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BPTF

Official Full Name

bromodomain PHD finger transcription factor
Overview

This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimers disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription. Two alternative transcripts encoding different isoforms have been described completely.
Synonyms

BPTF; bromodomain PHD finger transcription factor; FALZ, fetal Alzheimer antigen; nucleosome-remodeling factor subunit BPTF; FAC1; NURF301; fetal Alzheimer antigen; fetal Alz-50 clone 1 protein; fetal Alz-50 reactive clone 1; nucleosome remodeling factor;

Type

Recombinant Proteins

Species

Human

Source

E. coli
E.coli

Tag

C
His
GST
His|Flag
N
No tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	BPTF-156H	Recombinant Human BPTF, GST-tagged	E.coli	GST		Inquiry
Human	BPTF-80H	Recombinant Human BPTF protein, GST-tagged	E.coli	GST	2791-2920	Inquiry
Human	BPTF-33H	Recombinant Human BPTF, His&FLAG-tagged	E.coli	His/Flag		Inquiry
Human	BPTF-14H	Recombinant Human BPTF Protein, GST-tagged	E.coli	GST		Inquiry
Human	BPTF-81H	Recombinant Human BPTF protein, His-tagged	E.coli	His	2791-2920	Inquiry
Human	BPTF-82H	Recombinant Human BPTF protein, GST-tagged	E.coli	GST	2722-2920	Inquiry
Human	BPTF-83H	Recombinant Human BPTF protein, His-tagged	E.coli	His	2722-2920	Inquiry
Human	BPTF-1017H	Recombinant Human BPTF Protein (D2865-A3033), Tag Free	E.coli	No tag	D2865-A3033	Inquiry
Human	BPTF-21H	Recombinant Human BPTF protein(361-880 aa), His-tagged	E. coli	C-His	361-880 aa	Inquiry
Human	BPTF-1018H	Recombinant Human BPTF Protein (D2865-A3033), His tagged	E.coli	His	D2865-A3033	Inquiry
Human	BPTF-20H	Recombinant Human BPTF protein(459-657 aa), GST-tagged	E. coli	N-GST	459-657 aa	Inquiry

Involved Pathway
Protein Function
Interacting Protein

BPTF involved in several pathways and played different roles in them. We selected most pathways BPTF participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with BPTF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

BPTF has several biochemical functions, for example, contributes_to DNA-dependent ATPase activity, protein binding, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BPTF itself. We selected most functions BPTF had, and list some proteins which have the same functions with BPTF. You can find most of the proteins on our site.

Function	Related Protein
contributes_to DNA-dependent ATPase activity	GTF2H3;BPTF;RBBP4;ERCC2;ERCC3;GTF2H2;GTF2H1;GTF2H4;MNAT1
protein binding	C9orf78;LSM7;KIF27;SNIP1;CDK5R2;SH3PXD2B;GAP43;DNTTIP1;Akap3
sequence-specific DNA binding	LHX2;NKX2.1;HOXD12A;ISL2B;IRX7;SIX2B;TCF7;TCF7L1B;LHX1
transcription factor binding	HEY1;DDX3X;SUFU;CEBPB;HMGA1-RS1;DOT1L;TRIB2;RBL1;MSX2
zinc ion binding	ZNRF2B;MT1B;RARA;TRIM17;ADAMTS5;PEX12;PRICKLE1B;TMEM163;ADAM5P

BPTF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BPTF here. Most of them are supplied by our site. Hope this information will be useful for your research of BPTF.

ms-417; HIST2H4B; H3F3A; SQSTM1; h3_peptide_2-18; hxa9_human_gene; CBX6; MYC