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C1R

  • Official Full Name

    complement component 1, r subcomponent

  • Overview

    C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.
  • Synonyms

    C1R; complement component 1, r subcomponent; complement C1r subcomponent;

  • Recombinant Proteins
  • Native Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Normal human serum (shown by certified tests to be negative for HBsAg, HTLV-I/II, STS, and for antibodies to HCV, HIV-1 and HIV-II)
  • Wheat Germ
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human C1R-718H Active Recombinant Human C1R, His-tagged Mammalian cells His
Human C1R-96H Active Native Human C1r Enzyme Normal human serum (shown by certified tests to be negative for HBsAg, HTLV-I/II, STS, and for antibodies to HCV, HIV-1 and HIV-II) N/A
Human C1R-26129TH Recombinant Human C1R Wheat Germ N/A 705 amino acids
Human C1R-8133HCL Recombinant Human C1R 293 Cell Lysate HEK293 N/A
Human C1R-2666H Active Recombinant Human C1R protein, His-tagged HEK293 His Met1-Asp705
Human C1R-41HF Recombinant Full Length Human C1R Protein In Vitro Cell Free System 705 amino acids
Human C1R-2571H Recombinant Human C1R Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human C1R-2571H-B Recombinant Human C1R Protein Pre-coupled Magnetic Beads HEK293
Human C1R-0280H Recombinant Human C1R Protein (Ala356-Asp705), N-His-tagged E.coli N-His Ala356-Asp705
Zebrafish C1R-3265Z Recombinant Zebrafish C1R Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • C1R Related Articles
  • C1R Related Gene Family
  • C1R Related Research Area

C1R involved in several pathways and played different roles in them. We selected most pathways C1R participated on our site, such as Phagosome, Complement and coagulation cascades, Pertussis, which may be useful for your reference. Also, other proteins which involved in the same pathway with C1R were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PhagosomeITGB1;HLA-DQA2;NOX3;FCGR3A;ATP6V0A2;ATP6V1C1;TUBA1L2;C1R;ATP6V0D2
Complement and coagulation cascadesC8A;Serpina1b;C3AR1;MBL2;C2;Hc;THBD;LOC100514666;CR1L
PertussisCD14;IL6;TLR4;NLRP3;MAPK12;CALM4;NFKB1;Il23a; Il12b;GNAI3
Staphylococcus aureus infectionC1S;HLA-DPB1;HLA-DMA;DSG1C;FCGR3A;C5;ICAM1;HLA-DQA1;HLA-DRB3
Systemic lupus erythematosusTNF;HLA-DRB5;HIST1H3H;GM14478;HIST1H2AO;Hc;HLA-DMA;GM14479;FCGR1

C1R has several biochemical functions, for example, calcium ion binding, protein binding, serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by C1R itself. We selected most functions C1R had, and list some proteins which have the same functions with C1R. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingEGFL6;MYL2B;PCDHGB3;CAPN2;SPOCK2;PCDH10;CANX;PCDHGA10;PCDH1GC5
protein bindingBTN3A1;MAD1L1;NPEPL1;NGFRB;TTC6;ADAM10;DMC1;CCDC106;ACVR1B
serine-type endopeptidase activityGZMB;KEX2;LOC780933;GM5077;CELA3A;FURINA;FURINB;F9;TMPRSS11E
serine-type peptidase activityPRTN3;Gzmd;TMPRSS7;TRY;KLK15;F7;DPP7;C1R;HTRA1

C1R has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with C1R here. Most of them are supplied by our site. Hope this information will be useful for your research of C1R.

C1S; N/A; calcium(2+); PCK1; EP300; d-mannose

Keizer, MP; Pouw, RB; et al. TFPI inhibits lectin pathway of complement activation by direct interaction with MASP-2. EUROPEAN JOURNAL OF IMMUNOLOGY 45:544-550(2015).
Muia, J; Zhu, J; et al. Allosteric activation of ADAMTS13 by von Willebrand factor. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:18584-18589(2014).
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