CACNG1
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Official Full Name
calcium channel, voltage-dependent, gamma subunit 1
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Overview
Voltage-dependent calcium channels are composed of five subunits. The protein encoded by this gene represents one of these subunits, gamma, and is one of two known gamma subunit proteins. This particular gamma subunit is part of skeletal muscle 1,4-dihydropyridine-sensitive calcium channels and is an integral membrane protein that plays a role in excitation-contraction coupling. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members that function as transmembrane AMPA receptor regulatory proteins (TARPs). -
Synonyms
CACNG1; calcium channel, voltage-dependent, gamma subunit 1; CACNLG; voltage-dependent calcium channel gamma-1 subunit; Dihydropyridine sensitive L type skeletal muscle calcium channel gamma subunit; skeletal muscle calcium channel subunit gamma; CACNLG calcium channel neuronal dihydrpyridine sensitive gamma subunit; Calcium channel L type gamma polypeptide; Calcium channel voltage dependent gamma subunit 1; CCG1_HUMAN; Dihydropyridine sensitive L type skeletal muscle calcium channel subunit gamma; Dihydropyridine-sensitive L-type; fb43f02; fi19g08; L type calcium channel gamma polypeptide; MGC117703; Voltage dependent calcium channel gamma 1 subunit 2; wu:fb43f02; zgc:55364; L-type calcium channel gamma polypeptide; neuronal dihydropyridine-sensitive calcium channel gamma subunit; dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma;
- Cell & Tissue Lysates
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Bos taurus (Bovine)
- Chicken
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Oryctolagus cuniculus (Rabbit)
- Rat
- Rattus norvegicus (Rat)
- Sus scrofa (Pig)
- E.coli expression system
- HEK293
- In vitro E. coli expression system
- Mammalian Cell
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- CACNG1 Related Articles
CACNG1 involved in several pathways and played different roles in them. We selected most pathways CACNG1 participated on our site, such as MAPK signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with CACNG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | CACNB4;PTPN7;MAPK10;GADD45AB;FGFR2;FGF6A;PRKACBA;PAK2B;TAOK3 |
| Cardiac muscle contraction | CACNG6A;TPMA;ACTC1A;ATP1A3A;UQCR10;UQCRC2A;COX4I2;CACNG2;ATP1B2B |
| Adrenergic signaling in cardiomyocytes | AGTR2;CALM3B;ADRB2B;PIK3R1;MAPK14B;ATP1B2B;ATF4B1;PRKACBA;PRKACAA |
| Oxytocin signaling pathway | CAMK2G;NFATC3;PPP3R1;CACNA2D4;PLA2G4C;MYLK2;NFATC1;CAMK4;CACNB4 |
| Hypertrophic cardiomyopathy (HCM) | ITGA2;PRKAA2;DES;ITGB8;PRKAA1;ACTB;CACNG8;SGCA;ITGB7 |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | SGCB;TCF7L2;SGCA;ACTB;ITGB7;ITGB5;CACNG2;EMD;DSC2 |
| Dilated cardiomyopathy | ITGB7;ACTG1;CACNB3;CACNA2D2;ADRB1;TGFB1;Adcy4;SGCG;MYBPC3 |
CACNG1 has several biochemical functions, for example, protein binding, voltage-gated calcium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CACNG1 itself. We selected most functions CACNG1 had, and list some proteins which have the same functions with CACNG1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | EIF3A;CYC1;RCOR2;RAPGEF3;POU3F2;ZNF398;AP2M1;DDB2;GTF2A1L |
| voltage-gated calcium channel activity | CACNG1A;ATP6V0CB;GRM7;CACNG3;CACNG4;CACNG8A;CACNB3A;CACNA1DA;CACNB1 |
CACNG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CACNG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CACNG1.
a8ka83_human
- Q&As
- Reviews
Q&As (7)
Ask a questionDysregulation or mutations in CACNG1 have been implicated in some neurological disorders, although more research is needed for concrete associations.
Genetic mutations in the CACNG1 gene can alter its regulatory activity, potentially affecting the dynamics of associated calcium channels.
Specific post-translational modifications like phosphorylation might be present on CACNG1, affecting its function or protein-protein interactions.
CACNG1 interacts mainly with the alpha-1 subunit of calcium channels and may also have interactions with other auxiliary subunits or proteins.
CACNG1 can influence the channel's gating dynamics and open probability, thus modulating calcium entry into cells.
CACNG1 is widely expressed, but it is particularly found in the brain and nervous system.
CACNG1 acts as an auxiliary subunit, helping in the modulation of the activity and surface expression of voltage-gated calcium channels.
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