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BRF1

Official Full Name

BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
Overview

This gene encodes one of the three subunits of the RNA polymerase III transcription factor complex. This complex plays a central role in transcription initiation by RNA polymerase III on genes encoding tRNA, 5S rRNA, and other small structural RNAs. The gene product belongs to the TF2B family. Several alternatively spliced variants encoding different isoforms, that function at different promoters transcribed by RNA polymerase III, have been identified. [provided by RefSeq, Jun 2011]
Synonyms

BRF1; BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit; BRF; hBRF; BRF-1; GTF3B; TAF3C; TAF3B2; TF3B90; TAFIII90; TFIIIB90; HEL-S-76p; transcription factor IIIB 90 kDa subunit; B - related factor 1; general transcription factor IIIB, 90kD subunit; TBP - associated factor, RNA polymerase III, 90kD; epididymis secretory sperm binding protein Li 76p; TATA box binding protein (TBP)-associated factor 3C; BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB; TATA box binding protein (TBP)-associated factor, RNA polymerase III, GTF3B subunit 2;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Human
Mouse

Source

HEK293
HEK293T
In Vitro Cell Free System
Wheat Germ
Yeast

Tag

GST
His
Myc
DDK
Myc|DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	BRF1-336H	Recombinant Human BRF1 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	BRF1-180HCL	Recombinant Human BRF1 cell lysate		N/A		Inquiry
Human	BRF1-5844H	Recombinant Human BRF1 protein, His-tagged	Yeast	His	1-677aa	Inquiry
Human	BRF1-2791H	Recombinant Human BRF1 Protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Human	BRF1-3794HF	Recombinant Full Length Human BRF1 Protein, GST-tagged	In Vitro Cell Free System	GST	208 amino acids	Inquiry
Mouse	Brf1-1892M	Recombinant Mouse Brf1 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry

Involved Pathway
Protein Function
Interacting Protein

BRF1 involved in several pathways and played different roles in them. We selected most pathways BRF1 participated on our site, such as Gene Expression, Integrated Pancreatic Cancer Pathway, RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription, which may be useful for your reference. Also, other proteins which involved in the same pathway with BRF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Gene Expression	ZNF740;RBB4L;ZNF212;ELL;SMARCA5;TTC6;ZNF614;ZNF705A;MTA2
Integrated Pancreatic Cancer Pathway	JUND;RAPGEF3;IL11;CD82;MYT1;DAXX;RB1CC1;TOP1;FST
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription	CHD4A;POU2F1;SNAPC1A;TFB2M;NFIC;ZFP143;SNAPC5;CHD4;NFIA
RNA Polymerase III Abortive And Retractive Initiation	POU2F1;NFIB;GTF3C3;SNAPC3;NFIA;NFIX;NFIC;SNAPC5;BRF2
RNA Polymerase III Transcription	NFIB;SNAPC1A;GTF3AA;SNAPC2;ZNF143A;ZNF143;GTF3C5;SNAPC4;NFIX
RNA Polymerase III Transcription Initiation	GTF3A;GTF3C2;GTF3C5;ZNF143B;GTF3AB;SNAPC5;GTF3C4;SNAPC4;SNAPC1A
RNA Polymerase III Transcription Initiation From Type 1 Promoter	GTF3C3;GTF3AA;GTF3A;GTF3AB;POLR3GLA;GTF3C2;GTF3C5;BRF1;BRF1B
RNA Polymerase III Transcription Initiation From Type 2 Promoter	GTF3C5;BRF1B;BRF1;GTF3C4;GTF3C3;GTF3C2

BRF1 has several biochemical functions, for example, TBP-class protein binding, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BRF1 itself. We selected most functions BRF1 had, and list some proteins which have the same functions with BRF1. You can find most of the proteins on our site.

Function	Related Protein
TBP-class protein binding	TAF1B;BRF1A;PSMC5;TAF1;EFCAB11;CAND1;BRF1B;PSMC6;BRF1
zinc ion binding	ZCCHC12;TRIM6;RBM4B;RAI1;BRF2;LONRF2;KLF7;UBR3;CRIP3

BRF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BRF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BRF1.

TBP; DTNBP1; ACSL4; Eef1a1; Rab5c; Vbp1; Gpsm1; CCDC132; POLR3E; TCF20