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CASP7

  • Official Full Name

    caspase 7, apoptosis-related cysteine peptidase

  • Overview

    This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of this caspase is cleaved by caspase 3 and 10. It is activated upon cell death stimuli and induces apoptosis. Alternative splicing results in four transcript variants, encoding three distinct isoforms.
  • Synonyms

    CASP7; Apoptotic protease Mch3; CASP 7; Caspase 7 subunit p11; Caspase 7 subunit p20; CMH1; ICE LAP3; ICE like apoptotic protease 3; OTTHUMP00000020510; OTTHUMP00000020511; OTTHUMP00000020512; OTTHUMP00000020513; OTTHUMP00000020514; Lice2 alpha/beta/gamma; caspase 7 isoform delta; caspase 7, apoptosis-related cysteine protease; caspase 7, apoptosis-related cysteine peptidase; MCH3; CMH-1; ICE-LAP3; EC 3.4.22.60; EC 3.4.22;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CASP7-602H Recombinant Human Caspase 7, Apoptosis-related Cysteine Peptidase E.coli N/A
Human CASP7-681H Recombinant Human CASP7 Protein, His-tagged E.coli His Ala24~Asp198
Human CASP7-0430H Recombinant Human CASP7 Protein, GST-Tagged Wheat Germ GST
Human CASP7-7269H Recombinant Human CASP7 protein(Met1-Gln303), His-tagged E. coli C-His Met1-Gln303
Human CASP7-680H Recombinant Human CASP7 Protein, His-tagged E.coli His Ala207~Gln303
Human CASP7-0429H Active Recombinant Human CASP7 Protein E.coli N/A
Human CASP7-7832HCL Recombinant Human CASP7 293 Cell Lysate HEK293 N/A
Human CASP7-7833HCL Recombinant Human CASP7 293 Cell Lysate HEK293 N/A
Human CASP7-3432H Recombinant Human CASP7 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CASP7-1605H Recombinant Human CASP7 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CASP7-6396H Recombinant Human CASP7 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CASP7-2738HF Recombinant Full Length Human CASP7 Protein, GST-tagged In Vitro Cell Free System GST 336 amino acids
Human CASP7-301351H Recombinant Human CASP7 protein, GST-tagged E.coli GST Met1-Cys100
Human CASP7-2063HFL Recombinant Full Length Human CASP7 Protein, C-Flag-tagged Mammalian cells Flag
Human CASP7-508H Recombinant Human CASP7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CASP7-508H-B Recombinant Human CASP7 Protein Pre-coupled Magnetic Beads HEK293
Human CASP7-0862H Recombinant Human CASP7 Protein (Ala24-Asp198), His tagged E.coli His Ala24-Asp198
Mouse CASP7-2755M Recombinant Mouse CASP7 Protein Mammalian Cell His
Mouse Casp7-682M Recombinant Mouse Casp7 Protein, GST-tagged E.coli GST Ala24~Asp198
Mouse Casp7-683M Recombinant Mouse Casp7 Protein, His-tagged E.coli His Ala207~Arg303
Mouse Casp7-772M Recombinant Mouse Casp7 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse CASP7-1246M-B Recombinant Mouse CASP7 Protein Pre-coupled Magnetic Beads HEK293
Mouse CASP7-1246M Recombinant Mouse CASP7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Casp7-684R Recombinant Rat Casp7 Protein, His-tagged E.coli His Met1~Asn250
Zebrafish CASP7-2786Z Recombinant Zebrafish CASP7 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CASP7 Related Research Area

CASP7 involved in several pathways and played different roles in them. We selected most pathways CASP7 participated on our site, such as Apoptosis, TNF signaling pathway, Non-alcoholic fatty liver disease (NAFLD), which may be useful for your reference. Also, other proteins which involved in the same pathway with CASP7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ApoptosisCYCS;FADD;YWHAQ;CASP8L1;PIK3R3A;RELA;PPP3CA;STK24B;DYNLL2
TNF signaling pathwayPTGS2;MAPK11;TAB2;IL15;RELA;RPS6KA5;PIK3CG;MAPK10;CXCL10
Non-alcoholic fatty liver disease (NAFLD)NDUFA13;ERN1;COX6B2;PRKAB1;NDUFA9;UQCRQ;NDUFB8;TRAF2;UQCRB
Alzheimers diseaseATP2A3;NDUFV2;NOS1;ATP5F1;NDUFA3;NDUFS3;ATP5B;NAE1;LRP1
PertussisIL6;RELA;ITGB2;LY96;IRF3;C1S;CALM4;C1QB;IL-8
LegionellosisCYCS;HSF1;NAIP6;SAR1A;NFKB1;CLK1;IL12A;CXCL3;IL1B

CASP7 has several biochemical functions, for example, cysteine-type endopeptidase activity, cysteine-type endopeptidase activity involved in execution phase of apoptosis, cysteine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CASP7 itself. We selected most functions CASP7 had, and list some proteins which have the same functions with CASP7. You can find most of the proteins on our site.

Function Related Protein
cysteine-type endopeptidase activityUSP14;USP6;PDIA3;CASP8L1;CASP3B;CASPA;CTSJ;USP28;USP19
cysteine-type endopeptidase activity involved in execution phase of apoptosisCASP6;CASP6L2;CASP6L1;CASP7;CASP3B;Casp3;CASP3A
cysteine-type peptidase activityUFSP2;FAM105B;USP27X;OTUD5A;CTSBA;CAPN2L;CAPN3A;SENP3B;GM12824
protein bindingMMP15;EPN1;CD37;CCNY;CD72;AP2A2;CAPNS2;MUM1;RPS3A

CASP7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CASP7 here. Most of them are supplied by our site. Hope this information will be useful for your research of CASP7.

XIAP; PAK2; SAT; SMPD1; BIRC2

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