CACNB2
-
Official Full Name
calcium channel, voltage-dependent, beta 2 subunit
-
Overview
This gene encodes a subunit of a voltage-dependent calcium channel protein which is a member of the voltage-gated calcium channel superfamily. The gene product was originally identified as an antigen target in Lambert-Eaton myasthenic syndrome which is an autoimmune disorder. Mutations in this gene are associated with Brugada symdrome. Alternatively spliced variants have been identified for this gene. -
Synonyms
CACNB2; calcium channel, voltage-dependent, beta 2 subunit; CACNLB2, MYSB; voltage-dependent L-type calcium channel subunit beta-2; CAB2; lambert-Eaton myasthenic syndrome antigen B; myasthenic (Lambert-Eaton) syndrome antigen B; calcium channel voltage-d;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Rat
- Rhesus Macaque
- E.coli
- HEK293
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | CACNB2-26766TH | Recombinant Human CACNB2 | Wheat Germ | N/A | 89 amino acids |
|
| Human | CACNB2-10639H | Recombinant Human CACNB2, His-tagged | E.coli | His | C-term-184a.a. | |
| Human | CACNB2-332H | Recombinant Human CACNB2 Protein, His-tagged | E.coli | His |
|
|
| Human | CACNB2-0272H | Recombinant Human CACNB2 Protein, GST-Tagged | Wheat Germ | GST |
|
|
| Rat | CACNB2-1069R | Recombinant Rat CACNB2 Protein | Mammalian Cell | His |
|
|
| Rat | CACNB2-733R | Recombinant Rat CACNB2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
|
|
| Rat | CACNB2-733R-B | Recombinant Rat CACNB2 Protein Pre-coupled Magnetic Beads | HEK293 |
|
||
| Rhesus Macaque | CACNB2-601R | Recombinant Rhesus monkey CACNB2 Protein, His-tagged | Mammalian Cell | His |
|
|
| Rhesus Macaque | CACNB2-429R | Recombinant Rhesus Macaque CACNB2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
|
|
| Rhesus Macaque | CACNB2-429R-B | Recombinant Rhesus Macaque CACNB2 Protein Pre-coupled Magnetic Beads | HEK293 |
|
- Involved Pathway
- Protein Function
- Interacting Protein
CACNB2 involved in several pathways and played different roles in them. We selected most pathways CACNB2 participated on our site, such as MAPK signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with CACNB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | C11orf52;FAS;GNG12;FLNA;RAP1AA;PPP3CCB;MAPK13;FGF1A;MAPK10 |
| Cardiac muscle contraction | UQCRB;COX7A2L;MYL2;COX4I1;MYL3;UQCRC2;CACNG2A;COX7B;CACNA2D1 |
| Adrenergic signaling in cardiomyocytes | ATP1B3;PLCB3;MAPK14A;SCN1B;PPP2R5EB;PIK3R3A;ATP1B2A;ADRa1A;CALM2A |
| Oxytocin signaling pathway | ITPR1;RHOA;GNAS;ELK1;MAP2K5;GNAQ;PPP1R12B;GNAI1;PIK3R5 |
| Hypertrophic cardiomyopathy (HCM) | IL6;SGCA;SGCB;ITGB8;ITGA7;ACTB;Itga10&Itgb1;CACNA2D4;ITGA6 |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | ITGA10;ITGB6;DAG1;DSC2;TCF7;ACTN1;CACNG2;ACTG1;GJA1 |
| Dilated cardiomyopathy | CACNA2D4;TGFB3;MYH7;ACTG1;PRKACG;MYBPC3;ITGAV;TNNI3;SGCG |
CACNB2 has several biochemical functions, for example, calcium channel activity, calcium channel regulator activity, contributes_to high voltage-gated calcium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CACNB2 itself. We selected most functions CACNB2 had, and list some proteins which have the same functions with CACNB2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium channel activity | GRIN2B;CACNA1BA;CACNA1SB;CHRNA9;GPM6A;RYR1;PSEN1;TRPC1;SLC24A1 |
| calcium channel regulator activity | CACNA2D1;TSPAN13B;SGK3;GRM2A;SGK1;STIM1B;CACNA2D2;CACNB2;TMEM110 |
| contributes_to high voltage-gated calcium channel activity | CACNB4;CACNB2 |
| phosphoprotein binding | SRC;APTX;ARR3;LYN;RB1;SERPINB1A;PITX2;CACNB2;SFN |
| protein binding | RTN4R;MRPL4;RNF182;CCDC11;TAF15;UNC13D;KIAA1143;GSTO1;GOLPH3 |
| protein domain specific binding | ARR3;PPP3R1;SKIL;HIST1H4E;NEDD4;SNCA;HIST1H4I;YWHAZ;NCK1 |
| protein kinase binding | PTK2;PKD1;GRB7;SLC12A4;RELA;CD226;SUFU;TRIB3;FAM83A |
| voltage-gated calcium channel activity | CACNA1SA;CACNA2D4;TPCN2;CACNG7A;OPRM1;TPC3;CACNB2B;CACNA2D1;CACNB3A |
CACNB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CACNB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CACNB2.
q8ckn6_yerpe
- Q&As
- Reviews
Q&As (7)
Ask a questionBy associating with the main channel protein, CACNB2 can influence the channel's gating properties, open probability, and current amplitude.
Post-translational modifications such as phosphorylation have been reported on CACNB2, which can modulate its function.
CACNB2 mutations or dysregulation have been implicated in conditions like Brugada syndrome and certain psychiatric disorders.
CACNB2 primarily interacts with the alpha-1 subunit of calcium channels and might also interact with other regulatory or scaffolding proteins in specific cellular contexts.
Mutations in the CACNB2 gene can alter channel properties, potentially leading to diseases such as cardiac arrhythmias or neurological disorders.
CACNB2 is widely expressed, with notable concentrations in the brain and heart.
CACNB2 functions as an auxiliary subunit, modulating the activity, trafficking, and surface expression of voltage-gated calcium channels.
Customer Reviews (3)
Write a reviewInvaluable for our protein-related discoveries.
Outstanding purification techniques, yields high-quality samples.
Expertise in protein analysis, advances our research.
Ask a Question for All CACNB2 Products
Required fields are marked with *
My Review for All CACNB2 Products
Required fields are marked with *
