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BOP1

  • Official Full Name

    block of proliferation 1

  • Overview

    Ribosome biogenesis protein BOP1 is a protein that in humans is encoded by the BOP1 gene.It is a WD40 repeat-containing nucleolar protein involved in rRNA processing, thereby controlling the cell cycle.It is required for the maturation of the 25S and 5.8S ribosomal RNAs. It may serve as an essential factor in ribosome formation that coordinates processing of the spacer regions in pre-rRNA. The Pes1-Bop1 complex has several components: BOP1, GRWD1, PES1, ORC6L, and RPL3 and is involved in ribosome biogenesis and altered chromosome segregation. The overexpression of BOP1 increases the percentage of multipolar spindles in human cells. Deregulation of the BOP1 pathway may contribute to colorectal tumourigenesis in humans.Elevated levels of Bop1 induces Bop1/WDR12 and Bop1/Pes1 subcomplexes and the assembly and integrity of the PeBoW complex is highly sensitive to changes in Bop1 protein levels.
  • Synonyms

    BOP1; block of proliferation 1; ribosome biogenesis protein BOP1; KIAA0124; AU020183; AW146150; Block of proliferation 1 protein; Bop1 block of proliferation 1; BOP1_HUMAN; D18861; Erb1p; MGC109114; mKIAA0124; OTTHUMP00000228465;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human BOP1-308H Recombinant Human BOP1 Protein, GST-tagged Wheat Germ GST
Human BOP1-8418HCL Recombinant Human BOP1 293 Cell Lysate HEK293 N/A
Human BOP1-2772H Recombinant Human BOP1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human BOP1-3768HF Recombinant Full Length Human BOP1 Protein, GST-tagged In Vitro Cell Free System GST 746 amino acids
Mouse BOP1-2457M Recombinant Mouse BOP1 Protein Mammalian Cell His
Mouse BOP1-1068M-B Recombinant Mouse BOP1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Bop1-719M Recombinant Mouse Bop1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse BOP1-1068M Recombinant Mouse BOP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat BOP1-1003R Recombinant Rat BOP1 Protein Mammalian Cell His
Rat BOP1-661R-B Recombinant Rat BOP1 Protein Pre-coupled Magnetic Beads HEK293
Rat BOP1-661R Recombinant Rat BOP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish BOP1-4829Z Recombinant Zebrafish BOP1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

BOP1 involved in several pathways and played different roles in them. We selected most pathways BOP1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with BOP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

BOP1 has several biochemical functions, for example, poly(A) RNA binding, protein binding, ribonucleoprotein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BOP1 itself. We selected most functions BOP1 had, and list some proteins which have the same functions with BOP1. You can find most of the proteins on our site.

Function Related Protein
poly(A) RNA bindingEBI3;EIF4A2;XRN1;DHX57;CDKN2A;TOP3B;DDX50;TMSB4X;CCBL2
protein bindingZNF624;GPBP1;CUL1;PPP1R12C;TBC1D15;VPS24;SNX1;KLHL6;PPIF
ribonucleoprotein complex bindingPRPF31;PIGC;SECISBP2;PES1;WDR12;PES;CKAP5;BOP1;UHMK1

BOP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BOP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BOP1.

PES1; WDR12; b4dyc6_human; ARRB2; ARRB1; WDR48; NUDC; KLF10; NPM1; MNDA; IFI16; PELP1; WDR18; SENP3

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