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BRWD1

Official Full Name

bromodomain and WD repeat domain containing 1
Overview

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) residues which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 2 bromodomains and multiple WD repeats. This gene is located within the Down syndrome region-2 on chromosome 21. Alternative splicing of this gene generates multiple transcript variants encoding distinct isoforms. In mouse, this gene encodes a nuclear protein that has a polyglutamine-containing region that functions as a transcriptional activation domain which may regulate chromatin remodelling and associates with a component of the SWI/SNF chromatin remodelling complex.
Synonyms

BRWD1; bromodomain and WD repeat domain containing 1; C21orf107, chromosome 21 open reading frame 107 , WD repeat domain 9 , WDR9; bromodomain and WD repeat-containing protein 1; FLJ11315; N143; Bromodomain and WD repeat domain containing protein 1; BRWD1_HUMAN; C21orf107; cAMP response element binding and beta tranducin family; chromosome 21 open reading frame 107; Response element binding and beta tranducin family like; Transcriptional unit N143; WD repeat protein; WD repeat protein WDR9 form2; WD repeat-containing protein 9; WDR9; WD repeat protein WDR9-form2;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Human

Source

E.coli
In Vitro Cell Free System
Wheat Germ

Tag

GST
His
His|Flag
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	BRWD1-62H	Recombinant Human BRWD1 protein, GST-tagged	E.coli	GST	1310-1430	Inquiry
Human	BRWD1-167H	Recombinant Human BRWD1, GST-tagged	E.coli	GST		Inquiry
Human	BRWD1-38H	Recombinant Human BRWD1, His&FLAG-tagged	E.coli	His/Flag		Inquiry
Human	BRWD1-63H	Recombinant Human BRWD1 protein, His-tagged	E.coli	His	1310-1430	Inquiry
Human	BRWD1-355H	Recombinant Human BRWD1 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	BRWD1-186HCL	Recombinant Human BRWD1 cell lysate		N/A		Inquiry
Human	BRWD1-3823HF	Recombinant Full Length Human BRWD1 Protein, GST-tagged	In Vitro Cell Free System	GST	120 amino acids	Inquiry

Involved Pathway
Protein Function
Interacting Protein

BRWD1 involved in several pathways and played different roles in them. We selected most pathways BRWD1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with BRWD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

BRWD1 has several biochemical functions, for example, molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by BRWD1 itself. We selected most functions BRWD1 had, and list some proteins which have the same functions with BRWD1. You can find most of the proteins on our site.

Function	Related Protein
molecular_function	ABI2A;GM806;KRTAP6-5;IFI27L2B;CCDC11;HIST2H2AA4;DCST1;IQCJ;ZBBX

BRWD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BRWD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BRWD1.

mutT7; UBXN7; CBX6; MYC; Lin28a; MMGT1