooth muscle cell function and potential implications for cardiovascular diseases.
The role of BMP8B in cancer is still under investigation. Some studies suggest it may influence cancer cell behavior, but the exact mechanisms are not fully understood.
The potential side effects of manipulating BMP8B levels are not yet fully elucidated, and this is an area of active research.
BMP8B has been associated with female fertility, and studies indicate its involvement in the regulation of ovulation and the menstrual cycle.
Customer Reviews (3)
Write a reviewThe knowledgeable and responsive support team is dedicated to resolving issues and providing solutions that are tailored to specific experimental requirements.
This enables researchers to confidently incorporate BMP8B into their studies, knowing that they have access to a reliable and well-characterized protein that will contribute to robust and accurate results.
the high-quality BMP8B protein is available in various forms, including recombinant proteins and purified samples, enabling researchers to select the most suitable format for their specific experimental setup.
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