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CACNA2D1

  • Official Full Name

    calcium channel, voltage-dependent, alpha 2/delta subunit 1

  • Overview

    This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
  • Synonyms

    CACNA2D1; calcium channel, voltage-dependent, alpha 2/delta subunit 1; CACNA2, CACNL2A, MHS3; voltage-dependent calcium channel subunit alpha-2/delta-1; calcium channel, L type, alpha 2 polypeptide; voltage-gated calcium channel subunit alpha-2/delta-1; d;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • E.coli
  • HEK293
  • Mammalian Cell
  • Yeast
  • GST
  • His
  • His (Fc)
  • Avi
  • His|SUMO
  • SUMO
  • Trx|His|SUMO
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CACNA2D1-29H Recombinant Human CACNA2D1 protein, Trx-His-SUMO-tagged E.coli Trx/His/SUMO 1315aa(including fusion tag)
Human CACNA2D1-161H Recombinant Human CACNA2D1 Mammalian Cell His
Human CACNA2D1-2301H Recombinant Human CACNA2D1 Protein (577-717 aa), His-tagged Yeast His 577-717 aa
Human CACNA2D1-3729H Recombinant Human CACNA2D1 protein, GST-tagged E.coli GST 25-124 aa
Human CACNA2D1-089H Recombinant Human CACNA2D1 protein, His-SUMO-tagged E.coli His-SUMO 528-668aa
Human CACNA2D1-2391H Recombinant Human CACNA2D1 Protein (528-668 aa), His-SUMO-tagged E.coli His/SUMO 528-668 aa
Human CACNA2D1-2619H Recombinant Human CACNA2D1 protein, His-SUMO-tagged E.coli His-SUMO 577-717aa
Human CACNA2D1-2579H Recombinant Human CACNA2D1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CACNA2D1-2579H-B Recombinant Human CACNA2D1 Protein Pre-coupled Magnetic Beads HEK293
Mouse CACNA2D1-2615M Recombinant Mouse CACNA2D1 Protein Mammalian Cell His
Mouse CACNA2D1-1170M Recombinant Mouse CACNA2D1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CACNA2D1-1170M-B Recombinant Mouse CACNA2D1 Protein Pre-coupled Magnetic Beads HEK293
Chicken CACNA2D1-4079C Recombinant Chicken CACNA2D1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

CACNA2D1 involved in several pathways and played different roles in them. We selected most pathways CACNA2D1 participated on our site, such as MAPK signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with CACNA2D1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayCASP3A;CACNG6A;ATF4B1;HSPA1L;PRKCB;TGFB1;CACNA1D;PTPN7;PLA2G4F
Cardiac muscle contractionCACNG1A;ATP1B2B;CACNB3;ATP1B4;COX8A;TNNC1;TPM2;CACNA1D;CACNG7A
Adrenergic signaling in cardiomyocytesPPP2R2BB;ATP1A1B;CACNB2A;PIK3CB;CACNG8;ATP1A3A;KCNQ1;ATP1B2A;ATF4B1
Oxytocin signaling pathwayCACNG8;MAP2K2;MAPK3;MYLK2;NFATC4;PTGS2;CACNG4;MYL6;RCAN1
Hypertrophic cardiomyopathy (HCM)ACTB;TGFB3;ACTC1;ITGA8;CACNA2D2;EMD;DAG1;CACNG4;CACNG8
Arrhythmogenic right ventricular cardiomyopathy (ARVC)JUP;DSC2;SLC8A1;ACTN3;DSP;ITGA10;CACNG8;CACNB4;ITGA4
Dilated cardiomyopathyITGB4;CACNA2D1;ITGB8;CACNA2D3;CACNB1;DAG1;ITGAV;PLN;ITGA1

CACNA2D1 has several biochemical functions, for example, calcium channel regulator activity, metal ion binding, voltage-gated calcium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CACNA2D1 itself. We selected most functions CACNA2D1 had, and list some proteins which have the same functions with CACNA2D1. You can find most of the proteins on our site.

Function Related Protein
calcium channel regulator activityNRXN1;SGK1;HPCAL4;CACNA2D3;NPY2R;GRM2;SRI;CACNB2;SGK2B
metal ion bindingPCGF5B;ZNF771;SPATA21;ZFP426;ESCO1;CXXC1B;CPXCR1;FYNA;ZBTB1
voltage-gated calcium channel activityTMC1;CACNG8;CACNB4A;NCS1;PKD2;CACNB2B;CATSPER1;GAS6;CALHM1
contributes_to voltage-gated calcium channel activityCACNB4;CACNA2D1;CACNB3

CACNA2D1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CACNA2D1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CACNA2D1.

Baz2b; MYH7B; Calu; Itgb1; Plk2; HNRNPU; Ccdc77; CNOT2

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