CAPN6
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Official Full Name
CAPN6 calpain 6 [ Homo sapiens ]
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Overview
The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimers disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimers disease. -
Synonyms
CALP M; Calpain-6; Calpain-like protease X-linked; Calpamodulin; CALPM; CAN6_HUMAN; CANP X; CANPX; CAPN 6; CAPN6;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- MYC
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
CAPN6 involved in several pathways and played different roles in them. We selected most pathways CAPN6 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CAPN6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
CAPN6 has several biochemical functions, for example, molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by CAPN6 itself. We selected most functions CAPN6 had, and list some proteins which have the same functions with CAPN6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| molecular_function | TMEM194B;HAUS8;RPRMB;CYSTM1;LEPRE1;KRTAP6-5;TMEM91;PHYHIPLA;FAM43B |
CAPN6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CAPN6 here. Most of them are supplied by our site. Hope this information will be useful for your research of CAPN6.
SLC9A3R1; EZR; A2M
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