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BRCA1

  • Official Full Name

    breast cancer 1, early onset

  • Overview

    Breast Cancer Gene 1 (BRCA1) is phosphorylated at Ser1524, and occurs in response to ionizing and ultraviolet radiation.
  • Synonyms

    BRCA1; breast cancer 1, early onset; breast cancer type 1 susceptibility protein; BRCA1/BRCA2 containing complex; subunit 1; BRCC1; PPP1R53; protein phosphatase 1; regulatory subunit 53; RNF53; RING finger protein 53; BRCA1/BRCA2-containing complex, subunit 1; protein phosphatase 1, regulatory subunit 53; breast and ovarian cancer susceptibility protein 1; breast and ovarian cancer sususceptibility protein 1; IRIS; PSCP; BRCAI; PNCA4; BROVCA1;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Sf21 Insect Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human BRCA1-8497H Active Recombinant Human BRCA1, His-tagged Sf21 Insect Cell His
Human BRCA1-1018H Active Recombinant Human Breast Cancer 1, Early Onset Sf9 Insect Cell N/A
Human BRCA1-10279H Recombinant Human BRCA1, GST-tagged E.coli GST C-term-350a.a.
Human BRCA1-42H Recombinant Human BRCA1 protein, GST-tagged E.coli GST
Human BRCA1-6881H Recombinant Human BRCA1 protein, His-tagged E.coli His Gln19~Val83 (Accession # P38398)
Human BRCA1-325H Recombinant Human BRCA1 Protein, GST-tagged Wheat Germ GST
Human BRCA1-0793H Recombinant Human BRCA1 Protein (Gln19-Val83), His tagged E.coli His Gln19-Val83
Human BRCA1-5256H Recombinant Human BRCA1 protein, His-tagged E.coli His 24-255aa
Human BRCA1-3782HF Recombinant Full Length Human BRCA1 Protein, GST-tagged In Vitro Cell Free System GST 59 amino acids
Human BRCA1-21H Recombinant Human BRCA1 Protein (BRCT domains), N-GST tagged E.coli N-GST
Mouse Brca1-6882M Recombinant Mouse Brca1 protein, His & T7-tagged E.coli His/T7 Phe1524~Leu1781 (Accession # P48754)
Mouse BRCA1-2479M Recombinant Mouse BRCA1 Protein Mammalian Cell His
Mouse BRCA1-1083M-B Recombinant Mouse BRCA1 Protein Pre-coupled Magnetic Beads HEK293
Mouse BRCA1-1083M Recombinant Mouse BRCA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Brca1-6883R Recombinant Rat Brca1 protein, His & GST-tagged E.coli His/GST Ser1579~Glu1811 (Accession # O54952)
Rat BRCA1-1010R Recombinant Rat BRCA1 Protein Mammalian Cell His
Rat BRCA1-668R Recombinant Rat BRCA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat BRCA1-668R-B Recombinant Rat BRCA1 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey BRCA1-349C Recombinant Cynomolgus BRCA1 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey BRCA1-97C-B Recombinant Cynomolgus Monkey BRCA1 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey BRCA1-97C Recombinant Cynomolgus Monkey BRCA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque BRCA1-562R Recombinant Rhesus monkey BRCA1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque BRCA1-390R-B Recombinant Rhesus Macaque BRCA1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque BRCA1-390R Recombinant Rhesus Macaque BRCA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken BRCA1-5743C Recombinant Chicken BRCA1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • BRCA1 Related Articles
  • BRCA1 Related Research Area

BRCA1 involved in several pathways and played different roles in them. We selected most pathways BRCA1 participated on our site, such as Fanconi anemia pathway, Ubiquitin mediated proteolysis, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BRCA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Fanconi anemia pathwayFUZ;MLH1;POLN;POLH;C19orf40;ZBTB32;SLX4;CDK5R2;ATRIP
Ubiquitin mediated proteolysisCOP1;WWP2;UBE2I;UBA1;SIAH2L;CUL4B;UBE2Q1;CUL5;SKP2
PIK-Akt signaling pathwayTCL1;MAP2K2;LPAR2;FGFR1;EIF4E2;PPP2R5B;COL6A5;THBS3;IRS1
MicroRNAs in cancerRAF1;TNN;DNMT1;VIM;ZFPM2;CD44;NOTCH4;MET;SOS1

BRCA1 has several biochemical functions, for example, DNA binding, RNA binding, androgen receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BRCA1 itself. We selected most functions BRCA1 had, and list some proteins which have the same functions with BRCA1. You can find most of the proteins on our site.

Function Related Protein
DNA bindingFOXQ1A;ZFAND5;FLYWCH1;MCM6L;ZFP82;FOXJ1;JUN;ARNTL1A;RNF6
RNA bindingCTU1;TUT1;RBM39B;BARHL1;DHX36;PUS10;KHDRBS1B;RPL3;FXR1
androgen receptor bindingWIPI1;CALR;Ar;KDM1A;PRPF6;RB1;PIAS1;TGFB1I1;RNF4
damaged DNA bindingPOLK;RAD18;POLB;TP73;RPA3;POLI;XPC;RPA2;TRP53
enzyme bindingITGB3;HIST1H2AN;HIST1H2AM;HDAC10;CAV1;PHB;P4HB;PTPLA;RPA3
ligase activityARIH1L;RNF34;ACSF2;TTLL5;RANBP2;RNF115;RNF43;TRIM24;RING1
protein bindingPOU4F1;PAX5;EIF4G1;OGFR;CISH;ATP1A1;SETD7;CXCL9;NOL6
transcription coactivator activityMTF1;MED7;DDX17;ING4;NR2F1;TRIM32;NR1I2;BCL10;CTBP2
transcription regulatory region DNA bindingHNF1A;BCOR;KLF17;ZFP335;ARID4A;ARID5A;ZNF831;KLF2A;KCNA3
tubulin bindingAGBL4;TTLL4;STMN1;TPR;TBCC;STMN3;TTLL6;EML2;EML1
ubiquitin protein ligase bindingHSPA1A;RPA2;CDC34A;HSPA8;UBOX5;SUMO2;SMC6;CHEK2;HIF1A
ubiquitin-protein transferase activityZER1;RNF146;UBR5;UBE2S;RNF139;RNF43;RNF141;SHPRH;TRAF7
zinc ion bindingGDA;CA5A;KMT2E;INTS12;MMP8;TRIM37;RNPEP;TRIM40;RNF130

BRCA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BRCA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BRCA1.

BRIP1; BARD1

Seksenyan, A; Kadavallore, A; et al. TOX3 is expressed in mammary ER+ epithelial cells and regulates ER target genes in luminal breast cancer. BMC CANCER 15:-(2015).
Kast, K; Rhiem, K; et al. Familial Breast Cancer - Targeted Therapy in Secondary and Tertiary Prevention. BREAST CARE 10:27-31(2015).
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