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CAPNS1

  • Official Full Name

    calpain, small subunit 1

  • Overview

    Calpains are a ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. Calpain families have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. Calpain I and II are heterodimeric with distinct large subunits associated with common small subunits, all of which are encoded by different genes. This gene encodes a small subunit common to both calpain I and II and is associated with myotonic dystrophy. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms

    CAPNS1; calpain, small subunit 1; 30K; CANP; CDPS; CSS1; CANPS; CAPN4; CALPAIN4; calpain small subunit 1; CANP small subunit; calpain regulatory subunit; calpain, small polypeptide; calpain 4, small subunit (30K); calcium-dependent protease, small subunit; calcium-dependent protease small subunit 1; calcium-activated neutral proteinase small subunit;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • C
  • Myc
  • DDK
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • SUMO
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CAPNS1-0373H Recombinant Human CAPNS1 Protein, GST-Tagged Wheat Germ GST
Human CAPNS1-1426H Recombinant Human CAPNS1 protein, His & GST-tagged E.coli His/GST Met1~Ser268 (Accession # P04632)
Human CAPNS1-188H Recombinant Human CAPNS1, His-tagged E.coli His 84-268aa
Human CAPNS1-279HCL Recombinant Human CAPNS1 cell lysate N/A
Human CAPNS1-2827HF Recombinant Full Length Human CAPNS1 Protein, GST-tagged In Vitro Cell Free System GST 268 amino acids
Human CAPNS1-2487H Recombinant Human CAPNS1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CAPNS1-384H Recombinant Human CAPNS1 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human CAPNS1-0835H Recombinant Human CAPNS1 Protein (Met1-Ser268), N-GST tagged E.coli N-GST Met1-Ser268
Human CAPNS1-723H Recombinant Human CAPNS1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CAPNS1-2631H Recombinant Human CAPNS1 protein, His-SUMO-tagged E.coli His-SUMO 1-268aa
Mouse CAPNS1-2701M Recombinant Mouse CAPNS1 Protein Mammalian Cell His
Mouse CAPNS1-1222M Recombinant Mouse CAPNS1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CAPNS1-1222M-B Recombinant Mouse CAPNS1 Protein Pre-coupled Magnetic Beads HEK293
Rat CAPNS1-1126R Recombinant Rat CAPNS1 Protein Mammalian Cell His
Rat CAPNS1-790R-B Recombinant Rat CAPNS1 Protein Pre-coupled Magnetic Beads HEK293
Rat CAPNS1-790R Recombinant Rat CAPNS1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CAPNS1 Related Articles

CAPNS1 involved in several pathways and played different roles in them. We selected most pathways CAPNS1 participated on our site, such as Apoptosis Modulation and Signaling, Degradation of the extracellular matrix, Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with CAPNS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Apoptosis Modulation and SignalingBOK;HN1;HRK;BAG3;BIK;BCL2L10;CDKN2A;PTPN13;BCL2L11
Degradation of the extracellular matrixMMP19;COL23A1;ADAM15;MMP10;BMP1;COL9A1;COL15A1B;MMP8;MMP17
Extracellular matrix organizationCEACAM1;BMP1A;COL4A6;CTSD;MMP20;CTSG;JAM2B;CMA1;PCOLCEA
Integrin-mediated cell adhesionCAPNS1;SEPP1;CAPN3;CAPN10;SEPP1A;CAPN3A;CAPN9;MAPK4;MYLK2

CAPNS1 has several biochemical functions, for example, calcium ion binding, calcium-dependent cysteine-type endopeptidase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CAPNS1 itself. We selected most functions CAPNS1 had, and list some proteins which have the same functions with CAPNS1. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingDSG1;EFHD1;EGFL6;NOX5;LALBA;RASGRP2;PRRG4;MYLPFA;S100A14
calcium-dependent cysteine-type endopeptidase activityCAPN1A;CAPN2B;CAPN2L;CAPN2A;CAPN1;CAPN3;CAPN5;CAPN1B;GCA
protein bindingADAT2;RNF220;DNMT3L;LRRK1;ADAM1B;LAGE3;KCNJ15;WFIKKN1;NKX3-1

CAPNS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CAPNS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CAPNS1.

CAPN1; CAPN2; AGTRAP; RASA1; TRAF5; CDK4; ARR3; STAT3; TERF1; ATP5J2; RAB1A

Hsu, CY; Henry, J; et al. Deimination of Human Filaggrin-2 Promotes Its Proteolysis by Calpain 1. JOURNAL OF BIOLOGICAL CHEMISTRY 286:23222-23233(2011).
Shaikh, S; Samanta, K; et al. m-Calpain-mediated cleavage of Na+/Ca2+ exchanger-1 in caveolae vesicles isolated from pulmonary artery smooth muscle. MOLECULAR AND CELLULAR BIOCHEMISTRY 341:167-180(2010).
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