C1QB
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Official Full Name
complement component 1, q subcomponent, B chain
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Overview
This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in;order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus;erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six;C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The;A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the B-chain polypeptide of;human complement subcomponent C1q. -
Synonyms
C1QB; complement component 1, q subcomponent, B chain; complement component 1, q subcomponent, beta polypeptide; complement C1q subcomponent subunit B; Complement component 1 q subcomponent B chain; Complement component 1 q subcomponent beta polypeptide; Complement component C1q B chain; Complement subcomponent C1q chain B; OTTHUMP00000002940; OTTHUMP00000002941; complement component C1q, B chain;
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- His
- His (Fc)
- Avi
- Myc
- DDK
- MYC
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- Involved Pathway
- Protein Function
- Interacting Protein
- C1QB Related Articles
- C1QB Related Research Area
C1QB involved in several pathways and played different roles in them. We selected most pathways C1QB participated on our site, such as Complement and coagulation cascades, Prion diseases, Pertussis, which may be useful for your reference. Also, other proteins which involved in the same pathway with C1QB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Complement and coagulation cascades | CFD;F5;C5AR1;Serpina1b;F12;C1S;SERPINF2;C4BP;PLAUR |
Prion diseases | C7;IL1A;C1QB;NOTCH1;FYN;IL1B;SOD1;ELK1;HSPA5 |
Pertussis | GNAI3;MAPK9;FOS;CASP7;Casp3;MAPK8;Hc;MAPK11;IRF8 |
Chagas disease (American trypanosomiasis) | PPP2R2A;PIK3CD;CCL5;ACE;IL12B;MAPK11;NOS2;TLR2;Fasl |
Staphylococcus aureus infection | HLA-DPA1;C5;FCGR2A;C5AR1;C1QC;ITGB2L;C1RA;HLA-DRA;HLA-DMA |
Systemic lupus erythematosus | GM14477;SNRPD3;HIST1H2AP;HLA-DRB4;FCGR4;HIST1H2AM;C2;H2AFX;HIST1H2AJ |
C1QB has several biochemical functions, for example, protein binding, protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by C1QB itself. We selected most functions C1QB had, and list some proteins which have the same functions with C1QB. You can find most of the proteins on our site.
Function | Related Protein |
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protein binding | GNB2L1;SRGAP1;DPYSL2;LCE3C;MPDU1;EDEM1;BFSP2;HOXA10;CANX |
protein homodimerization activity | CARS;EVLA;G6PD;TWIST1;TERF1;PON1;BOKB;MCL1A;NADK2 |
C1QB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with C1QB here. Most of them are supplied by our site. Hope this information will be useful for your research of C1QB.
C1QA; RELA; q7chk1_yerpe; sbcD; treC; q81sh2_bacan; EDA2R
- Q&As
- Reviews
Q&As (7)
Ask a questionC1QB, as part of C1q, plays a role in opsonization by marking pathogens and immune complexes for phagocytosis after binding and activating the complement system.
C1QB is one of the chains (together with C1QA and C1QC) that forms the C1q molecule, which is the first component of the classical pathway of the complement system, playing a crucial role in innate immunity.
Given the role of C1QB in the complement system and its association with autoimmune diseases, targeting C1QB or its interactions might be a therapeutic strategy for conditions like SLE or other complement-mediated diseases.
C1QB, as a part of the C1q molecule, plays a significant role in recognizing and binding to immune complexes, apoptotic cells, and certain pathogens, thereby activating the classical complement pathway and facilitating their clearance.
Once C1q (comprising C1QA, C1QB, and C1QC) binds to immune complexes, it triggers the binding and autoactivation of C1r and C1s serine proteases, forming the active C1 complex and initiating the classical complement cascade.
C1q is a hexamer formed by the association of six C1qA, six C1qB, and six C1qC chains. C1QB contributes to this hexameric structure, which is essential for the recognition of immune complexes.
Mutations in the C1QB gene can lead to C1q deficiency, which is associated with an increased risk of systemic lupus erythematosus (SLE) and other autoimmune diseases.
Customer Reviews (3)
Write a reviewProduct is worth the price.
Outstanding performance in experiments.
Excellent for biochemical assays.
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