CACNB3
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Official Full Name
calcium channel, voltage-dependent, beta 3 subunit
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Overview
This gene encodes a regulatory beta subunit of the voltage-dependent calcium channel. Beta subunits are composed of;five domains, which contribute to the regulation of surface expression and gating of calcium channels and may also;play a role in the regulation of transcription factors and calcium transport. -
Synonyms
CACNB3; calcium channel, voltage-dependent, beta 3 subunit; voltage-dependent L-type calcium channel subunit beta-3; CAB3; CACB3_HUMAN; CACNLB3; Calcium Channel Voltage Dependent Beta 3 Subunit; Calcium channel voltage-dependent subunit beta 3; Calcium channel subunit beta 3; CACH3B;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- HEK293
- HEK293T
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- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- MYC
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- CACNB3 Related Articles
CACNB3 involved in several pathways and played different roles in them. We selected most pathways CACNB3 participated on our site, such as MAPK signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with CACNB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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MAPK signaling pathway | PDGFRB;FGFR2;GNA12;GADD45B;CACNA1B;CACNA2D2;Fgf15;TGFB2;MAPKAPK5 |
Cardiac muscle contraction | TNNI3;TNNT2;ACTC1B;ACTC1;CACNB3A;ATP1A4;COX6B1;ATP1B2;UQCR11 |
Adrenergic signaling in cardiomyocytes | BCL2A;SLC14A2;ADRB2A;ATP2B2;ATP1A1;GNAIA;ADCY7;PPP2R3C;ADCY8 |
Oxytocin signaling pathway | SRC;CALML3;PPP3CC;PLCB2;GNAI3;PPP1R12B;OXT;GNAS;PRKAG3 |
Hypertrophic cardiomyopathy (HCM) | IGF1;CACNB1;SGCG;MYL2;CACNG7;TNNI3;ITGA9;ITGAV;CACNG3 |
Arrhythmogenic right ventricular cardiomyopathy (ARVC) | SGCA;GJA1;ACTB;ITGA7;PKP2;CTNNA3;TCF7L2;ITGB5;CTNNA2 |
Dilated cardiomyopathy | ACTB;PLN;DMD;ITGAV;CACNG3;SGCA;MYBPC3;SGCB;CACNG1 |
CACNB3 has several biochemical functions, for example, high voltage-gated calcium channel activity, protein kinase binding, contributes_to voltage-gated calcium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CACNB3 itself. We selected most functions CACNB3 had, and list some proteins which have the same functions with CACNB3. You can find most of the proteins on our site.
Function | Related Protein |
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high voltage-gated calcium channel activity | CACNA1C;CACNB4B;CACNA1DA;CACNB2A;CACNB3A;CACNA1B;CACNB4A;CACNA1SB;CACNB2B |
protein kinase binding | LSM2;IL12RB2;DCX;TRIM22;TUBB3;BCL10;NEK9;GHR;MSN |
contributes_to voltage-gated calcium channel activity | CACNB4;CACNB3;CACNA2D1 |
CACNB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CACNB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CACNB3.
FASLG; SYT1
- Q&As
- Reviews
Q&As (7)
Ask a questionCACNB3 is expressed in various tissues, with notable concentrations in certain regions of the brain and other excitable cells.
Post-translational modifications such as phosphorylation may be present on CACNB3, affecting its function or interactions.
Dysfunctions or mutations in CACNB3 may be implicated in certain neurological or muscular disorders, although detailed research is necessary for concrete associations.
Specific mutations in the CACNB3 gene could alter its regulatory properties, affecting calcium channel dynamics and related physiological functions.
CACNB3 can impact the channel's gating properties, influencing calcium ion flow into cells upon depolarization.
CACNB3 primarily interacts with the alpha-1 subunit of calcium channels, and may also associate with other regulatory proteins.
CACNB3 functions as an auxiliary subunit, influencing the activity, trafficking, and surface expression of voltage-gated calcium channels.
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