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CACNB3

  • Official Full Name

    calcium channel, voltage-dependent, beta 3 subunit

  • Overview

    This gene encodes a regulatory beta subunit of the voltage-dependent calcium channel. Beta subunits are composed of;five domains, which contribute to the regulation of surface expression and gating of calcium channels and may also;play a role in the regulation of transcription factors and calcium transport.
  • Synonyms

    CACNB3; calcium channel, voltage-dependent, beta 3 subunit; voltage-dependent L-type calcium channel subunit beta-3; CAB3; CACB3_HUMAN; CACNLB3; Calcium Channel Voltage Dependent Beta 3 Subunit; Calcium channel voltage-dependent subunit beta 3; Calcium channel subunit beta 3; CACH3B;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • MYC
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CACNB3-520H Recombinant Human CACNB3 Mammalian Cell His
Human CACNB3-0273H Recombinant Human CACNB3 Protein, GST-Tagged Wheat Germ GST
Human CACNB3-268HCL Recombinant Human CACNB3 cell lysate N/A
Human CACNB3-2989HF Recombinant Full Length Human CACNB3 Protein, GST-tagged In Vitro Cell Free System GST 484 amino acids
Human CACNB3-1450HFL Recombinant Full Length Human CACNB3 Protein, C-Flag-tagged Mammalian cells Flag
Human CACNB3-483H-B Recombinant Human CACNB3 Protein Pre-coupled Magnetic Beads HEK293
Human CACNB3-2261H Recombinant Human CACNB3 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CACNB3-483H Recombinant Human CACNB3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Cacnb3-737M Recombinant Mouse Cacnb3 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat CACNB3-1070R Recombinant Rat CACNB3 Protein Mammalian Cell His
Rat CACNB3-734R-B Recombinant Rat CACNB3 Protein Pre-coupled Magnetic Beads HEK293
Rat CACNB3-734R Recombinant Rat CACNB3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CACNB3-602R Recombinant Rhesus monkey CACNB3 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CACNB3-430R Recombinant Rhesus Macaque CACNB3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CACNB3-430R-B Recombinant Rhesus Macaque CACNB3 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CACNB3 Related Articles

CACNB3 involved in several pathways and played different roles in them. We selected most pathways CACNB3 participated on our site, such as MAPK signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with CACNB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayPDGFRB;FGFR2;GNA12;GADD45B;CACNA1B;CACNA2D2;Fgf15;TGFB2;MAPKAPK5
Cardiac muscle contractionTNNI3;TNNT2;ACTC1B;ACTC1;CACNB3A;ATP1A4;COX6B1;ATP1B2;UQCR11
Adrenergic signaling in cardiomyocytesBCL2A;SLC14A2;ADRB2A;ATP2B2;ATP1A1;GNAIA;ADCY7;PPP2R3C;ADCY8
Oxytocin signaling pathwaySRC;CALML3;PPP3CC;PLCB2;GNAI3;PPP1R12B;OXT;GNAS;PRKAG3
Hypertrophic cardiomyopathy (HCM)IGF1;CACNB1;SGCG;MYL2;CACNG7;TNNI3;ITGA9;ITGAV;CACNG3
Arrhythmogenic right ventricular cardiomyopathy (ARVC)SGCA;GJA1;ACTB;ITGA7;PKP2;CTNNA3;TCF7L2;ITGB5;CTNNA2
Dilated cardiomyopathyACTB;PLN;DMD;ITGAV;CACNG3;SGCA;MYBPC3;SGCB;CACNG1

CACNB3 has several biochemical functions, for example, high voltage-gated calcium channel activity, protein kinase binding, contributes_to voltage-gated calcium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CACNB3 itself. We selected most functions CACNB3 had, and list some proteins which have the same functions with CACNB3. You can find most of the proteins on our site.

Function Related Protein
high voltage-gated calcium channel activityCACNA1C;CACNB4B;CACNA1DA;CACNB2A;CACNB3A;CACNA1B;CACNB4A;CACNA1SB;CACNB2B
protein kinase bindingLSM2;IL12RB2;DCX;TRIM22;TUBB3;BCL10;NEK9;GHR;MSN
contributes_to voltage-gated calcium channel activityCACNB4;CACNB3;CACNA2D1

CACNB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CACNB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CACNB3.

FASLG; SYT1

Murakami, M; Nakagawasai, O; et al. Modified behavioral characteristics following ablation of the voltage-dependent calcium channel beta 3 subunit. BRAIN RESEARCH 1160:102-112(2007).
Endoh, T; et al. Characterization of modulatory effects of postsynaptic metabotropic glutamate receptors on calcium currents in rat nucleus tractus solitarius. BRAIN RESEARCH 1024:212-224(2004).
  • Q&As
  • Reviews

Q&As (7)

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In which human tissues or organs is CACNB3 most prominently expressed? 02/05/2022

CACNB3 is expressed in various tissues, with notable concentrations in certain regions of the brain and other excitable cells.

Which post-translational modifications have been detected on CACNB3? 12/27/2021

Post-translational modifications such as phosphorylation may be present on CACNB3, affecting its function or interactions.

What diseases or conditions are associated with alterations in CACNB3 function or expression? 10/06/2021

Dysfunctions or mutations in CACNB3 may be implicated in certain neurological or muscular disorders, although detailed research is necessary for concrete associations.

Are there any genetic mutations in the CACNB3 gene known to affect its regulatory activity? 02/23/2021

Specific mutations in the CACNB3 gene could alter its regulatory properties, affecting calcium channel dynamics and related physiological functions.

How does CACNB3 modulate the activity of voltage-gated calcium channels? 09/05/2018

CACNB3 can impact the channel's gating properties, influencing calcium ion flow into cells upon depolarization.

Are there specific proteins known to directly interact with CACNB3? 03/14/2018

CACNB3 primarily interacts with the alpha-1 subunit of calcium channels, and may also associate with other regulatory proteins.

What is the main biological role of CACNB3 in the context of voltage-gated calcium channels? 10/30/2017

CACNB3 functions as an auxiliary subunit, influencing the activity, trafficking, and surface expression of voltage-gated calcium channels.

Customer Reviews (3)

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Reviews
03/29/2022

    Critical support for our protein experiments.

    09/16/2021

      Valuable asset for our protein research progress.

      09/03/2020

        Efficient purification services, a research time-saver.

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