CASP6
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Official Full Name
caspase 6, apoptosis-related cysteine peptidase
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Overview
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in two transcript variants that encode different isoforms. [provided by RefSeq, Jul 2008] -
Synonyms
CASP6; caspase 6, apoptosis-related cysteine peptidase; MCH2; caspase-6; apoptotic protease MCH-2; caspase 6, apoptosis-related cysteine protease;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bovine
- Chicken
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- CASP6 Related Research Area
CASP6 involved in several pathways and played different roles in them. We selected most pathways CASP6 participated on our site, such as Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CASP6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Apoptosis | CDK5RAP2;TRAF2;IRF1B;BOKA;HIST1H1B;Casp3;PRKAR2A;BCL2L1;DFFA |
CASP6 has several biochemical functions, for example, cysteine-type endopeptidase activity, cysteine-type endopeptidase activity involved in execution phase of apoptosis, cysteine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CASP6 itself. We selected most functions CASP6 had, and list some proteins which have the same functions with CASP6. You can find most of the proteins on our site.
Function | Related Protein |
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cysteine-type endopeptidase activity | USP3;MALT1;USP45;USP1;USP10;USP24;CASP8L1;CTSW;FMNL3 |
cysteine-type endopeptidase activity involved in execution phase of apoptosis | CASP6L1;CASP3A;Casp3;CASP6;CASP3B;CASP6L2;CASP7 |
cysteine-type peptidase activity | FAM105B;SENP3B;CTSW;Ctsl;ATG4A;USP9;CTSL1B;CTSM;CAPN1B |
identical protein binding | TNF;SNX1;BIN1;MSANTD3;DRD2;CDC42;SHARPIN;BLOC1S6;PRDX1 |
protein binding | CXXC1;KRTAP5-9;INCA1;LBH;MAGEA3;ANKHD1;MANBAL;NGB;KRTAP10-9 |
CASP6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CASP6 here. Most of them are supplied by our site. Hope this information will be useful for your research of CASP6.
act-veid; NUCB2; NUCB1; PARP10; ATG16L1; APP; CASP3; SATB1; PRKAB2; CHD3; PIN1; TAB1; MAPK6; IKBKG
- Q&As
- Reviews
Q&As (5)
Ask a questionTargeting CASP6 activity may offer a potential therapeutic strategy for slowing down the progression of Alzheimer's disease.
There is potential for CASP6 to be targeted in other diseases involving aberrant cell death pathways, such as certain types of cancer and autoimmune diseases.
Several research groups are working on developing small molecule inhibitors and other drugs that specifically target CASP6 for therapeutic purposes.
As with any targeted therapy, potential side effects and off-target effects of CASP6 inhibition or modulation need to be carefully evaluated in clinical trials.
CASP6 is also being investigated in the context of other neurodegenerative disorders such as Parkinson's disease and amyotrophic lateral sclerosis (ALS).
Customer Reviews (3)
Write a reviewIts remarkable performance in ELISA, protein electron microscopy structure analysis, and Western Blotting sets it apart as a top recommendation.
The CASP6 protein has proven invaluable in protein electron microscopy structure analysis, allowing for detailed investigations and providing critical insights.
Whether it's protein quantification, structural analysis, or Western Blotting, the CASP6 protein has consistently delivered exceptional results, earning my highest recommendation.
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