BMPR1A
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Official Full Name
bone morphogenetic protein receptor, type IA
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Overview
The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. -
Synonyms
BMPR1A; bone morphogenetic protein receptor, type IA; ACVRLK3; bone morphogenetic protein receptor type-1A; ALK3; CD292; ALK-3; BMPR-1A; BMP type-1A receptor; activin receptor-like kinase 3; activin A receptor, type II-like kinase 3; serine/threonine-prot;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Canine
- Chicken
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Rat
- Rhesus Macaque
- Rhesus monkey
- CHO cells
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- Human
- Human Cell
- Human Cells
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Sf21 Insect Cell
- Sf9 Insect Cell
- Wheat Germ
- C
- Fc
- His
- hFc
- Fc Chimera
- Fc|His
- GST
- hIgG1
- hIgG4
- His (Fc)
- Avi
- His|HIgG
- His|SUMO
- His|T7
- human|IgG1|Fc
- MYC
- DDK
- Myc|DDK
- N/A
- N
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- BMPR1A Related Gene Family
- BMPR1A Related Research Area
BMPR1A involved in several pathways and played different roles in them. We selected most pathways BMPR1A participated on our site, such as Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BMPR1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Cytokine-cytokine receptor interaction | IL20;CCL16;TNFRSF6B;GM2506;IL6ST;CXCL12A;CXCR4A;CCL25;CXCL12 |
TGF-beta signaling pathway | ID2;ACVR2AA;NOG3;ZFYVE16;RPS6KB1B;FSTA;TGFBR1A;ID3;SKP1 |
Hippo signaling pathway | WNT7B;TEAD1;PPP2R2D;NF2;CRB2;WNT9B;DLG1;GDF5;FBXW11 |
Signaling pathways regulating pluripotency of stem cells | POU5F1;ACVR1B;TBX3;BMPR1B;FGFR1;KRAS;ACVR1;WNT11;GSK3B |
BMPR1A has several biochemical functions, for example, ATP binding, RNA polymerase II transcription factor activity, sequence-specific DNA binding, SMAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BMPR1A itself. We selected most functions BMPR1A had, and list some proteins which have the same functions with BMPR1A. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
ATP binding | ABCG2D;CDC7;PSKH1;DICER1;TARS2;ACTB;RPS6KB1B;ABCG5;PIK3C2A |
RNA polymerase II transcription factor activity, sequence-specific DNA binding | MKX;FOXA1;ZNF215;FOXC1B;FOXC1;FOXP1;FOXA;XBP1;FOXO3 |
SMAD binding | RNF111;MAGI2;YY1;FOXH1;COL1A2;TGFBRAP1;TGFBR3;SKOR1B;SKOR1 |
glycoprotein binding | CANX;EDEM2;ITGA3;SDCBP;Itgam&Itgb2;AZGP1;LGALS1;LCK;Serpina1b |
metal ion binding | ZNF485;ZNF781;ZFP804A;OVCH2;KEL;MICAL2B;ZNF330;OSR1;PDE10A |
protein binding | SPINK2;BCL2L2;WDTC1;RTP3;FZD8;MT3;TDRD9;PIP5K1C;C9orf78 |
protein homodimerization activity | UGT1A6A;PON1;MTHFD1L;CEACAM1;RAB11FIP4B;BIRC5;IL17F;ADAM10;RIPK2 |
protein serine/threonine kinase activity | MAP3K8;TAOK3;ALPK1;SMG1;CLK3;PRKCZ;ULK1A;ACVR1L;IRAK2 |
receptor signaling protein serine/threonine kinase activity | ACVR1C;BMPR1A;SLKA;NEK4;BMPR1AB;BMPR2B;BMPR1BB;ACVR2AA;TGFBR1A |
transmembrane receptor protein serine/threonine kinase activity | BMPR1BA;TGFBR1A;ACVR1L;TGFBR2;BMPR1BB;TGFBR1B;BMPR1B;BMPR1AA;BMPR2A |
BMPR1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BMPR1A here. Most of them are supplied by our site. Hope this information will be useful for your research of BMPR1A.
BMP2; GDF5; BMP4; BMP2; BMP2; FSTL1; HSP90AB1
- Q&As
- Reviews
Q&As (6)
Ask a questionAbnormal levels of BMPR1A may suggest skeletal dysplasia, tumors, etc., but its specificity and sensitivity need to be further studied.
The types of mutations in BMPR1A include point mutations, insertions/deletions, duplications, etc., which may cause structural and functional abnormalities of the protein.
Mutations in BMPR1A can be detected and analyzed by methods such as whole-genome sequencing or target region sequencing to understand the impact of mutations on protein structure and function.
Studying the regulatory mechanism of BMPR1A requires a comprehensive use of various experimental methods and techniques, such as gene knockout, transcriptome analysis, and protein-protein interactions.
BMPR1A can be used as a biomarker in medical treatment to help monitor disease progression and treatment efficacy. In addition, therapeutics targeting BMPR1A, such as gene therapy or modulating its expression, are also being studied.
Deficiency or abnormal expression of BMPR1A may be related to some skeletal dysplasia diseases, tumors, etc.
Customer Reviews (3)
Write a reviewThe enzyme activity of this protein reached the expected level and was able to play a role in the specific reaction.
When experimenting with this protein, stable and repeatable results can be obtained.
This product has strict quality control and complies with relevant industry standards.
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